Could COVID-19 induce remission of acute leukemia?

Kandeel, Eman Z.; Refaat, Lobna; Abdelfatah, Raafat; Samra, Mohamed; Bayoumi, Ahmed; Abdellateif, Mona S.; Abdel-Hady, Hend; Ali, Mohamed; Khafagy, Medhat

doi:10.1080/16078454.2021.1992117

Cited by 24 publications

(19 citation statements)

References 10 publications

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“…The surprised clinicians who reported the disappearance of all evidence of hematological malignancy in two patients who presented with acute leukemia concomitantly with COVID-19 pneumonia and had only supportive care until recovery from COVID-19 asked if COVID-19 could induce remission of acute leukemia and demanded investigations to find an explanation for such regression that is associated with infection with the hope that such investigations will lead to an understanding of the immunological mechanisms and consequently to the discovery of a new therapeutic modality for patients with hematological malignancies. 21 And such investigation which they demanded now furnishes us with the capacity to answer their question.…”

Section: Discussionmentioning

confidence: 99%

“…And the fact that all evidence of hematological malignancy disappeared in two patients who presented with acute myeloid leukemia and relapsed acute lymphoblastic leukemia concomitantly with COVID-19 pneumonia despite the fact that they chose to have only supportive care until recovery from COVID-19 demonstrates that such cancers are also diseases that belong to the immunological spectrum of COVID-19. 21…”

Section: All Diseases Which Have Already Been Brought About Through C...mentioning

confidence: 99%

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The immunological nature of the pathological effects of SARS-CoV-2 and other pathogens

Ola¹

2022

Preprint

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The results of the investigation of the exact nature of the mechanisms that ensure the organism's survival in the face of the pathogen's pathological effects reveal those severe pathological manifestations that are temporally linked to a pathogen, such as those which appear in COVID-19 patients, to be manifestations of different diseases which are brought about through the same pathway under the influence of different causes which include the pathogen. Since the single pathway through which all of such diseases, which have the same "immunological nature," are brought about must be blocked for the attenuation of the influence of the pathogen to bring about the remission of the disease it causes, such diseases will undergo simultaneous remission when conditions permit immune mechanisms to attenuate the causative influence of the pathogen. Therefore, when conditions do not permit immune mechanisms to attenuate the causative influence under which any of the diseases in the same "immunological spectrum" as the disease the pathogen causes is produced through the shared pathway, the manifestations of such diseases that are linked with the pathogen will persist despite treatments that reduce pathogen load. In the absence of these results, such persistence was thought to be a consequence of the pathogen’s resistance to treatment and when it occurs in the absence of the pathogen, to be a consequence of an autoimmune response to pathogen mimicry. These results throw light on the different immunological phenomena which include those that inspired variolation and vaccination, remissions that are temporally linked with infection, the multiorgan manifestations that are seen in COVID-19 as well as long COVID.

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Section: Discussionmentioning

confidence: 99%

Section: All Diseases Which Have Already Been Brought About Through C...mentioning

confidence: 99%

The immunological nature of the pathological effects of SARS-CoV-2 and other pathogens

Ola¹

2022

Preprint

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“…The surprising clinical improvement of our case without any changes in his lifestyle may suggest an antineoplastic role for SARS-CoV-2 infection, as if the virus had acted as an oncolytic agent which previously seen in transient remission of natural killer cell and Hodgkin lymphoma. 7,10,11 In another study, Kandeel et al 12 demonstrated remission of two cases of acute myeloid leukemia and acute lymphoid leukemia after COVID-19 pneumonia due to evoking an anti-tumor immune response through natural killer cells activation by cytokine releasing or cross-reactivity of the virus-specific T cells with tumor antigens.…”

Section: Discussionmentioning

confidence: 99%

Oncolytic effect of SARS‐CoV‐2 in a patient with mycosis fungoides: A case report

Ohadi

Hosseinzadeh²,

Dadkhahfar³

et al. 2022

Clinical Case Reports

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The most common variant of cutaneous T‐cell lymphomas (CTCL) is mycosis fungoides (MF). Patients with MF often experience a chronic course of disease. The spontaneous regression (SR) of MF is rare, and the factors that predict SR have not been recognized yet. Here, we are reporting a case of persistent MF who had prominent remission after COVID‐19. This case report supports the possible antineoplastic effect of SARS‐CoV‐2. Understanding the underlying etiology of such effect can result in development of new target therapies for MF.

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“…These results have pointed us in the direction of what should be our topmost research priority if we will put an end to deaths from COVID-19 which have already surpassed 6 million, deaths from malignancies which, despite constituting most of the nearly 10 million deaths that cancer causes in the absence of treatments that are capable of curing cancer with precision, disappear in the phenomenon of remission along with pathological manifestations that occur in response to pathogens such as COVID-19 pneumonia 19 when conditions permit immune mechanisms to attenuate the influence of such pathogens. 7 And this priority is an illustration, in the shortest possible time, of the reality that leads us to a complete understanding of such conditions that give rise to immunity by means of prior infection and vaccination with pathogens or entities that are immunologically linked with them, conditions which permit dampening of the inflammation that occurs in response to pathogens and factors that are immunologically linked with them, such as SARS-CoV-2 and the sterile causes of the malignancies that disappear concomitantly with the manifestations of COVID-19, and asymptomatic hosting of such pathogens in phenomena which have demonstrated since the time of Pasteur that complete immunity is complete reduction of disease severity in spite of the prosperity of pathogens.…”

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confidence: 99%

The Nature of the Problem of Immunity and its Solution

Ola¹

2022

Preprint

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Tens of millions are killed by diseases in spite of the laudable effort of our healthcare teams every single year that the problem of the mechanisms of immunity, which are currently described as those that perceive pathogens to be invaders which must be detected and eliminated, remains unsolved. But this problem is not longstanding because of the complexity of its nature but rather because the theory of immunity was logically deduced from inflammatory phenomena in which phagocytosing cells that envelope and store foreign entities are mobilized to sites of cell death even in the absence of pathogens. While the nature of immunity has been seen in the light of these logical deductions as defence against pathogens, when it really is survival in the face of pathological manifestations that occur in response not only to the effects of pathogens but also to the effects of sterile factors. An illustration of the reality in which immune mechanisms reduce the severity of diseases to ensure our survival in immunological phenomena reveals the nature of immunity to be the reduction of the severity of diseases in spite of the presence of their causes which occurs when conditions that permit such mechanisms to attenuate the influence of such causes on the pathological mechanisms that respond to the death of cells in inflammatory phenomena. And our topmost research priority now ought to be an illustration of reality which enables us to understand so well as to be able to stabilize such conditions that give rise to the immunity we obtain by means of infection and vaccination by permitting immune mechanisms to attenuate the influence on pathological mechanisms through which pathogens and sterile factors cause diseases so that the manifestations of such diseases fail to appear irrespective of how high their loads in the body may be.

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Could COVID-19 induce remission of acute leukemia?

Cited by 24 publications

References 10 publications

The immunological nature of the pathological effects of SARS-CoV-2 and other pathogens

The immunological nature of the pathological effects of SARS-CoV-2 and other pathogens

Oncolytic effect of SARS‐CoV‐2 in a patient with mycosis fungoides: A case report

The Nature of the Problem of Immunity and its Solution

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