Natural, synthetic and commercially-available biopolymers used to regenerate tendons and ligaments

Heidari, Behzad Shiroud; Ruan, Rui; Vahabli, Ebrahim; Chen, Peilin; De‐Juan‐Pardo, Elena M.; Zheng, Minghao; Doyle, Barry

doi:10.1016/j.bioactmat.2022.04.003

Cited by 40 publications

(36 citation statements)

References 229 publications

(269 reference statements)

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“…Synthetic biopolymers and synthetic-based biocomposites are the most widely studied materials in TL and interface tissue engineering [ 1 ]. So far, we showed that the novel PDO/LCL/silk biocomposites offer improved tensile properties, degradation rate, in vitro and in vivo biocompatibility for TL tissue engineering applications.…”

Section: Resultsmentioning

confidence: 99%

“…So far, we showed that the novel PDO/LCL/silk biocomposites offer improved tensile properties, degradation rate, in vitro and in vivo biocompatibility for TL tissue engineering applications. The important advantages of synthetic biopolymers are large-scale manufacturing, ease of processability, good mechanical properties, and controlled absorption in the human body [ 1 , 9 ]. Fibre extrusion in combination with the braiding/knitting technique is a well-known approach to creating micro- and nanofibrillar scaffolds with different alignment levels for tendon tissue engineering [ 1 , 9 ].…”

Section: Resultsmentioning

confidence: 99%

“…Synthetic polymers are often chosen for such applications because of the level of control over mechanical properties, degradation rate, and easy reproducibility with large-scale production. Alternatively, natural biopolymers such as proteins are often favoured because of their high degree of scaffold-tissue compatibility due to the positive biological recognition of their chemical make-up [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Novel hybrid biocomposites for tendon grafts: The addition of silk to polydioxanone and poly(lactide-co-caprolactone) enhances material properties, in vitro and in vivo biocompatibility

Heidari

López

Harrington

et al. 2023

Bioactive Materials

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Novel hybrid biocomposites for tendon grafts: The addition of silk to polydioxanone and poly(lactide-co-caprolactone) enhances material properties, in vitro and in vivo biocompatibility

Heidari

López

Harrington

et al. 2023

Bioactive Materials

Self Cite

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“…In earlier years, it was common to use only one material to create scaffolds [ 79 ]. However, clinical use and further research have highlighted many problems with this method, including poor mechanical strength and fast degradation rate of natural polymer scaffolds [ 80 ].…”

Section: Products Of Tendon and Ligament Reconstruction And Repairmentioning

confidence: 99%

Functional biomaterials for tendon/ligament repair and regeneration

Tang

Wang

Xiang

et al. 2022

Regenerative Biomaterials

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With an increase in life expectancy and the popularity of high-intensity exercise, the frequency of tendon and ligament injuries has also increased. Owing to the specificity of its tissue, the rapid restoration of injured tendons and ligaments is challenging for treatment. This review summarises the latest progress in cells, biomaterials, active molecules, and construction technology in treating tendon/ligament injuries. The characteristics of supports made of different materials and the development and application of different manufacturing methods are discussed. The development of natural polymers, synthetic polymers, and composite materials has boosted the use of scaffolds. In addition, the development of electrospinning and hydrogel technology has diversified the production and treatment of materials. First, this paper briefly introduces the structure, function, and biological characteristics of tendons/ligaments. Then, it summarises the advantages and disadvantages of different materials, such as natural polymer scaffolds, synthetic polymer scaffolds, composite scaffolds, and ECM-derived biological scaffolds, in the application of tendon/ligament regeneration. We then discuss the latest applications of electrospun fiber scaffolds and hydrogels in regeneration engineering. Finally, we discuss the current problems and future directions in the development of biomaterials for restoring damaged tendons and ligaments.

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“…( Chartrain et al, 2022 ). It is commonly used in intra-articular injections to stimulate and repair damaged cartilage because it promotes cell adhesion and proliferation and presents anti-inflammatory properties as well as non-immunogenicity ( Shiroud Heidari et al, 2023 ). However, hydrogels made of HA present quick degradation rates, for this reason it is necessary to modify them to enhance their degradation properties.…”

Section: Introductionmentioning

confidence: 99%

Chemically crosslinked hyaluronic acid-chitosan hydrogel for application on cartilage regeneration

Escalante

Rico²,

Becerra³

et al. 2022

Front. Bioeng. Biotechnol.

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Articular cartilage is an avascular tissue that lines the ends of bones in diarthrodial joints, serves as support, acts as a shock absorber, and facilitates joint’s motion. It is formed by chondrocytes immersed in a dense extracellular matrix (principally composed of aggrecan linked to hyaluronic acid long chains). Damage to this tissue is usually associated with traumatic injuries or age-associated processes that often lead to discomfort, pain and disability in our aging society. Currently, there are few surgical alternatives to treat cartilage damage: the most commonly used is the microfracture procedure, but others include limited grafting or alternative chondrocyte implantation techniques, however, none of them completely restore a fully functional cartilage. Here we present the development of hydrogels based on hyaluronic acid and chitosan loaded with chondroitin sulfate by a new strategy of synthesis using biodegradable di-isocyanates to obtain an interpenetrated network of chitosan and hyaluronic acid for cartilage repair. These scaffolds act as delivery systems for the chondroitin sulfate and present mucoadhesive properties, which stabilizes the clot of microfracture procedures and promotes superficial chondrocyte differentiation favoring a true articular cellular colonization of the cartilage. This double feature potentially improves the microfracture technique and it will allow the development of next-generation therapies against articular cartilage damage.

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Natural, synthetic and commercially-available biopolymers used to regenerate tendons and ligaments

Cited by 40 publications

References 229 publications

Novel hybrid biocomposites for tendon grafts: The addition of silk to polydioxanone and poly(lactide-co-caprolactone) enhances material properties, in vitro and in vivo biocompatibility

Novel hybrid biocomposites for tendon grafts: The addition of silk to polydioxanone and poly(lactide-co-caprolactone) enhances material properties, in vitro and in vivo biocompatibility

Functional biomaterials for tendon/ligament repair and regeneration

Chemically crosslinked hyaluronic acid-chitosan hydrogel for application on cartilage regeneration

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