Correlation of cholesteatomas perimatrix thickness with patient's age

Dornelles, Cristina; Costa, Sady Selaimen da; Meurer, Luíse; Schweiger, Cláudia

doi:10.1016/s1808-8694(15)31250-7

Cited by 10 publications

(17 citation statements)

References 19 publications

(16 reference statements)

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“…They based their studies on histopathological components, perimatrix thickness and degree of inflammation between paediatric and adult CHS. Dornelles 14 et al showed no differences in the histopathological components of acquired CH in adults and children in contrast to the present study. Hypothetically, the presence of more fibrosis in adult CH suggests better control of infection and inflammation giving them better compliance in treatment.…”

Section: Discussioncontrasting

confidence: 94%

Acquired Cholesteatoma in Children and Adults - A Clinico-Pathological and Immunohistochemical Study of Its Characteristics

P¹,

Srinivas²

2017

jemds

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BACKGROUNDCholesteatoma (CH) is a bag-like cystic structure developing in the middle ear cleft, either following a retraction pocket or epithelial migration or metaplasia. It forms in Chronic Suppurative Otitis Media (CSOM) of attico-antral type. Though the pathogenesis of CH is same in adults and children, its clinical presentation is more aggressive in the latter. Many factors play their role in producing osteolytic changes in the walls of middle ear cleft. One among them is an evidence of cellular histochemical reactions initiated by enzymes, bacterial proteins and toxins liberated following lysis of the organism.The aim of this study is to compare the histopathological structure and immuno-histochemical characteristics of acquired cholesteatoma in children and adults.Study Design -Prospective clinical study in tertiary care centre.

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Section: Discussioncontrasting

confidence: 94%

Acquired Cholesteatoma in Children and Adults - A Clinico-Pathological and Immunohistochemical Study of Its Characteristics

P¹,

Srinivas²

2017

jemds

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“…Based on these findings, they suggested that the perimatrix was thicker and more active in pediatric cholesteatoma. In the study of Dornelles et al (9), the thickness of the perimatrix, which is the center of inflammatory reaction in pediatric and adult patients, was measured and the results differed between 27 and 1277 micrometer. Although the mean thickness of the perimatrix was higher in adult patients, moderate but reverse correlation was found between age and perimatrix thickness in correlation analyses.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, increased CD-31 immunopositivity and the number of microvessels were accepted to be biological markers of chelesteatoma activity. Dornelles et al compared 60 pediatric and 60 adult patients in their study and they found the density of CD-31 as 7 (4)(5)(6)(7)(8)(9)(10)(11) in the pediatric patient group and as 4 (0-10) in the adult patient group (5). They evaluated this difference to be statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Subepithelial Angiogenesis in Acquired Cholesteatoma between Pediatric and Adult Patients

Aslıer

Erdağ

Sarıoğlu

et al. 2015

Turk Arch Otorhinolaryngol

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Objective: The aim of this study was to compare subepithelial angiogenesis developing within the perimatrix of the cholesteatoma between pediatric and adult patients. Methods:Sixty-one patients who underwent mastoidectomy for the first intent because of chronic otitis media with cholesteatoma between 1993 and 2013 and from whom appropriate tissue specimens were taken were included in the study. The patients were classified in the pediatric patient group if they were under the age of 18 years and the adult patient group if they were 18 years and older. Immunohistochemical staining for CD-31 was performed on new sections taken during surgery and sections prepared from archived tissues in paraffin blocks. Results were compared between the groups.Results: A total of 61 patients, of whom 25 were pediatric and 36 were adult patients, were included in the study. The mean CD-31 immunopositive microvessel rates were 8.8 (3-15) and 6.61 (2-14) for the pediatric and adult patient groups, respectively. The difference between the groups was statistically significant (p=0.037). Correlation analysis showed a statistically significant negative correlation between the CD-31 immunopositive microvessel rates and age (p=0.036). Conclusion:Subepithelial angiogenesis developing within the perimatrix of the cholesteatoma of the pediatric patients was more expressed than that of the adult patients. Keywords

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“…Up to now, studies have shown inconsistent findings regarding the difference between cholesteatoma behavior among children and adults [3]. Yet, the histopathological differences in surgical specimens can explain different behaviors of cholesteatoma in the patients [8]. Therefore, the current study aims to compare the histopathological structure of acquired cholesteatoma in the patients undergoing tympanomastoidectomy.…”

Section: Introductionmentioning

confidence: 96%

“…Middle ear cholesteatoma can cause hearing loss and occasionally facial nerve palsy and it can recur after surgical treatment [7]. The only treatment known for cholesteatoma is tympanomastoidectomy which is done using two techniques, namely wall-down and wall-up [8]. Up to now, studies have shown inconsistent findings regarding the difference between cholesteatoma behavior among children and adults [3].…”

Section: Introductionmentioning

confidence: 99%

Comparison of histopathological characteristics and clinical behavior of acquired cholesteatoma

Shishegar

Ashraf

2015

MMJ

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Objective: Acquired cholesteatoma is a severe middle-ear pathology affecting both adults and children. The clinical behavior of cholesteatoma depends on the histopathological characteristics of the disease. The present study aimed to compare the histophathological characteristics of acquired cholesteatoma in patients who had undergone tympanomastoidectomy. Patients and Methods:This retrospective chart analysis was conducted on 370 patients who had undergone tympanomastoidectomy presenting with the pathological indication of cholesteatoma. All cholesteatoma specimens were collected intraoperatively and were preserved for histopathological examination. The patients were divided into two groups according to the histopathological findings: 1-patients with pure cholesteatoma 2-patients with cholesteatoma plus other pathologies. Then, the two groups were compared regarding the clinical variables, including age, gender, duration of disease, occurrence of relapse, and complications.Results: No significant difference was found between the two groups regarding the clinical variables. Nevertheless, the incidence of pure cholesteatoma was higher among the patients who had experienced the recurrence of the disease and underwent tympanomastoidectomy one more time. Conclusion:In the present study, no significant difference was observed between the two histopathologically different groups regarding the clinical variables, except for recurrence rate.

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Correlation of cholesteatomas perimatrix thickness with patient's age

Cited by 10 publications

References 19 publications

Acquired Cholesteatoma in Children and Adults - A Clinico-Pathological and Immunohistochemical Study of Its Characteristics

Acquired Cholesteatoma in Children and Adults - A Clinico-Pathological and Immunohistochemical Study of Its Characteristics

Assessment of Subepithelial Angiogenesis in Acquired Cholesteatoma between Pediatric and Adult Patients

Comparison of histopathological characteristics and clinical behavior of acquired cholesteatoma

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