Constituents from the Stems of Hibiscus taiwanensis

Wu, Pei Lin; Wu, Tian Shung; He, Cai Xia; Su, Chia‐Hao; Lee, Kuo Hsiung̀

doi:10.1248/cpb.53.56

Cited by 40 publications

(31 citation statements)

References 30 publications

(21 reference statements)

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“…A phenolic compound, protocatechuic acid, isolated from the dried flower buds of Hibiscus sabdariffa, at the concentration of 0.2 to 2mM, exhibited an antiproliferative effect on HL-60 cells by inducing apoptosis, which was associated with the phosphorylation and degradation of RB and suppression of Bcl-2 protein . Myriceric acid (5) and uncarinic acid A (6), isolated from the stems of Hibiscus taiwanensis Hu., have shown cytotoxic activity against human lung carcinoma and breast carcinoma (Wu et al, 2005). Delpenidin 3-sambubioside (7), an anthocyanin isolated from the dried calyx of Hibiscus sabdariffa, was shown to induce dose-dependent apoptosis in human leukemia cells (HL-60) through a reactive oxygen species (ROS)-mediated mitochondrial dysfunction pathway (Hou et al, 2005).…”

Section: Antitumormentioning

confidence: 99%

“…Raw polysaccharides and three acidic subfractions isolated from the flowers of Hibiscus sabdariffa were shown to cause a strong induction of proliferation of human keratinocytes (Ha CaT), up to 40% (Brunold et al, 2004). Mansonone H (35) and uncarinic acid (6), isolated from the stems of Hibiscus taiwanensis, were shown to inhibit HIV replication in H9 lymphocytic cells (Wu et al, 2005).…”

Section: Miscellaneousmentioning

confidence: 99%

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Biologically Active Compounds from the GenusHibiscus.

Vasudeva

Sharma

2008

Pharmaceutical Biology

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Since ancient times, Hibiscus species (Malvaceae) have been used as a folk remedy for the treatment of skin diseases, as an antifertility agent, antiseptic, and carminative. Some compounds isolated from the species, such as flavonoids, phenolic acids, and polysaccharides, are considered responsible for these activities. This review aims to summarize the worldwide reported biological activities and phytoconstituents associated with this genus for the past 40 years.

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Section: Antitumormentioning

confidence: 99%

Section: Miscellaneousmentioning

confidence: 99%

Biologically Active Compounds from the GenusHibiscus.

Vasudeva

Sharma

2008

Pharmaceutical Biology

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“…20) The compound has been reported to show bioactivities such as antimicrobial and anti-HIV activities. [21][22][23][24] From the preliminary tests of FA, R-(Ϫ)-mellein, clerodermic acid, and salicifoline chloride, isolated from E. membranifolium, FA showed the most potent inhibitory effect against melanogenesis. Further studies of FA were carried out to define the mechanism of its inhibitory activity on melanogenesis in mouse B16 melanoma cells.…”

Section: Resultsmentioning

confidence: 99%

N-trans-Feruloyltyramine as a Melanin Biosynthesis Inhibitor

Efdi

Ohguchi

Akao

et al. 2007

Biological & Pharmaceutical Bulletin

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In this study, we examined the effect of N-trans-feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibitor of melanogenesis. Moreover, treatment of B16 melanoma cells with FA was found to cause marked decreases in the expression levels of tyrosinase. FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.

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“…All of these data were consistent with erythro-carolignan E (Figure 1) in which this compound has been previously reported by Rudiyansyah etal., (2010), Huang et al, (2012), Paula et al,(1995) and by Wu et al, (2005). The relative configuration of 1 was elucidated by a triplet signal for H-7' with a coupling constant of 3.3 Hz (in CDCl 3 ) which is diagnostic of an erythro diastereomer (Braga et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

Study of Conformational Preferences of Erythro-Carolignan E Assessed by the Coupling Between H7'-H8' in Different NMR Solvents

2016

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Erythro-carolignan E (1) has been obtained from the ethanol extract of the wood bark of Durio affinis Becc. This research was conducted in order to prove that conformational preferences of compound 1 were solvent dependent. On the basis of 1 H-NMR data, the relative configuration of compound 1 was characterized by a coupling constant ( 3 J HH ) value of 3.3 Hz at H-7' in CDCl 3 . The coupling constant ( 3 J HH ) values of H-7' in compound 1 has changed to 4.1 Hz and 5.3 Hz in pyridine-d 5 and acetonitrile-d 3 respectively. As a result, the conformation of compound 1 at C7'-C8' has changed in different NMR solvents. In conclusion, structure of erythro-carolignan E that contains a dihydroxy group at C7'-C8' is able to change in different NMR solvent.

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Constituents from the Stems of Hibiscus taiwanensis

Cited by 40 publications

References 30 publications

Biologically Active Compounds from the GenusHibiscus.

Biologically Active Compounds from the GenusHibiscus.

N-trans-Feruloyltyramine as a Melanin Biosynthesis Inhibitor

Study of Conformational Preferences of Erythro-Carolignan E Assessed by the Coupling Between H7'-H8' in Different NMR Solvents

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