Oncolytic effect of SARS‐CoV‐2 in a patient with mycosis fungoides: A case report

Ohadi, Laya; Hosseinzadeh, Fatemeh; Dadkhahfar, Sahar; Nasiri, Soheila

doi:10.1002/ccr3.5682

Cited by 9 publications

(6 citation statements)

References 17 publications

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“…Interestingly, since then and after a 1-year follow-up the patient was considered in persistent and complete remission, with no need of any immunosuppressive therapy. Prior to this case report, remission or significant improvement of chronic diseases following Covid-19 have been reported for oncohematological diseases including mycosis fungoides, follicular and Hodgkin lymphoma ( 22 – 24 ), thus suggesting a potential beneficial influence of the virus even in the inflammatory response involved in cancer biology. Ohadi et al.…”

Section: Discussionmentioning

confidence: 72%

“…Ohadi et al. suggested a possible “oncolytic effect” of SARS-CoV-2 infection to be linked to the typical T-cell depletion induced by the virus itself ( 24 ), while Sollini et al. have speculated that in these cases SARS-CoV-2 infection might act as an immunotherapeutic agent by first causing a “flare phenomenon” and later an “abscopal effect”, eventually leading to complete resolution of the tumoral mass ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

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Case Report: Resolution of Lichen Planus Pemphigoides as an unexpected outcome of SARS-CoV-2 infection

et al. 2023

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It is well known that viral infections play a relevant role in inducing or protecting from autoimmune diseases, thus representing a major environmental factor in the disruption of the immune system in genetically susceptible individuals. Since the beginning of the Covid-19 pandemic a great number of clinical and epidemiological studies have demonstrated that SARS-CoV-2 infection is no exception to the rule by interfering on many different levels in the normal functioning of our immune system. Even though a growing number of case series and case reports has been cited in the literature linking the infection to the new onset of autoimmune diseases, to date very little has been reported concerning a possible correlation between the virus and the clinical resolution of any kind of autoimmune pathology. Here we describe an interesting case of abrupt and unexpected resolution of Lichen planus pemphigoides mucocutaneous lesions in a fully vaccinated patient after a mildly symptomatic SARS-CoV-2 respiratory infection and we speculate on the possible underlying mechanisms correlating the two events.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Case Report: Resolution of Lichen Planus Pemphigoides as an unexpected outcome of SARS-CoV-2 infection

et al. 2023

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“…Conversely, cutaneous drug reactions are not especially frequent in COVID-19 patients [ 18 ] and the use of personal protective equipment leads to only mild problems. Incidentally, there are occasional reports of partial or complete remission of mycosis fungoides and Sezary syndrome after SARS-CoV‑2 infection [ 19 , 20 ].…”

Section: Other Cutaneous Alterations Related To Covid-19 Infectionmentioning

confidence: 99%

Dermatopathology of COVID-19 infection and vaccination

Fernández‐Figueras

2022

Pathologie

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Background Many peculiar skin changes have been described in relation to both coronavirus disease 2019 (COVID-19) infection and vaccination. Objective This paper provides an overview of these dermatologic manifestations, focusing on their dermatopathological appearances. Results Most COVID-19 patients develop variegated maculopapular eruptions with a combination of histological patterns commonly including keratinocyte apoptosis and eosinophilia. Urticaria-like lesions often show a combination of spongiotic and lichenoid patterns and are more frequent in individuals with severe disease. Vesicular lesions can be disseminated; in some cases, they become pustular and in others show dyskeratosis and a peculiar form of ballooning. Some patients develop vesicular Grover disease on the trunk. Young patients with a strong immunological response can eliminate the virus easily but may develop chilblains as a consequence of the high interferon response. Conversely, older individuals with immunosenescence and a tendency toward hypercoagulability can present livedoid and ischemic areas. Regarding COVID-19 vaccination, hypersensitivity reactions are most frequent, including “COVID-arm.” Nonetheless, a combination of local and systemic cutaneous manifestations (reactogenicity) is commonly seen. Histopathologically, lichenoid and spongiotic changes and a variable number of eosinophils are typical of rashes characterized by papules and plaques. Other dermatological side effects of COVID-19 vaccination include lesions mimicking well-defined dermatoses such as lichen planus or bullous pemphigoid and triggering of collagenous diseases. Conclusion Well-characterized skin manifestations of coronavirus disease 2019 (COVID-19) include chilblains, livedo necrotic lesions, vesicular eruptions, urticarial lesions, and maculopapular eruptions. Hypersensitivity reactions are common after SARS-CoV‑2 mRNA vaccination. Vaccine reactions may also mimic other dermatosis such as bullous pemphigoid or lichen planus, stimulate herpes reactivation, or trigger the development of autoimmune diseases.

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“…However, while the majority of the literature is in support of this positive correlation between COVID-19 severity and cancer progression, a significant number of recent case reports about cancer remission during or after SARS-CoV-2 infection cannot remain undisputed. These cases concern a variety of cancer types including colorectal cancer, cutaneous T-cell lymphoma, EBV positive Hodgkin lymphoma, NK/T-cell lymphoma, follicular lymphoma, multiple myeloma and acute leukemia [ 114 , 115 , 116 , 117 , 118 , 119 , 120 ]. Direct oncolysis, immune system activation and epitope spreading are among the prevailing underlying mechanisms currently proposed for the SARS-CoV-2-mediated cancer suppressive effects [ 121 ].…”

Section: Covid-19 and Cancermentioning

confidence: 99%

COVID-19 vs. Cancer Immunosurveillance: A Game of Thrones within an Inflamed Microenviroment

Liapis

Baritaki

2022

Cancers

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The COVID-19 pandemic accounts for more than 500 million confirmed infections and over 6 million deaths worldwide in the last 2 years. SARS-CoV-2 causes a highly complex form of inflammation that affects the human organism both acutely and chronically. In the same line, cancer as an inflammation-induced and immune-editing disease appears to cross-react with immune system at different levels including early interactions during carcinogenesis and later cross-talks within the tumor microenvironment. With all that in mind, a reasonable question one might address is whether the SARS-CoV-2 infection and the derived “long lasting inflammatory status” that is frequently observed in patients, might affect the cancer immunosurveillance mechanisms and consequently their risk of developing cancer, as well as the tumor and immune cell behaviors within the inflamed microenvironment. On this context, this review intends to outline and discuss the existing knowledge on SARS-CoV-2-mediated immunomodulation under the prism of changes that might be able to interfere with cancer cell immunoescape and the overall tumor progression and response to conventional therapeutics. Our goal is to highlight a potential interplay between the COVID-19 immunopathology and cancer immune-microenvironment that may pave the way for thorough investigation in the future.

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Oncolytic effect of SARS‐CoV‐2 in a patient with mycosis fungoides: A case report

Cited by 9 publications

References 17 publications

Case Report: Resolution of Lichen Planus Pemphigoides as an unexpected outcome of SARS-CoV-2 infection

Case Report: Resolution of Lichen Planus Pemphigoides as an unexpected outcome of SARS-CoV-2 infection

Dermatopathology of COVID-19 infection and vaccination

COVID-19 vs. Cancer Immunosurveillance: A Game of Thrones within an Inflamed Microenviroment

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