Kikuchi–Fujimoto Disease Post COVID-19 Vaccination: Case Report and Review of Literature

Tan, Hui; Hue, Susan Swee-Shan; Wee, Aileen; See, Kay Choong

doi:10.3390/vaccines9111251

Cited by 30 publications

(50 citation statements)

References 16 publications

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“…In a study by Tan et al, the authors described the main features of previously published cases of lymphadenopathy following vaccination against COVID-19 [ 7 ]. The sites most involved were the axillary, supraclavicular and cervical lymph nodes ipsilateral to the vaccination site with reactive follicular hyperplasia or reactive lymphadenopathy on cytologic or histologic findings, and mainly there were reported after mRNA-based vaccines.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Kikuchi-Fujimoto's Disease or Histiocytic Necrotizing Lymphadenitis Following mRNA COVID-19 Vaccination: A Rare Case

Daghri¹,

Belmoufid²,

Rami³

et al. 2022

Cureus

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Kikuchi-Fujimoto disease (KFD), also known as necrotizing histiocytic lymphadenopathy, is a rare and benign lymph node disorder that mainly occurs in young women. It is clinically characterized by fever with tender and painful cervical lymphadenopathy mostly; however, all areas of lymph nodes can be involved. This disorder is often mistaken for malignant lymphoma or infection. The precise pathophysiology of KFD remains unknown, but it is theorized that it may be post-viral or associated with an autoimmune disease. The diagnosis is based on the histological analysis of the excised involved lymph node. The treatment is mainly supportive with favorable outcomes within a few weeks or months. In this case, we present a 24-year-old woman without a past medical history, who consulted for painful bilateral cervical lymphadenopathy associated with fever that has been evolving for one month following the coronavirus disease 2019 (COVID-19) vaccination. The initial diagnostic workup was performed and the diagnosis of KFD was confirmed based on the histopathological findings of the excised lymphadenopathy. Therapeutic management was based on oral corticosteroid treatment with clinical and radiological improvement after a few days without recurrence during follow-up. This article aims to report a rare case of KFD in a patient after receiving the messenger ribonucleic acid (mRNA)-based COVID-19 vaccine. Therefore, this case highlights the possible association between COVID-19 vaccination and KFD and this should be considered in the differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…More recently in the coronavirus disease 2019 (COVID-19) pandemic, few cases of KFD after infection have been reported [ 3 , 4 ]. However, to our knowledge, only four cases of KFD following vaccination against COVID-19 have been described to date [ 5 - 7 ].…”

Section: Introductionmentioning

confidence: 99%

Kikuchi-Fujimoto's Disease or Histiocytic Necrotizing Lymphadenitis Following mRNA COVID-19 Vaccination: A Rare Case

Daghri¹,

Belmoufid²,

Rami³

et al. 2022

Cureus

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“…Three of the patients developed KFD after receiving only the first dose of the vaccine, while the other developed KFD after the second dose. All of the patients had a good prognosis with resolution of symptoms [ 13 – 15 ] . There have been sporadic reports of cases of KFD following administration of the influenza vaccine, the human papilloma virus vaccine and the Japanese encephalitis vaccine [ 16 , 17 ] , although none of these are mRNA vaccines.…”

Section: Discussionmentioning

confidence: 99%

A Transient Inflammatory Reaction with a B-Cell Lymphoid Infiltrate and Dysplastic Bone Marrow Changes Associated with the BNT162b2 COVID-19 Vaccine

Vronsky

Hershkowitz

Hershko

et al. 2022

European Journal of Case Reports in Internal Medicine

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COVID-19 vaccines were introduced soon after the COVID-19 pandemic emerged in 2020. Various side effects were reported worldwide, including several types of common systemic side effects such as fever and general fatigue. Reports of other rare manifestations also emerged. We report the case of an adult male with a rare systemic syndrome mimicking lymphoma after he had received the first dose of an mRNA-based COVID-19 vaccine. After nearly 6 months of investigation with suspicion for an infection or malignancy, all symptoms resolved, laboratory tests normalized, and imaging showed no sign of active disease.

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“…Given this peculiarity, patients who have undergone treatment for unilateral breast cancer should be vaccinated in the contralateral deltoid to avoid unnecessary lymph node biopsies. There is also clinical confirmation of an ipsilateral lymphadenopathy following vaccination with mRNA-based vaccines [20], and two case reports of necrotizing histiocytic lymphadenitis (Kikuchi-Fujimoto Disease) after Pfizer/BioNTech COVID-19 vaccine injection [21].…”

Section: From Deltoid Muscle To Axillary Lymph Nodesmentioning

confidence: 91%

mRNA COVID-19 Vaccines and Long-Lived Plasma Cells: A Complicated Relationship

Giannotta

2021

Vaccines

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mRNA COVID-19 vaccines have hegemonized the world market, and their administration to the population promises to stop the pandemic. However, the waning of the humoral immune response, which does not seem to last so many months after the completion of the vaccination program, has led us to study the molecular immunological mechanisms of waning immunity in the case of mRNA COVID-19 vaccines. We consulted the published scientific literature and from the few articles we found, we were convinced that there is an immunological memory problem after vaccination. Although mRNA vaccines have been demonstrated to induce antigen-specific memory B cells (MBCs) in the human population, there is no evidence that these vaccines induce the production of long-lived plasma cells (LLPCs), in a SARS-CoV-2 virus naïve population. This obstacle, in our point of view, is caused by the presence, in almost all subjects, of a cellular T and B cross-reactive memory produced during past exposures to the common cold coronaviruses. Due to this interference, it is difficult for a vaccination with the Spike protein alone, without adjuvants capable of prolonging the late phase of the generation of the immunological memory, to be able to determine the production of protective LLPCs. This would explain the possibility of previously and completely vaccinated subjects to become infected, already 4–6 months after the completion of the vaccination cycle.

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Kikuchi–Fujimoto Disease Post COVID-19 Vaccination: Case Report and Review of Literature

Cited by 30 publications

References 16 publications

Kikuchi-Fujimoto's Disease or Histiocytic Necrotizing Lymphadenitis Following mRNA COVID-19 Vaccination: A Rare Case

Kikuchi-Fujimoto's Disease or Histiocytic Necrotizing Lymphadenitis Following mRNA COVID-19 Vaccination: A Rare Case

A Transient Inflammatory Reaction with a B-Cell Lymphoid Infiltrate and Dysplastic Bone Marrow Changes Associated with the BNT162b2 COVID-19 Vaccine

mRNA COVID-19 Vaccines and Long-Lived Plasma Cells: A Complicated Relationship

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