Comparison of histopathological characteristics and clinical behavior of acquired cholesteatoma

Abstract

Objective: Acquired cholesteatoma is a severe middle-ear pathology affecting both adults and children. The clinical behavior of cholesteatoma depends on the histopathological characteristics of the disease. The present study aimed to compare the histophathological characteristics of acquired cholesteatoma in patients who had undergone tympanomastoidectomy. Patients and Methods:This retrospective chart analysis was conducted on 370 patients who had undergone tympanomastoidectomy presenting with the pathological indication of cholesteatoma. All cholesteatoma specimens were collected intraoperatively and were preserved for histopathological examination. The patients were divided into two groups according to the histopathological findings: 1-patients with pure cholesteatoma 2-patients with cholesteatoma plus other pathologies. Then, the two groups were compared regarding the clinical variables, including age, gender, duration of disease, occurrence of relapse, and complications.Results: No significant difference was found between the two groups regarding the clinical variables. Nevertheless, the incidence of pure cholesteatoma was higher among the patients who had experienced the recurrence of the disease and underwent tympanomastoidectomy one more time. Conclusion:In the present study, no significant difference was observed between the two histopathologically different groups regarding the clinical variables, except for recurrence rate.