The immunological nature of the pathological effects of SARS-CoV-2 and other pathogens

Ola, Paul

doi:10.31219/osf.io/reh2t

Cited by 7 publications

(14 citation statements)

References 24 publications

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“…The results from an illustration of reality, which enabled us to account for monkeypox cases with no established travel links to Africa 4 which have emerged in multiple countries in unlinked clusters 7 in a recent paper, 8 yielded these two phenomena through which immune mechanisms protect humans from pathological manifestations that appear in those who are infected with pathogens by means of prior infection with such pathogens and vaccination as consequences in an earlier paper. 9 And the correspondence of these results with experience demonstrates their source as knowledge of reality which is capable of leading us to the origin of these phenomena in this paper.…”

Section: Introductionsupporting

confidence: 55%

The Origin of Immunity by Means of Prior Infection and Vaccination with Implications for the Origin of Species

Ola¹

2022

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The expectation that vaccines would solve the COVID-19 problem through herd immunity, which followed logical deductions from inflammatory phenomena in which Mechnikov and his contemporaries described immunity as originating from the elimination of pathogens by a system of cells and substances which has since been named the immune system which would prevent onward transmission of the pathogen, has failed to find representation in reality. But upon illustrating the reality in which the immunological phenomena through which immune mechanisms protect us from the pathological manifestations that occur in response to the pathogen, they were found to be brought about by the attenuation of the causative influence of the same pathogen from a prior infection and an entity that is immunologically-linked with the pathogen from vaccination so that the single pathway through which such pathological manifestations are brought in response to these influences are blocked and infection with the pathogen remains asymptomatic for as long as either or both of the conditions that hive rise to different but connected paths to immunity persist. Rather than asymptomatically hosted variants and subvariants to have become masters in the art of escaping the system which we have described as immune for in the absence of knowledge of reality for severe manifestations to occur in both the vaccinated and unvaccinated or to have become more transmissible for surges of COVID-19 hospitalizations and death to occur, it is these protective conditions that give rise to immunity that needs to disappear. And the higher likelihood of one path disappearing in the unvaccinated than both disappearing in the vaccinated explains why the unvaccinated are at greater risk of such unfortunate events. If we will put an end to such deaths which claimed the lives of millions prematurely during this pandemic and prevent those which may decimate our populations if pathological manifestations such as malignancies should appear catastrophically in our species as they did in Tasmanian devils, an understanding of the immunological nature of the pathological effects of the pathogens that are linked with these manifestations, which will enable us to keep both conditions stable in the vaccinated until eradication occurs, must be our topmost research priority now.

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Section: Introductionsupporting

confidence: 55%

The Origin of Immunity by Means of Prior Infection and Vaccination with Implications for the Origin of Species

Ola¹

2022

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“…Upon illustrating reality, I found the origin of immunity in conditions that permit immune mechanisms to attenuate the influence of the pathogen on pathological mechanisms so that even when the loads of the pathogen in different individuals are exactly the same, disease severity is reduced by different degrees in such individuals if the pathogen's influence is unequally reduced in strength in them. 7 3. Since the manifestations of the disease that a harmful agent causes will not be reduced in severity at all in those who are not immune to the disease and therefore are unable to resist the disease at all, they will go down with the manifestations of the disease while others who are similarly exposed to such a harmful agent survive either because the severity of the disease is completely reduced in them, in which case the disease is asymptomatic, or because severity is so reduced that manifestations become more or less rendered moderate or mild depending on the degree of the immunity in such symptomatic survivors.…”

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confidence: 99%

“…Pasteur and his co-workers assumed that the mechanism by which complete immunity is obtained by means of vaccination with pathogens is that which eliminates such pathogens completely when upon illustrating the reality in which immune mechanisms bring about such immunity, I found complete immunity to have its origin in conditions that permit the influence of the pathogen on pathological mechanisms to be completely attenuated so that pathological manifestations are not brought about in response to the pathogen at all irrespective of high the load of such a pathogen may become. 7,8 5. Instead of evidence of the inability of pathogens to spread in an immune organism which Pasteur and co-workers expected on the basis of the logical deduction that the mechanisms that bring about immunity are those that defend the host by destroying pathogens which followed the logical deduction that the mechanism by which pathogens cause diseases is one in which the host is attacked, what they found was the consequence of the new theory of immunity that has emerged from the reality we have illustrated so farthat pathogens must necessarily develop very well in animals that enjoy complete immunity because the influence through which such pathogens cause diseases has been completely attenuated in them.…”

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confidence: 99%

“…The reduction in the severity of the pathological manifestations of the effects of pathogens is not brought about by cells and substances that make up the system that is referred to as immune on the basis of his deductions but rather by tolerance mechanisms which we normally do not think of as "immune" because they bring about immunity without eliminating pathogens. 7,9 Indeed, in bats which are famous for having high loads of viruses in their sera or tissues without the manifestations of the diseases that such viruses cause in humans and other animals, the studies of Matae Ahn and coworkers revealed a mechanism that dampens the inflammation that occurs in response to infections with three different zoonotic RNA viruses as well as sterile factors without reducing the viral loads in those cells that are referred to as "immune" cells. 10 The consequence of the absence of connection between the question "How is the pathogen eliminated from the organism?"…”

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confidence: 99%

“…18 But the reality we have so far illustrated has revealed that the origin of the protection in which this pathological response is turned off to be conditions that permit immune mechanisms to reduce the severity of the pathological manifestations that are brought about through such responses so that upon the disappearance of such conditions, the response appears to be a doubleedged sword when it is viewed as beneficial in the absence of knowledge of its pathological origin which we have uncovered by illustrating reality. And it is because sterile factors also exert influences on the source of this pathological response in which phagocytosing cells of Mechnikov are brought to the sites of cell death, those pathological mechanisms which we referred to as the gravity-like unobservable in another paper, 7 that the phenomenon of sterile inflammation (inflammation in the absence of infection) occurs.…”

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confidence: 99%

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The Nature of the Problem of Immunity and its Solution

Ola¹

2022

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Tens of millions are killed by diseases in spite of the laudable effort of our healthcare teams every single year that the problem of the mechanisms of immunity, which are currently described as those that perceive pathogens to be invaders which must be detected and eliminated, remains unsolved. But this problem is not longstanding because of the complexity of its nature but rather because the theory of immunity was logically deduced from inflammatory phenomena in which phagocytosing cells that envelope and store foreign entities are mobilized to sites of cell death even in the absence of pathogens. While the nature of immunity has been seen in the light of these logical deductions as defence against pathogens, when it really is survival in the face of pathological manifestations that occur in response not only to the effects of pathogens but also to the effects of sterile factors. An illustration of the reality in which immune mechanisms reduce the severity of diseases to ensure our survival in immunological phenomena reveals the nature of immunity to be the reduction of the severity of diseases in spite of the presence of their causes which occurs when conditions that permit such mechanisms to attenuate the influence of such causes on the pathological mechanisms that respond to the death of cells in inflammatory phenomena. And our topmost research priority now ought to be an illustration of reality which enables us to understand so well as to be able to stabilize such conditions that give rise to the immunity we obtain by means of infection and vaccination by permitting immune mechanisms to attenuate the influence on pathological mechanisms through which pathogens and sterile factors cause diseases so that the manifestations of such diseases fail to appear irrespective of how high their loads in the body may be.

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The origin of immunity by means of prior infection and vaccination with implications for the origin of species

Ola¹

2022

Preprint

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Reality has failed to agree with the expectation that vaccines will solve the COVID-19 problem by preventing onward transmission of the coronavirus known as SARS-CoV-2, which followed logical deductions from inflammatory phenomena in which Mechnikov and his contemporaries described immunity as originating from the elimination of pathogens by a system of cells and substances that has since been named the immune system. But upon illustrating the reality in which we are protected from the pathological manifestations that occur in response to the pathogen in immunological phenomena, it was found to be that in which the pathogen does not cause such pathological manifestations through effects that are due to its mere presence but rather through effects that are due to its influence on pathological mechanisms so that immune mechanisms do not protect us from such pathological manifestations by eliminating the pathogen but rather by making asymptomatic hosting of the pathogen possible. And such protection, which occurs in spite of the presence of the pathogen when the conditions from which it originates are present, is obtained by means of infection with the same pathogen through the attenuation of its

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The immunological nature of the pathological effects of SARS-CoV-2 and other pathogens

Cited by 7 publications

References 24 publications

The Origin of Immunity by Means of Prior Infection and Vaccination with Implications for the Origin of Species

The Origin of Immunity by Means of Prior Infection and Vaccination with Implications for the Origin of Species

The Nature of the Problem of Immunity and its Solution

The origin of immunity by means of prior infection and vaccination with implications for the origin of species

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