COVID‐19 in a case with Kikuchi‐Fujimoto disease

Jaseb, Kaveh; Fard, Najmeh Nameh Goshay; Rezaei, Nima; Sadeghian, Siavash; Sadeghian, Saeid

doi:10.1002/ccr3.3748

Cited by 16 publications

(11 citation statements)

References 7 publications

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“…KFD following vaccination has been very rarely reported following human papilloma virus and influenza vaccines [16] , [17] . Few case reports have linked KFD in association with SARS CoV2 infection [18] , [19] . Several cases of lymphadenopathy following COVID 19 vaccination.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto disease following SARS CoV2 vaccination: Case report

Soub

Ibrahim

Maslamani

et al. 2021

IDCases

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Kikuchi's disease (KD) also known as Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis was first described in 1972 independently by Kikuchi and Fujimoto et al. It is a benign self-limited condition of unknown etiology which usually presents with cervical lymphadenopathy or fever of unknown origin. The diagnosis of KFD is based on histopathologic examination of the involved lymph node, showing the presence of well-defined necrosis without granulocytic cells. There is no special treatment for KFD. However non-steroidal anti-inflammatory drugs or corticosteroids are required occasionally to control the associated systemic manifestations. The outcome of the disease is usually favorable with resolution of symptoms in most cases within one to four months. We report a case of Kikuchi-Fujimoto disease that occurred in a young Qatari male patient 10 days following receiving the first dose of BNT162b2 vaccine. Diagnosis was established by lymph node biopsy and recovery was complete after 10 days.

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Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto disease following SARS CoV2 vaccination: Case report

Soub

Ibrahim

Maslamani

et al. 2021

IDCases

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“…In addition, KFD can occur post or concurrent with COVID-19 infection [15,16]. While the ethnicity of the patients was not specifically mentioned in the available case reports, the patients were young (less than 20 years old), presented with prolonged fever and other systemic symptoms and one case mentioned rapid resolution of the symptoms within 7 days of commencing supportive treatment [15,16]. The clinical course of these cases was similar to that of KFD in general, as well as the cases of KFD post COVID-19 vaccination.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi–Fujimoto Disease Post COVID-19 Vaccination: Case Report and Review of Literature

et al. 2021

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With the rapid development of various coronavirus disease 2019 (COVID-19) vaccines in a bid to counter and contain the COVID-19 pandemic, unusual and uncommon side effects of COVID-19 vaccination have been increasingly reported in the literature. Ipsilateral lymphadenopathy is a fairly common side effect of vaccination of any kind, with its etiology most commonly related to reactive lymphadenopathy. However, Kikuchi–Fujimoto Disease (KFD) or necrotizing histiocytic lymphadenitis is rarely observed post-vaccination, with only one other case of KFD post COVID-19 vaccination reported to date. We report two more cases of KFD post COVID-19 vaccination in the Asian population, highlighting the clinical course and salient clinical, radiological and histologic findings. In addition, we provide a literature review of the existing cases of lymphadenopathy post COVID-19 vaccination with cytologic and/or histologic correlation.

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“…More recently, six cases of KFD were described after COVID-19, the main features of which are listed in Table 2 [8][9][10][11][12][13]. This patient was the first school-aged child among the six reported cases of KFD after COVID-19 infection, with an age of onset ranging from 5 to 43 years.…”

Section: Discussionmentioning

confidence: 94%

Kikuchi-Fujimoto Disease Following COVID-19 Infection in a 7-Year-Old Girl: A Case Report and Literature Review

Saito¹,

Suwa²,

Kaneko³

et al. 2022

Cureus

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The coronavirus disease 2019 symptoms in children are relatively mild and often do not require treatment. Nonetheless, complications caused by the immune response to COVID-19 in children are possible and diverse. We present the case of a 7-year-old girl with persistent fever and lymphadenopathy arising from SARS-CoV-2 infection, diagnosed with Kikuchi-Fujimoto Disease (KFD) on lymph node biopsy. KFD is a rare benign disease, clinically characterized by fever and tender cervical lymphadenopathy affecting posterior cervical lymph nodes. We also reviewed six previously reported cases of COVID-19-associated KFD that occurred in school-aged children and compared them with the present case. The clinical course of COVID-19-associated KFD was similar to that of previous reports of KFD with a favorable prognosis. This is the first report of a school-aged child developing KFD following SARS-CoV-2 infection. KFD should be considered when approaching patients with hyperinflammatory states who present with prolonged fever and cervical lymphadenopathy after COVID-19.

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COVID‐19 in a case with Kikuchi‐Fujimoto disease

Cited by 16 publications

References 7 publications

Kikuchi-Fujimoto disease following SARS CoV2 vaccination: Case report

Kikuchi-Fujimoto disease following SARS CoV2 vaccination: Case report

Kikuchi–Fujimoto Disease Post COVID-19 Vaccination: Case Report and Review of Literature

Kikuchi-Fujimoto Disease Following COVID-19 Infection in a 7-Year-Old Girl: A Case Report and Literature Review

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