Control of oxytetracycline-resistant American foulbrood with tylosin and its toxicity to honey bees (<i>Apis mellifera</i>)

Elzen, Patti J.; Westervelt, David; Causey, David; Rivera, Raúl; Baxter, James R.; Feldlaufer, Mark F.

doi:10.1080/00218839.2002.11101075

Cited by 40 publications

(19 citation statements)

References 3 publications

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“…Indeed, the accumulation of this antibiotic in honey has been determined in several studies [5][6][7]. However, tetracycline resistant strains have been identified in the USA, Canada and Argentina [8][9][10][11][12][13], and so other antibiotics, such as tylosin and lincomycin have also been proposed to control AFB [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Determination of tylosins A, B, C and D in bee larvae by liquid chromatography coupled to ion trap-tandem mass spectrometry

Bernal

Martín

Toribio

et al. 2011

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Determination of tylosins A, B, C and D in bee larvae by liquid chromatography coupled to ion trap-tandem mass spectrometry

Bernal

Martín

Toribio

et al. 2011

Journal of Chromatography B

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“…oxytetracycline) are used to suppress the clinical symptoms and, hence, the outbreak of AFB. The drawbacks of this treatment are that (i) antibiotics are not effective against spores and, therefore, only mask the disease, and that (ii) oxytetracycline-resistant P. larvae-strains have developed making the quest for new effective antibiotics already necessary (Miyagi et al, 2000;Mussen, 2000;Kochansky et al, 2001;Elzen et al, 2002;Wu et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Reclassification, genotypes and virulence ofPaenibacillus larvae, the etiological agent of American foulbrood in honeybees – a review

Ashiralieva

Genersch

2006

Apidologie

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-American foulbrood, a worldwide bacterial disease of honeybee brood caused by the grampositive bacterium Paenibacillus larvae, is one of the most serious bee diseases. This review will focus on recent achievements in the study of Paenibacillus larvae brought about by molecular methods introduced into the field over the last fifteen years. One topic will be the classification of the etiological agent, which has changed several times since the first description in 1906 and was most recently modified again. Different genetic and biochemical methods for subtyping Paenibacillus larvae, the analysis of differences in virulence and the implications of these differences will also be covered.American foulbrood / Paenibacillus larvae / taxonomy / genotyping / virulence Abbreviations: AFB (American Foulbrood), P. l. larvae (Paenibacillus larvae subsp. larvae), P. l. pulvifaciens (Paenibacillus larvae subsp. pulvifaciens), P. larvae (Paenibacillus larvae), CFU (colony forming units), LC 50 (lethal concentration killing 50% of the larvae).

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“…Among them, tylosin appeared as an attractive alternative exhibiting both a bactericidal effect and the best in vitro inhibition of P. larvae in terms of the MIC, MBC, and MBC/MIC values (Peng et al, 1996;Alippi et al, 2005;Reynaldi et al, 2010b). Furthermore, the field efficacy of tylosin had already been demonstrated by several authors (Elzen et al, 2002;Alippi et al, 2005;Pettis & Feldlaufer, 2005). However, the consumption of tylosin was a trouble, for this reason, Peng et al (1996) recommended the use of cherry jelly as an attractant to improve the palatability of tylosin treatment.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of kinetic behaviour of two preparations of tylosin administered in beehives for American foulbrood control

Reynaldi¹,

Albo²,

Avellaneda³

et al. 2017

BJVM

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We compared the kinetic behaviour of tylosin administered to beehives by dusting or paper-pack placement through three treatment protocols (D, PP, CONTROL). D (dusting): tylosin, divided in four portions, was sprinkled over the ends of the hives' top bars weekly for four weeks (n=3); PP (paper-pack placement): tylosin in paper packs was administered at two-week intervals (n=3); CONTROL (control): the hives were left untreated (n=3). In every inspection, from each of the nine hives, fifty young (2-day-old) larvae were sampled for drug analysis. The concentration of tylosin in the young larvae was determined by a microbiological assay with Geobacillus stearothermophilus ATCC 12980 as test organism. The (mean±SD) maximum concentration (C max ) for D was 136.0±194.0 and for PP -144.0±187.4 µg/mL; the time to reach C max (t max ) was 1.5±0.9 h for D and 1.8 ± 1.8 h for PP. The area under the tylosin behaviour kinetics curve between 0-1392 h with D was 308.7±185.2 and with PP: 326.4±141.0 µg/h/mL, indicating no statistical difference between the treatments (P>0.05). The shorter duration of paper-pack-administered tylosin observed in the larvae implied a lower risk of antibiotic residues in the resulting honey.

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Control of oxytetracycline-resistant American foulbrood with tylosin and its toxicity to honey bees (Apis mellifera)

Cited by 40 publications

References 3 publications

Determination of tylosins A, B, C and D in bee larvae by liquid chromatography coupled to ion trap-tandem mass spectrometry

Determination of tylosins A, B, C and D in bee larvae by liquid chromatography coupled to ion trap-tandem mass spectrometry

Reclassification, genotypes and virulence ofPaenibacillus larvae, the etiological agent of American foulbrood in honeybees – a review

Evaluation of kinetic behaviour of two preparations of tylosin administered in beehives for American foulbrood control

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