Correlation Criteria Between Extramural Invasion of Blood Vessels and Immunohistochemical Markers in the Processes of Neovasculogenesis

Abstract

Establishing the treatment strategy for patients diagnosed with colorectal cancer is based on their imaging and immunohistochemical evaluation. Depending on the stage of tumor invasion and its aggressiveness, is individualized, surgical, oncological, or both treatment. The most important factor for establishing these protocols is the impact of the tumor on intra- and perilesional colorectal vasculature and implicitly on the process of vascular neoformation in the paraneoplastic syndrome. In this regard, we studied a group of patients, colonoscopically diagnosed with colorectal cancer. The study method was to compare the expression of CD34 tumor marker with EMVI (extramural vascular invasion) staging criteria. The results of our study were compared with the intraoperative aspects. In all cases studied tumor extension reached to at least intestinal muscle layer. We conclude that expression of the CD34 marker has always been increased in correlation with EMVI 3-4 stages. In 2 patients with EMVI score 2, the immunohistochemical marker expression was 6% above the maximum threshold. The expression of vascular endothelial proliferation marker is closely correlated with the EMVI score - these values increase proportionally. The use of both criteria for establishing neovasculogenesis, significantly increases the predictability of postoperative progression and long-term survival.

The Routine and Specialised Staining for the Histologic Evaluation of Autogenous Mandibular Bone Grafts An experimental study

“…This is in accordance with other authors who pointed out that angiogenesis vessels are more numerous in areas where the inflammatory infiltrate is more abundant [16]. Neoangiogenesis involves growth factors and endothelial cell migration and proliferation [17].…”

Immunohistochemical evaluation of autogenous mandibular bone grafts integration: An experimental study

“…Neoangiogenesis involves growth factors and endothelial cell migration and proliferation (D. HINGANU & al. [21]).…”

The Influence of Thymectomy Over Acetylcoline Antibody Anti-receptor Concentration and Over the Clinical Manifestations on Myasthenia Gravis Patients

“…Myasthenia gravis is an autoimmune disorder which presents a series of clinical manifestations which are generally motor, but there have been documented cases of patients with myasthenia gravis that presented non motor symptoms [1]. The hallmark of the disorder is muscle weakness, which typically worsens during physical exercise and improves upon rest [2,3]. Approximatively 80% of the patients presenting this affection test positive for Acetylcholine antibody anti-receptor.…”

“…Approximatively 80% of the patients presenting this affection test positive for Acetylcholine antibody anti-receptor. (AChR-ab) [3,4]. However, recent studies demonstrate that there is no direct correlation between AChR-ab titration and the appearance of generalized myasthenia gravis [5,6].…”