Crevicular fluid levels of plasma glutathione peroxidase (eGPx) in periodontal health and disease

Patel, Swati; Pradeep, A.R.; Chowdhry, Shikha

doi:10.1016/j.archoralbio.2009.02.002

Cited by 34 publications

(37 citation statements)

References 23 publications

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“…The findings in our previous research were consistent with the results of Wei et al and it was found that in periodontitis patients, both total amount and concentration of eGPx were higher in GCF as compared to the levels in healthy patients [14,16], and the levels of eGPx from the gingivitis sites of periodontitis patients were less that the levels in periodontitis sites but were higher than those of healthy patients. However, Huang et al [17] found that within periodontitis subjects, glutathione peroxidase levels correlated negatively with pocket depth and attachment loss and increased posttherapy.…”

Section: Discussionsupporting

confidence: 82%

“…We found that eGPx concentration in GCF increases proportionally with the severity of periodontal disease. Further, the treatment aimed at arresting periodontal disease resulted in statistically significant reduction in the levels of GCF eGPx proportionally [14]. However till date no study has correlated the GCF and serum levels of eGPX in periodontal health and disease.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Nonsurgical Periodontal Therapy on Crevicular Fluid and Serum Glutathione Peroxidase Levels

2012

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Abstract.Background: Plasma glutathione peroxidase (eGPx) is an important selenium containing antioxidant in human defense against oxidative stress. While crevicular fluid (GCF) eGPx levels and its association with periodontal disease is well documented, there is no data on correlation of GCF and serum eGPx levels in chronic periodontitis. Hence this study was undertaken to further probe into the role of oxidative stress in periodontal diseases and effect of nonsurgical periodontal therapy (NSPT) by correlating GCF and serum levels of eGPx. Materials and methods: Thirty subjects (16-Males and 14-Females; age: 30-38 years) participated in the study. The subjects were divided, based on gingival index, probing pocket depth and clinical attachment level into: Healthy (group-1, n = 10), Gingivitis (group-2, n = 10) and Periodontitis (group-3, n = 10). Chronic periodontitis patients after NSPT constituted group 4. GCF and serum samples collected from each subject were quantified for eGPx levels using Enzyme linked Immunosorbent Assay. Results: The mean eGPx concentrations increased from health (14.01 ng/µl and 78.26 ng/ml) to gingivitis (22.86 ng/µl and 90.44 ng/ml) and then to periodontitis (29.89 ng/µl and 103.43 ng/ml), in GCF and serum respectively. After NSPT, there was statistically significant reduction in eGPx concentration in GCF and serum (19.41 ng/µl and 85.21 ng/ml). Further, all the GCF eGPx values showed a positive correlation to that of serum eGPx level. Conclusion: Thus, increased eGPx concentration in GCF can be considered as an indicator of local increase in oxidative stress. While, increase in serum eGPx levels indicates that periodontal disease can also lead to increased oxidative stress at the systemic level.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Effect of Nonsurgical Periodontal Therapy on Crevicular Fluid and Serum Glutathione Peroxidase Levels

2012

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“…By creating reactive oxygen species in the process of neutrophil activity, ionic balance is disrupted and periodontal tissue is damaged by production of free oxygen radicals such as OH and H 2 O 2 , leading to development of periodontal disease 12 , 32 . Factors capable of eliminating these free radicals or inhibiting their production can prevent the development or progression of periodontal disease 33–37 . Gemfibrozil belongs to a group of drugs known as “fibrates.” Fibrates enhance oxidation of fatty acids in the liver and muscles and decrease the rate of hepatic lipogenesis; 9 also, they increase production of apoA‐I and apoA‐II in the liver, which may contribute to an increase in plasma level of HDL 38 .…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Triglyceride Level and Gemfibrozil Consumption With Periodontal Status

Sayar

Akhondi

Fallah

et al. 2017

Journal of Periodontology

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“…[212223] Briefly, all clinical assessments using a periodontal probe (UNC-15, Hu-Freidy, Chicago, IL, USA), radiographs, group allocations and sampling-site selections were performed by one examiner (ARP) to ensure adequate intra-examiner reproducibility. Samples were collected on the subsequent day by a second examiner (SPP).…”

Section: Methodsmentioning

confidence: 99%

Resistin in serum and gingival crevicular fluid as a marker of periodontal inflammation and its correlation with single-nucleotide polymorphism in human resistin gene at −420

Patel

Raju

2013

Contemp Clin Dent

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Aims:Resistin is an adipocytokine, which have been studied for its role in insulin resistance and recently in inflammation. The aim of the present study is to assess the concentration of resistin in serum and gingival crevicular fluid (GCF) and to compare the levels between subjects with and without periodontitis and type 2 diabetes mellitus (T2DM) and to further correlate the resistin levels with the single-nucleotide polymorphism (SNP) at −420.Setting and Designs:A total of 96 subjects (48 males and 48 females) were divided on the basis of gingival index (GI), probing pocket depth (PD), clinical attachment level (CAL) and hemoglobin A1c levels into healthy (group 1, n = 24), uncontrolled-diabetes related periodontitis (group 2, n = 24), controlled-diabetes related periodontitis (group 3, n = 24) and chronic periodontitis without T2DM (group 4, n = 24).Materials and Methods:The GCF and serum levels of resistin were quantified using the enzyme-linked immunosorbent assay and compared among the study groups. Further, the association of the resistin levels with periodontal inflammation and SNP at −420 was studied.Results and Conclusion:The resistin levels in GCF and serum from patients with periodontitis or diabetes mellitus related periodontitis (controlled or uncontrolled) were higher than that of healthy subjects and correlated positively with GI. Further, subjects with GG genotype at −420 showed significantly higher GI, PD, CAL as compared with genotype group CC. Resistin was detected in all serum and GCF samples and was significantly higher in periodontitis. Further, GG genotype at −420 was associated significantly with periodontal inflammation and resistin levels.

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Crevicular fluid levels of plasma glutathione peroxidase (eGPx) in periodontal health and disease

Cited by 34 publications

References 23 publications

Effect of Nonsurgical Periodontal Therapy on Crevicular Fluid and Serum Glutathione Peroxidase Levels

Effect of Nonsurgical Periodontal Therapy on Crevicular Fluid and Serum Glutathione Peroxidase Levels

Association of Serum Triglyceride Level and Gemfibrozil Consumption With Periodontal Status

Resistin in serum and gingival crevicular fluid as a marker of periodontal inflammation and its correlation with single-nucleotide polymorphism in human resistin gene at −420

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