Coumarins from Brosimum gaudichaudii

Vilegas, Wagner; Pozetti, Gilberto Luiz; Vilegas, Janete Harumi Yariwake

doi:10.1021/np50093a015

Cited by 39 publications

(25 citation statements)

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“…84), sob a forma de gotículas. Vilegas et al (1993), em ensaios fitoquímicos de B. gaudichaudii, ressaltaram a presença marcante de terpenóides, substâncias estas de natureza lipídica.…”

Section: Resultsunclassified

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Morfoanatomia e histoquímica de Brosimum gaudichaudii Trécul (Moraceae)

2007

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RESUMO -(Morfoanatomia e histoquímica de Brosimum gaudichaudii Trécul (Moraceae)). Brosimum gaudichaudii, conhecida como mamacadela, é espécie comum nos cerrados, com grande valor na medicina popular e na indústria de medicamentos. A casca da raiz e do caule é empregada no tratamento do vitiligo, sendo o bergapteno e psoraleno, duas furanocumarinas, responsáveis pela ação farmacológica. Neste trabalho são apresentadas a caracterização morfoanatômica e a histoquímica de órgãos vegetativos de B. gaudichaudii, com informações sobre o embrião e o desenvolvimento pós-seminal. Amostras foram processadas segundo técnicas usuais em anatomia e ultra-estrutura vegetal. O embrião é do tipo total e invaginado, a plântula cripto-hipogéia e o sistema radicular do tirodendro é composto por raiz primária pouco desenvolvida em relação às raízes laterais. Plantas adultas apresentam raízes gemíferas longas, plagiotrópicas originando ramos caulinares aéreos; tais raízes possuem periderme com súber desenvolvido e floema secundário abundante em relação ao xilema, sendo facilmente destacados quando manipulados. O caule jovem e a folha apresentam epiderme unisseriada, grande densidade de tricomas tectores unicelulares e tricomas glandulares. Laticíferos não-articulados ramificados ocorrem em todos os órgãos, podendo invadir os elementos de vaso. Idioblastos fenólicos ocorrem em abundância em todos tecidos e órgãos analisados. O valor das características anatômicas observadas no controle de qualidade da droga é discutido. Palavras-chave:Brosimum gaudichaudii, idioblastos fenólicos, laticíferos, mamacadela, raízes gemíferas ABSTRACT -(Morphoanatomy and histochemistry of the Brosimum gaudichaudii Trécul (Moraceae)). Brosimum gaudichaudii known as "mamacadela" is a common cerrado species with a great importance on medicine folk and in the pharmaceutical industry. The bark of the root and stem is used on the treatment of "vitiligo" being the bergapten and psoralen two furocoumarins responsible for pharmacological activity. This work presents the morphoanatomical and histochemical characterization of the vegetative organs of B. gaudichaudii, with information about its embryo and post-seminal development. Samples were processed by usual techniques of plant anatomy and ultra-structure. The embryo is of the total type and invaginate, the seedling is crypto-hypogeal and the tirodentro's radicular system is composed by primary root that is not always well developed when compared to other roots that probably are derived of the hypocotyl which have greater size. The adult plants present long shoot bud-forming roots and plagiotropics origining with air branch. These roots present a periderm with developed phellem and secondary phloem more developed than xylem, being both easily eminent when manipulated. The stem and the leaf show unisseriate epidermis with a high density of unicellular non-glandular trichomes and glandular trichomes. The laticiferous are branched and non-articulate, occurring at all organs mostly frequently inside of the vessel elem...

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Section: Resultsunclassified

“…biologicamente ativas (Pozetti 1969;Elisabetsky & Castilhos 1990;Vilegas et al 1993;Shirota et al 1997;Torres et al 1997;Alcântara et al 2000;Takashima & Ohsaki 2001;Takashima et al 2002).…”

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Morfoanatomia e histoquímica de Brosimum gaudichaudii Trécul (Moraceae)

2007

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“…The terpenoidal (Terp) fractions which contained mainly triterpenes and/or steroids were obtained by silica gel open-column preparative liquid chromatography (PLC) of the crude plant extracts and selected by NMR ( 1 H-or 13 C-) analysis of the mixture. Since that the avaiable amount of each hexanic extract obtained as above was very reduced (between 10-100 mg), all the PLC procedure was performed in reduced scale, utilizing glass Pasteur pipettes containing around 500 mg silicagel, and around 5 mL of each solvent for elution.…”

Section: Generalmentioning

confidence: 99%

“…Chromatographic data also supports these assignments, since the peak corresponding to 3e in the TIC has a lower tR than 3f in the same elution sequence as for the 3-OH terpenes. Glutinol acetate was identified by analysis of its fragmentation data and comparison with an authentic sample of simiarenol, isolated from Dorstenia asaroides 13 . Despite the lupane-type ring E of the latter, which leads to some characteristic peaks related to the isopropyl group, both glutinol and simiarenol have great similarities in their MS spectra due to the similar structure of rings A to D 14 , the most important feature being the base peak at m/z 274, followed by a (274-Me) peak at m/z 259, which characterizes ∆ 5 -unsaturated skeleta 10 .…”

Section: Identification Of the Compoundsmentioning

confidence: 99%

Further triterpenes, steroids and furocoumarins from brazilian medicinal plants of dorstenia genus (moraceae)

Vilegas¹,

Lanças²,

Vilegas³

et al. 1997

J. Braz. Chem. Soc.

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“…Posle ovih početnih ex-situ merenja usledio je veći broj in-situ studija adsorpcije CO na niskoindeksnim ravnima platine [48][49][50].…”

Section: Reakcije Izdvajanja I Oksidacije Vodonika (Vodonična Reakcijunclassified

The influence of the surface morphology of platinum materials on the electrocatalytic activity in fuel cells

Tripković¹

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Coumarins from Brosimum gaudichaudii

Abstract: The new coumarin, (+j-(2'S,3'/?)-3-hydroxymarmesin [1], was isolated from the aqueous fraction of the EtOH extract of the root bark of Brosimum gaudichaudii (Moraceae).

Cited by 39 publications

References 2 publications

Morfoanatomia e histoquímica de Brosimum gaudichaudii Trécul (Moraceae)

Morfoanatomia e histoquímica de Brosimum gaudichaudii Trécul (Moraceae)

Further triterpenes, steroids and furocoumarins from brazilian medicinal plants of dorstenia genus (moraceae)

The influence of the surface morphology of platinum materials on the electrocatalytic activity in fuel cells

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