Coping with mild inflammatory catamenial acne

Abstract

Background: Acne is a multifactorial disease exhibiting distinct clinical presentations. Among them, the catamenial type is a matter of concern for young women. Some oral contraceptives may help without, however, clearing the skin condition. Aim:The present open study aimed at evaluating the effect of overnight applications of a paste made of petrolatum, 15% zinc oxide and 0.25% miconazole nitrate. Method: The split-face trial was conducted in 35 women. A non-medicated cream was used as control. Clinical evaluations and biometrological assessments on cyanoacrylate follicular biopsies were performed monthly for 3 months. Comedometry and the density in autofluorescent follicular casts were used as analytical parameters. In addition, the five most severe cases at inclusion were tested at the completion of the study for follicular bacterial viability using dual flow cytometry.

Dynamics of Skin Barrier Repair following Topical Applications of Miconazole Nitrate

“…The present fi ndings may explain in part the benefi cial effect of a miconazole nitrate paste on diaper dermatitis [25,26] and infl ammatory acne [27,28] . Indeed, skin capacitance imaging shows the close correspondence between the skin areas affected by infl ammation and altered barrier function in acne [36] .…”

“…Other topical formulations and some ions can help in correcting the excess of TEWL after damaging the SC [3,[19][20][21][22][23][24] . Previous studies have reported a benefi cial effect of a miconazole nitrate-containing paste in some infl ammatory dermatoses, even when fungal intervention did not appear to be involved [25][26][27][28] . We thus suspected that miconazole nitrate could have some biological effect other than its acknowledged antimicrobial effect.…”

High‐resolution epiluminescence colorimetry of striae distensae

“…Comparative reflectance colorimetric assessments were performed on the photographs using a Visi‐Chroma® VC‐100 (Biophotonics, Lessines, Belgium). This computer‐assisted device allows to measure colours on very small and delimited areas defined by the observer 19,20 . Measurements were performed in the CIELAB system with L*a*b* notifications 21 .…”

Cyclic Catamenial Dermatoses

“…A series of topical agents are usually effective for controlling catamenial acne [9]. In addition, suppression of both ovulation and postovulatory rises in progesterone levels is effective.…”