Outcome of Using Tamoxifen With Misoprostol in First Trimester Pregnancy Termination

Abstract

Objective:
 To determine the outcome of using tamoxifen with misoprostol in first trimester pregnancy termination.
 Materials & Methods: 
 This study was a case series and conducted at Department of Gynaecology & Obstetrics from 1st April ,2018 to 30th September at Nishtar hospital Multan,2018 over the 6 months period .163 patients, 18 to 40 years of age with fetal demise or missed abortion confirmed on ultrasonography in 1st trimester (<12 gestational weeks) of pregnancy were included in the study. All the enrolled patients received 20 mg tamoxifen orally for 4 days then it is followed by 800 mcg oral misoprostol for 1 or 2 days orally (maximum 80 mg) and the outcome (in terms of complete abortion) was assessed after 7 days.
 Results: 
 Mean age in our study was 24.89 ± 5.23 years. Mean gestational age was 7.07 ± 3.67 weeks. Majority of patient i.e. 49.69% were nulliparous. Complete abortion after tamoxifen with misoprostol therapy was seen in 149 (91.41%) cases.
 Conclusion: 
 This study concluded that tamoxifen with misoprostol in first trimester pregnancy termination is very effective and useful with 91.41% rate of complete abortion.