A medical method of early pregnancy termination using tamoxifen and misoprostol

Mishell, Daniel R.; Jain, John K.; Byrne, James D.; Lacarra, Maria

doi:10.1016/s0010-7824(98)00061-4

Cited by 32 publications

(5 citation statements)

References 20 publications

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“…It is not uncommon to identify particulate remnants of the tablets in the vagina at the time of repeated dosing, indicating that dissolution and absorption are variable and incomplete 13,15 . Though moistening the tablets with water or saline was used to increase the dissolution of the tablet in the termination of first trimester pregnancy, 16–19 randomized trials failed to show improved efficacy 20–22 . On the other hand, misoprostol tablets are known to liquefy better in acidic medium 23,24 .…”

Section: Introductionmentioning

confidence: 99%

Effect of vaginal pH on the efficacy of vaginal misoprostol for induction of midtrimester abortion

Abd-El-Maeboud

Ghazy

Nadeem

et al. 2007

J of Obstet and Gynaecol

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Section: Introductionmentioning

confidence: 99%

Effect of vaginal pH on the efficacy of vaginal misoprostol for induction of midtrimester abortion

Abd-El-Maeboud

Ghazy

Nadeem

et al. 2007

J of Obstet and Gynaecol

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“…[27][28][29] In our study, average number of days of bleeding PV was 14.03 ± 14.44. This is much higher than documented in other studies.…”

Section: Vidyasagar V Int J Reprod Contracept Obstet Gynecol 2015 Ocmentioning

confidence: 48%

Correlation between ultrasound and histopathological findings of products of uterine evacuation in cases admitted after medical abortion

Vidyasagar

2015

Int J Reprod Contracept Obstet Gynecol

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“…However, the use of the SERM TMX in female patients has also been associated with complications. For example, as early as 1998, Mishell et al (45) reported that TMX administration followed by intravaginal misoprostol could be used to induce abortion in pregnancies as late as 56 days of gestational age. SERMs, including clomiphene citrate and TMX, have also been used as the first-line treatment of choice for anovulation (46).…”

Section: The Potential Strategies For Targeting Estrogen Signaling In Mmtmentioning

confidence: 99%

Add-On Selective Estrogen Receptor Modulators for Methadone Maintenance Treatment

et al. 2021

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Methadone maintenance treatment (MMT) remains the cornerstone for the management of opiate abuse. However, MMT can be associated with complex factors, including complications during the tolerance phase, the inability of some patients to maintain treatment effects during the tapering or abstinence phases, and the development of methadone dependence. Previous studies have revealed a sex disparity in MMT efficacy, showing that women undergoing MMT experiencing an increase in psychological symptoms compared with men and suggesting a link between disparate responses and the effects of estrogen signaling on methadone metabolism. More specifically, estradiol levels are positively associated with MMT dosing, and the expression of a single-nucleotide polymorphism (SNP) associated with estrogen receptor (ER) regulation is also associated with MMT dosing. In addition to performing mechanistic dissections of estrogen signaling in the presence of methadone, past studies have also proposed the targeting of estrogen signaling during MMT. The present report provides an overview of the relevant literature regarding sex effects, including differences in sex hormones and their potential impacts on MMT regimens. Moreover, this article provides a pharmacological perspective on the targeting of estrogen signals through the use of selective ER modulators (SERMs) during MMT. Preliminary preclinical experiments were also performed to evaluate the potential effects of targeting estrogen signaling with tamoxifen on methadone metabolism.

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A medical method of early pregnancy termination using tamoxifen and misoprostol

Cited by 32 publications

References 20 publications

Effect of vaginal pH on the efficacy of vaginal misoprostol for induction of midtrimester abortion

Effect of vaginal pH on the efficacy of vaginal misoprostol for induction of midtrimester abortion

Correlation between ultrasound and histopathological findings of products of uterine evacuation in cases admitted after medical abortion

Add-On Selective Estrogen Receptor Modulators for Methadone Maintenance Treatment

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