Controlled degradable chitosan/collagen composite scaffolds for application in nerve tissue regeneration

Si, Junzeng; Yang, Yong; Xiao, Xing; Yang, Feng; Shan, Peiyan

doi:10.1016/j.polymdegradstab.2019.05.023

Cited by 59 publications

(43 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The literature reports variable porosities from 60 to 90% for CS-based scaffold materials. 40 − 42 By freeze-drying at −20 °C, the porosity observed is consistent with authors Si et al and Radhika Rajasree et al, 43 , 44 whereas freezing at lower temperatures such as −80 °C (as opposed to −20 °C in this study) has also been reported to create high porosity. One possible explanation is that having a lower freezing temperature produces a faster freezing rate of CS.…”

Section: Discussionsupporting

confidence: 91%

Development and Characterization of a Biocomposite Material from Chitosan and New Zealand-Sourced Bovine-Derived Hydroxyapatite for Bone Regeneration

et al. 2020

View full text Add to dashboard Cite

A biocomposite scaffold was developed using chitosan (CS) and bovine-derived hydroxyapatite (BHA). The prepared CS–BHA biocomposite scaffold was characterized for its physiochemical and biological properties and compared against control BHA scaffolds to evaluate the effects of CS. Energy-dispersive X-ray analysis confirmed the elemental composition of the CS–BHA scaffold, which presented peaks for C and O from CS and Ca and P along with trace elements in the bovine bone such as Na, Mg, and Cl. Fourier transform infrared spectroscopy confirmed the presence of phosphate, hydroxyl, carbonate, and amide functional groups attributed to the CS and BHA present in the biocomposite scaffolds. The CS–BHA scaffolds demonstrated an interconnected porous structure with pore sizes ranging from 60 to 600 μm and a total porosity of ∼64–75%, as revealed by scanning electron microscopy and micro-CT analyses, respectively. Furthermore, thermogravimetric analysis revealed that the CS–BHA scaffold lost 70% of its weight when heated up to 1000 °C, which is characteristic of CS phase decomposition in the biocomposite. In vitro studies demonstrated that the CS–BHA scaffolds were biocompatible toward Saos-2 osteoblast-like cells, showing high cell viability and a significant increase in cell proliferation across the measured timepoints compared to the controls.

show abstract

Section: Discussionsupporting

confidence: 91%

Development and Characterization of a Biocomposite Material from Chitosan and New Zealand-Sourced Bovine-Derived Hydroxyapatite for Bone Regeneration

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Chitosan/collagen crosslinked hybrid scaffolds present better mechanical and degradation properties than their unitary systems separately, especially for the optimal ratio of 50/50 [162]. With good cytocompatibility, those scaffolds could be used for nerve tissue regeneration as they promote the attachment, migration and proliferation of Schwann cells [163]. Cellulose nanofibre-reinforced chitosan hydrogel is another example of biocomposite candidate for tissue engineering.…”

Section: • Tissue Engineeringmentioning

confidence: 99%

Marine-Derived Polymeric Materials and Biomimetics: An Overview

et al. 2020

View full text Add to dashboard Cite

The review covers recent literature on the ocean as both a source of biotechnological tools and as a source of bio-inspired materials. The emphasis is on marine biomacromolecules namely hyaluronic acid, chitin and chitosan, peptides, collagen, enzymes, polysaccharides from algae, and secondary metabolites like mycosporines. Their specific biological, physicochemical and structural properties together with relevant applications in biocomposite materials have been included. Additionally, it refers to the marine organisms as source of inspiration for the design and development of sustainable and functional (bio)materials. Marine biological functions that mimic reef fish mucus, marine adhesives and structural colouration are explained.

show abstract

“…Widespread as it is, collagen is easily obtainable and processable for applications in TE and can be fabricated into injectable gels, films, meshes, and porous scaffolds [ 17 , 18 , 19 , 20 ]. Porous scaffolds remain the most versatile applicable structure in TE, since it closely resembles the vital environment for cells [ 21 , 22 , 23 , 24 ]. Despite its unique properties, collagen alone exhibits neglible antimicrobial activity and requires modification to unlock its potential as cellular support in complex wounds [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds

et al. 2020

View full text Add to dashboard Cite

A highly porous scaffold is a desirable outcome in the field of tissue engineering. The porous structure mediates water-retaining properties that ensure good nutrient transportation as well as creates a suitable environment for cells. In this study, porous antibacterial collagenous scaffolds containing chitosan and selenium nanoparticles (SeNPs) as antibacterial agents were studied. The addition of antibacterial agents increased the application potential of the material for infected and chronic wounds. The morphology, swelling, biodegradation, and antibacterial activity of collagen-based scaffolds were characterized systematically to investigate the overall impact of the antibacterial additives. The additives visibly influenced the morphology, water-retaining properties as well as the stability of the materials in the presence of collagenase enzymes. Even at concentrations as low as 5 ppm of SeNPs, modified polymeric scaffolds showed considerable inhibition activity towards Gram-positive bacterial strains such as Staphylococcus aureus and methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis in a dose-dependent manner.

show abstract

Controlled degradable chitosan/collagen composite scaffolds for application in nerve tissue regeneration

Cited by 59 publications

References 49 publications

Development and Characterization of a Biocomposite Material from Chitosan and New Zealand-Sourced Bovine-Derived Hydroxyapatite for Bone Regeneration

Development and Characterization of a Biocomposite Material from Chitosan and New Zealand-Sourced Bovine-Derived Hydroxyapatite for Bone Regeneration

Marine-Derived Polymeric Materials and Biomimetics: An Overview

Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds

Contact Info

Product

Resources

About