Contraceptive efficacy of tamoxifen in female hamsters

Majumdar, Neena; Datta, Jhuma

doi:10.1016/0010-7824(90)90130-n

Cited by 6 publications

(1 citation statement)

References 19 publications

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“…[17][18][19] Tamoxifen when used in Guinea pigs and hamsters was found to cause spontaneous miscarraige which led to several human studies. 20 Tamoxifen produced significant impairment of decidual development, making it useful in termination of pregnancy. 21 In Orlando women center it is noted that the combines use of Tamoxifen and Misoprostol is about 94% effective for termination of pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Outcome of Using Tamoxifen With Misoprostol in First Trimester Pregnancy Termination

Latif

Hira²

2020

Pak Postgrad Med J.

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Objective: To determine the outcome of using tamoxifen with misoprostol in first trimester pregnancy termination. Materials & Methods: This study was a case series and conducted at Department of Gynaecology & Obstetrics from 1st April ,2018 to 30th September at Nishtar hospital Multan,2018 over the 6 months period .163 patients, 18 to 40 years of age with fetal demise or missed abortion confirmed on ultrasonography in 1st trimester (<12 gestational weeks) of pregnancy were included in the study. All the enrolled patients received 20 mg tamoxifen orally for 4 days then it is followed by 800 mcg oral misoprostol for 1 or 2 days orally (maximum 80 mg) and the outcome (in terms of complete abortion) was assessed after 7 days. Results: Mean age in our study was 24.89 ± 5.23 years. Mean gestational age was 7.07 ± 3.67 weeks. Majority of patient i.e. 49.69% were nulliparous. Complete abortion after tamoxifen with misoprostol therapy was seen in 149 (91.41%) cases. Conclusion: This study concluded that tamoxifen with misoprostol in first trimester pregnancy termination is very effective and useful with 91.41% rate of complete abortion.

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