The unique magnetic vortex structure allows ferrimagnetic vortex‐domain iron oxide nanorings to possess negligible remanence and large hysteresis loss, which not only promotes colloid stability but also maximizes the specific absorption rate. It overcomes the super‐paramagnetic limitation and allows a new class of nanoparticle agent to be designed for high‐performance thermal‐based biomedical applications.

A two-step chemical approach to synthesize high quality Fe 3 O 4 nanodisc is reported. The magnetic hyperthermia properties of the nanodisc and isotropic nanoparticles are investigated systematically. The results suggest that the nanodisc shows much higher specifi c absorption rate (SAR) than isotropic nanoparticles. This is attributed to the parallel alignment of nanodisc with respect to the alternating current magnetic fi eld, which is confi rmed by good agreement between experimental results and micromagnetic simulation. It is found that such parallel alignment could enhance the SAR value by a factor of ≈2 with respect to the randomly oriented case. The above results indicate that the nanodisc provides an excellent thermal seed for magnetic hyperthermia. This study sheds the light on the magnetic hyperthermia mechanism of magnetic nanodisc and it also opens the window to explore high effi ciency thermal seeds by controlling the orientation of magnetic nanostructures.

Various aspects of the theory and modeling of ion–molecule radiative association are discussed. A general formalism for evaluating the effective rate constant for radiative and collisional association is reviewed. The implementation of variable reaction coordinate transition state theory estimates within this formalism is described. A detailed discussion is given of the limiting cases of high and low stabilization efficiency. The basic validity of the algorithm is illustrated through sample calculations for the high efficiency limit. The low efficiency limit allows for the determination of binding energies which are independent of any transition state model. The relation between the predicted and observed temperature dependence in the low efficiency limit is explored. Sample calculations employing the general formalism illustrate the usefulness of this modeling in estimating the binding energy of the complex. Modest levels of quantum chemistry (e.g., MP2/6-31G*) are found to provide satisfactory estimates of the vibrational frequencies and intensities required in the modeling. Overall, the modeling provides estimated binding energies for the protonated acetone dimer, NO+...3-pentanone, and Al+...C6H6 complexes which agree with the available literature values to within 2 kcal/mol.

Although cGAS-STING–mediated DNA sensing in tumor cells or phagocytes is central for launching antitumor immunity, the role of intrinsic cGAS-STING activation in T cells remains unknown. Here, we observed that peripheral blood CD8+ T cells from patients with cancer showed remarkably compromised expression of the cGAS-STING cascade. We demonstrated that the cGAS-STING cascade in adoptively transferred CD8+ T cells was essential for antitumor immune responses in the context of T cell therapy in mice. Mechanistically, cell-autonomous cGAS and STING promoted the maintenance of stem cell–like CD8+ T cells, in part, by regulating the transcription factor TCF1 expression. Moreover, autocrine cGAS-STING–mediated type I interferon signaling augmented stem cell–like CD8+ T cell differentiation program mainly by restraining Akt activity. In addition, genomic DNA was selectively enriched in the cytosol of mouse CD8+ T cells upon in vitro and in vivo stimulation. STING agonism enhanced the formation of stem-like central memory CD8+ T cells from patients with cancer and potentiated antitumor responses of CAR-T cell therapy in a xenograft model. These findings advance our understanding of inherent cGAS-STING activation in T cells and provide insight into the development of improved T cell therapy by harnessing the cGAS-STING pathway for cancer immunotherapy.

Organosoluble polyimide/silica hybrid materials were prepared using the sol-gel process. The organosoluble polyimide was based on pyromellitic anhydride (PMDA) and 4,4Ј-diamino-3,3Ј-dimethyldiphenylmethane (MMDA). The silica particle size in the hybrid is increased from 100 -200 nm for the hybrid containing 5 wt % silica to 1-2 m for the hybrid containing 20 wt % silica. The strength and the toughness of the hybrids are improved simultaneously when the silica content is below 10 wt %. As the silica content is increased, the glass transition temperature (T g ) of the hybrids is increased slightly. The thermal stability of the hybrids is improved obviously and their coefficients of thermal expansion are reduced. The hybrids are soluble in strong polar aprotic organic solvents when the silica content is below 5 wt %.

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Association reactions of Cd+ with benzene and of Ag+ with acetone and several unsaturated hydrocarbons were observed in the Fourier-transform ion cyclotron resonance (FT-ICR) spectrometer. The reactions were presumed to occur by radiative association (RA) involving infrared photon emission, and the kinetics were analyzed to derive bond strengths for the ion−neutral complexes. To supply the structures, infrared frequencies, and infrared intensities required for this analysis, ab initio calculations at the Hartree−Fock (HF) and second-order Moeller−Plesset perturbation theory (MP2) levels were carried out for the reactants and the association complexes, and the results are reported. The RA kinetics analysis yielded values for the binding energies of 1.41 ± 0.2 eV for Cd+(benzene), 1.68 ± 0.2 eV for Ag+(benzene), 1.66 ± 0.2 eV for Ag+(acetone), 1.70 ± 0.2 eV for Ag+(isoprene), and 1.71 ± 0.2 eV for Ag+(2-pentene). The MP2-derived modeling gave higher (and more reliable) binding energies than the HF-derived modeling, but the HF-level modeling was found to provide estimates of useful precision, except for the Ag+(benzene) case. Binding energies were also estimated for the observed Ag+L2 complexes, and within experimental and modeling error the second ligand was found to bind with the same energy as the first. Clustering of six or more acetaldehydes with Ag+ was observed, but it was considered most likely that this reflected fast association with low-abundance polymeric impurities in the acetaldehyde sample.