Cyclic Catamenial Dermatoses

Hermanns‐Lê, Trinh; Hermanns, Jean‐François; Lesuisse, Marianne; Pierard, Gérald

doi:10.1155/2013/156459

Cited by 15 publications

(14 citation statements)

References 19 publications

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“…Nguyen et al reported that 45% of cases had a history of exogenous exposure in their review of 89 cases. Autoimmunity is favored as many of these patients experience a flare with exposure to progesterone and cessation of symptoms with removal of progesterone . In addition, antibodies to progesterone have been showed in some patients …”

Section: Discussionmentioning

confidence: 99%

The histopathologic features of autoimmune progesterone dermatitis

2016

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Background:The histologic features of autoimmune progesterone dermatitis (APD) are generally non-specific and have been described only in brief case reports. We present a case of APD and review the literature with a focus on the histologic findings described. Methods: A review of the English literature on APD was performed using PubMed and MEDLINE. Results: A total of 39 patients, including our patient are included in this review. The most consistent histologic finding reported was a perivascular inflammatory infiltrate, being seen in 72% of cases. A non-specific or interstitial inflammatory infiltrate was described in 31% of the cases, with 41% having an eosinophilic component and 21% having a neutrophilic component mixed with the predominant lymphocytic infiltrate. Interface dermatitis was the second most common finding with 36% showing a mild to exaggerated interface dermatitis. Conclusion: Although histopathologic changes are non-specific, perivascular dermatitis with eosinophils and interface changes are common in APD.Keywords: autoimmune progesterone dermatitis, histopathology of autoimmune progesterone dermatitis, progesterone allergy, progesterone anaphylaxis James T, Ghaferi J, LaFond A. The histopathologic features of autoimmune progesterone dermatitis.

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Section: Discussionmentioning

confidence: 99%

The histopathologic features of autoimmune progesterone dermatitis

2016

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“…Circulating sex hormones (i.e ., estrogens, progesterone, and androgens) regulate skin homeostasis. Thus, cutaneous disease may be influenced by the menstrual cycle, specifically by hormonal modulation of skin cell activity (Hermanns-Le et al, 2013). The menstrual cycle is split into two phases: the follicular phase (dominated by estradiol) and the luteal phase (dominated by progesterone).…”

Section: Introductionmentioning

confidence: 99%

“…Estrogen is also involved in the regulation of ultraviolet (UV)-induced skin damage and pigmentation by inducing intraepidermal melanogenesis, which causes transient patchy hyperpigmentation around the eyelids prior to menstruation. The effect of progesterone on skin physiology is not well known (Farage et al, 2009, Hermanns-Le et al 2013, Stephens, 1997).…”

Section: Introductionmentioning

confidence: 99%

Catamenial dermatoses associated with autoimmune, inflammatory, and systemic diseases: A systematic review,,

Zachary

Fackler

Juhász

et al. 2019

International Journal of Women's Dermatology

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BackgroundSex hormones are important in female sexual physiology, growth, and homeostasis. Through skin receptors, sex hormones contribute to the dermatologic pathology known as catamenial dermatoses.ObjectiveThis study aims to summarize the literature on catamenial dermatoses and menses-induced exacerbations of chronic dermatoses.MethodsThis systematic review used the PRISMA method. PubMed was searched using the terms “menses” and “skin” in July 2018, and an assessment was conducted of the relevant literature on skin diseases related to non-pathologic menstruation, such as polycystic ovarian syndrome. Pathology associated with androgenetic acne was excluded from the study.ResultsA total of 102 studies with 1269 female patients were included. The most commonly reported primary catamenial dermatoses were autoimmune progesterone dermatitis and autoimmune estrogen dermatitis. The most commonly reported chronic skin disorders exacerbated by menses were psoriasis, Behcet’s disease, and eczematous dermatoses.ConclusionPhysicians should be aware of the nature of catamenial dermatoses and their presentation with normal sexual physiology. Patients with chronic dermatoses should be appropriately counseled on menstruation-related exacerbations. Further research needs to be conducted to determine the interplay between immune regulation and sex hormones in catamenial dermatoses and to elucidate effective therapies.

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“…Autoimmune progesterone dermatitis (APD) is a rare skin condition with a varying morphology, appearing on a monthly basis during the luteal phase of the menstrual cycle. Progesterone levels gradually rise after ovulation, reaching a peak concentration about 7 days before menstruation, then decreasing 1 to 2 days after menses, when there is a spontaneous resolution of APD …”

Section: Introductionmentioning

confidence: 99%

“…Sex hormones modulate the immune and inflammatory functions of cells, including mast cell degranulation . Several studies point to an autoimmune mechanism mediated by Th1 lymphocytes targeting endogenous progesterone, as in delayed hypersensitivity reactions . In women undergoing exogenous progesterone prior to APD diagnosis, Th2 cells and immunoglobulin IgE may also play a role…”

Section: Introductionmentioning

confidence: 99%

Autoimmune progesterone dermatitis: Case report of an unexpected treatment reaction

et al. 2016

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Autoimmune progesterone dermatitis (APD) is a rare skin condition with a varying morphology, which appears on a monthly basis during the luteal phase of the menstrual cycle and resolves spontaneously with the endogenous decrease in progesterone during menses. We present the case of 39-year-old multiparous Caucasian woman with generalised, self-limited urticaria in her perimenstrual period. APD was diagnosed in light of the cyclical nature of the symptoms. An intradermal test with the administration of 0.5 mg/mL of medroxyprogesterone acetate showed a positive result. She started using vaginal hormonal contraceptive that paradoxically exacerbate the symptoms, which ceased after the removal of the device. An oral combined contraceptive was initiated instead, with complete resolution of the symptoms. We share the case because of the rarity of the situation, emphasising the importance of a multidisciplinary team for differential diagnosis and patient follow up.

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Cyclic Catamenial Dermatoses

Cited by 15 publications

References 19 publications

The histopathologic features of autoimmune progesterone dermatitis

The histopathologic features of autoimmune progesterone dermatitis

Catamenial dermatoses associated with autoimmune, inflammatory, and systemic diseases: A systematic review,,

Autoimmune progesterone dermatitis: Case report of an unexpected treatment reaction

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