Imipramine is an established treatment for anxiety in adults. Some evidence also exists that it may be beneficial in children. Because of the frequent co-occurrence of anxiety and affective symptomatology in asthmatic children, a pilot study was undertaken to obtain clinical observations on the effects of imipramine on symptoms of asthma as well as those of separation anxiety and depression in children suffering from intractable asthma. The pilot trial was terminated because of medical complications after 6 patients participated.
Roche et al (Pediatrics 63:847, 1979) have provided a good clinical review of recent data on stimulant-induced growth disturbances in hyperkinetic children. They have clearly shown that substantial differences exist among published studies in methodology used, drug dosages employed, and measurement techniques cited. The clinician in the field needs this type of review to clarify the confusing reports on stimulant side effects.
We wish to make two points. The authors might have stressed that the stimulant drugs available may have differential growth suppression effects.
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