Dynamics of Skin Barrier Repair following Topical Applications of Miconazole Nitrate

Abstract

The skin barrier function (SBF) is an important aspect of skin biology, particularly in the elicitation of inflammation. The SBF recovery rate after tape stripping and surfactant challenge can be assessed by measuring the transepidermal water loss (TEWL). Previous clinical studies have shown some inflammatory effect after topical applications of miconazole. The aim of this study was to compare the effect of pastes (petrolatum and 15% zinc oxide) containing or not miconazole nitrate on controlled impaired SBF. Fifteen volunteers were enrolled. In each subject, successive cyanoacrylate skin surface strippings were harvested from 5 sites of the volar forearm until TEWL raised above 15 g/cm²/h on all test sites. In addition, one daily soak session with a 0.2% dishwashing liquid further damaged the SBF. Each of the test formulations was applied twice daily for 5 days at two dosages, namely 1 and 2 mg/cm², on randomized test sites. Another site remained untreated. TEWL was measured daily for 5 days. A fastened SBF repair was observed on all treated sites, particularly where the largest amount of the products had been applied. A faster SBF recovery rate was obtained at the site receiving the miconazole nitrate paste. We conclude that the occlusive effect of a paste helped mitigate SBF defect. The adjunction of miconazole nitrate improved the efficacy.

Chitin–glucan, a natural cell scaffold for skin moisturization and rejuvenation

“…The basic properties of humectancy and emmoliency are enhanced, and skin barrier properties, skin surface microrelief and tensile properties are improved. The chitinglucan polysaccharides deposited at the skin's surface seem to be an addition to the stratum corneum's natural molecular armamentum for retaining water and maintaining an adequate permeability barrier [32][33][34]. Our results also suggested additive effects of glycerine and chitin-glucan, as chitin-glucan seems to enhance and sustain the humectant and moisturizing effects of the glycerincontaining formulation.…”

Skin Efficacy and Biophysical Assessment of Glycerol-Containing Hydrocolloid Patches

“…An- In the present protocol, cyanoacrylate tapes were used to remove the upper stratum corneum layers. This stripping technique was chosen because it is easily performed, rather painless and generally considered as an adequate and standardized model for mechanically induced barrier impairment characterized by inflammation and increased TEWL values [8,27] . The lesions are superficial; the epidermal barrier is damaged but not breached [28,29] .…”

“…It is also known that the modulation of the transepidermal water gradient after tape stripping plays a crucial role [27,28,32,33] . Indeed, it was shown that skin occlusion with a water vapor-impermeable dressing after tape stripping delayed TEWL normalization and inhibited barrier recovery [34] .…”

Skin protection creams in medical settings: successful or evil?

“…It is likely that the combination of the 2 offending products used in the present study alter both the SC lipids and the skin barrier function [ 34 ]. The SPC are expected to exert a preventive effect that is different from products aiming at the skin barrier repair after degradation [ 35 - 37 ].…”