Controlled Imipramine Treatment of School Phobia

Recent advances in paediatric psychopharmacology: A brief overview

“…This is in contrast to the positive effects of imipramine in school phobia reported by the senior author (Gittleman- Klein and Klein, 1971) twenty years previously. Another controlled study of low dose (40-75 mg) clomipramine also failed to show efficacy for school phobia (Berney et al, 1981).…”

The Risk for Early-Adulthood Anxiety and Depressive Disorders in Adolescents With Anxiety and Depressive Disorders

“…Such relationships have been explored from various perspectives, including family-based, 7,8 biological, 9,10 pharmacologic, [11][12][13] and longitudinal approaches. [14][15][16][17][18][19][20][21][22] Only longitudinal research directly quantifies the risk for adult anxiety or depressive disorders faced by adolescents with anxiety or depression.…”

Use of Imipramine in Children with Intractable Asthma and Psychiatric Disorders: A Warning

“…The use of imipramine (IMI) seemed judicious because of its possible efficacy on the affective and asthmatic symptomatolo gy. A controlled study has suggested that IMI is effective in the treatment of separation anxiety disorder [4,5]. By the same token, several case series of asthmatic patients have reported on a potential therapeutic effect of tricyclics on asthmatic symptoms [6][7][8], Al though these were noncontrolled studies with multiple méthodologie flaws, similar conclusions were reached in careful animal studies which suggested that tricyclics have bronchiodilatory effects [9,10].…”