The Nature of the Problem of Immunity and its Solution

Abstract

Tens of millions are killed by diseases in spite of the laudable effort of our healthcare teams every single year that the problem of the mechanisms of immunity, which are currently described as those that perceive pathogens to be invaders which must be detected and eliminated, remains unsolved. But this problem is not longstanding because of the complexity of its nature but rather because the theory of immunity was logically deduced from inflammatory phenomena in which phagocytosing cells that envelope and store foreign entities are mobilized to sites of cell death even in the absence of pathogens. While the nature of immunity has been seen in the light of these logical deductions as defence against pathogens, when it really is survival in the face of pathological manifestations that occur in response not only to the effects of pathogens but also to the effects of sterile factors. An illustration of the reality in which immune mechanisms reduce the severity of diseases to ensure our survival in immunological phenomena reveals the nature of immunity to be the reduction of the severity of diseases in spite of the presence of their causes which occurs when conditions that permit such mechanisms to attenuate the influence of such causes on the pathological mechanisms that respond to the death of cells in inflammatory phenomena. And our topmost research priority now ought to be an illustration of reality which enables us to understand so well as to be able to stabilize such conditions that give rise to the immunity we obtain by means of infection and vaccination by permitting immune mechanisms to attenuate the influence on pathological mechanisms through which pathogens and sterile factors cause diseases so that the manifestations of such diseases fail to appear irrespective of how high their loads in the body may be.

The Spectral Nature of COVID-19 and other Infectious Diseases

“…While the origin of the infectious disease lies essentially and solely in the presence of the pathogen as demonstrated in the reality that Pasteur's laboratory experiments illustrated, the reality which is beyond the reach of such laboratory experiments but which our thought experiments have yielded reveals that the origin of its virulence, its ability to cause disease, does not lie in direct effects that permit the disease it causes to occur in isolation in every single one of the infected but rather in an influence on pathological mechanisms that results in its co-occurrence of this disease with other diseases in its immunological spectrum, diseases which may include both infectious diseases and those that are caused by sterile etiological factors. 11 Some weeks ago (precisely on the 19th of July, 2022), a distinguished pediatrician and infectious disease researcher, Dr. Jane Achan, after reading my interpretation 8 of the observations from a study that highlights the importance of understanding the potential clinical and therapeutic implications of overlapping co-infections, 12 did not hesitate to assert that a plausible explanation for the potential mechanisms has indeed been provided.…”

What Predicts the Victims of the Severe Pathological Manifestations in Infections?

“…The pathogen can be hosted asymptomatically or with mild illness upon sufficient exposure to the immunological conditions that permit the obstruction of the pathway through which the diseases in the infectious disease's immunological spectrum are brought about by the response of pathological mechanisms to the pathogen and the causes of the different diseases in the spectrum. 15,16,17 2. In such mild and asymptomatic cases in which the disease severity has been reduced by obstructing the pathway through which pathological mechanisms respond to the influence of the causes of such diseases in the infectious disease's immunological spectrum, loads of the pathogen (such as the load of SARS-CoV-2) may be higher than those observed in cases that are severe 18 because the conditions that permit such obstruction by immunological mechanisms have disappeared in such severe cases.…”

“…If such a response has not occurred for the purpose of eliminating the pathogen as logically deduced by the defence theory of immunity but rather for the purpose of destroying the tissues in order to achieve the goal for which such pathological mechanisms took control of the genome at some point in our evolutionary history, 17 the consequence that emerges must be the following.…”

“…Upon comparing the data of experience with the result thus obtained, we find that this consequence is already represented in the findings of our experimental scientists. It was concluded on the foundation of the logically deduced defence theory of immunity which describes the immunological mechanisms that protect us from infectious diseases as pathogeneliminating mechanisms on the foundation of the attack mechanism theory of infectious disease pathogenesis 17 that antibodies which are produced against those ubiquitously expressed cytokines that are known as type-1 interferons are mistakenly produced against the organism's own constituents. 19 And when it was observed that the production of such antibodies, which were named autoantibodies on the foundation of the defence theory of immunity, was triggered by cells that are referred to as "cancer-initiating" cells on the basis of their differentiation into the bulk of the tumor mass, the ad hoc hypothesis that accounted for this unexpected finding described it as a phenomenon that originates in "viral mimicry."…”

The Nature of Malignant Cancer and its hitherto Elusive Cure

“…32 How to delineate where along the spectrum of metastatic disease a patient's cancer really lies has therefore remained an open question in the absence of knowledge of the spectral nature of malignant cancer and work that will integrate molecular and genetic factors to enable such delineation is still being urged. 32,33 But as soon as we realize that the malignant manifestations only appear to have their origin in the metastatic process because process of tumorigenesis has its origin in the response of pathological mechanisms to the causes of the different spectral diseases that co-manifest when such causes are present at the time of disappearance of the conditions that give rise to immunity 34,35 by obstructing the pathway through which such a pathological response occurs, we realize that where work needs to be done is the illustration of the context in which such conditions bring about not only the disappearance of tumors as well as the malignant pathological manifestations that cause the deaths of cancer patients which include those of the pathogens that cause those infectious diseases which contribute to the increased risk of death in cancer patients.…”