Biologically Active Compounds from the GenusHibiscus.

Abstract

Since ancient times, Hibiscus species (Malvaceae) have been used as a folk remedy for the treatment of skin diseases, as an antifertility agent, antiseptic, and carminative. Some compounds isolated from the species, such as flavonoids, phenolic acids, and polysaccharides, are considered responsible for these activities. This review aims to summarize the worldwide reported biological activities and phytoconstituents associated with this genus for the past 40 years.

Neuroprotective effect of the methanolic extract of Hibiscus asper leaves in 6-hydroxydopamine-lesioned rat model of Parkinson's disease

“…(Malvaceae) is an important medicinal plant widely distributed throughout tropical Africa and in Madagascar. This species belongs to the genus Hibiscus represented by 250 species and characterizes by the presence of biologically active compounds like flavonoids, phenolic acids, and polysaccharides (Vasudeva and Sharma, 2008). In the western region of the Africa, this plant is widely used by the traditional practitioners for the treatment of inflammation, anemia, jaundice, leucorrhoea, poison antidote, depression and dysmenorrhea (Schippers and Bosch, 2004).…”

Methanolic extract of Hibiscus asper leaves improves spatial memory deficits in the 6-hydroxydopamine-lesion rodent model of Parkinson's disease

“…(Malvaceae) is an important medicinal plant widely distributed throughout tropical Africa and in Madagascar. This species belongs to the genus Hibiscus represented by 250 species and characterizes by the presence of biological active compounds like flavonoids, phenolic acids, and polysaccharides (Vasudeva and Sharma, 2008). In the western region of the Africa, this plant is widely used by the traditional practitioners of the treatment of inflammation, anemia, jaundice, leucorrhoea, poison antidote, depression and dysmenorrhea (Schippers and Bosch, 2004).…”

On-line (HPLC-NMR) and Off-line Phytochemical Profiling of the Australian Plant, Lasiopetalum macrophyllum

“…Malvaceae is comprised of many well known genera including Gossypium (cotton) and Hibiscus (ornamental), and many of these genera are known to contain biologically active constituents [17,18]. The Malvaceae has afforded many classes of secondary metabolites, including terpenoids (1-3) [19], alkaloids (4)(5) [20], steroids (6-7) [21], naphthalenes (8)(9) [17], and flavonoids (10)(11)(12)(13)(14)(15)(16) (Figure 1) [17,[21][22][23][24][25]. The genus Lasiopetalum, belonging to this family, has not been studied widely in terms of its secondary metabolites, with only fatty acid analyses of seed oils being reported to date [26,27].…”

“…For the HPLC-NMR chemical profiling, the plant material was extracted and subjected to the fractionation methodology as described in the 'Preparation of the extract of L. macrophyllum for on-flow and stop-flow HPLC-NMR analysis' section. An off-line HPLC method for the separation of the methanol extract was developed prior to On the basis of this NMR data and the fact that this family is known to produce flavonoid glycosides [17,21,23,28,29], this compound was suggested to be trans-tiliroside (16), as illustrated in the 2D HPLC-NMR contour plot and in the extracted WET-1D 1 H NMR spectrum ( Figure 2). Given the relatively poor signal-to-noise obtained in the on-flow HPLC-NMR analysis, together with the fact that the other components observed in the HPLC chromatogram could not be detected, it was necessary to carry out stop-flow HPLC-NMR analyses.…”

“…The methanol extract was re-injected and stop-flow HPLC-NMR analysis employed, enabling the HPLC separation to be stopped and the chromatographic peak of interest to be trapped within the NMR flow-cell. This led to extended acquisition times for the WET-1D 1 H NMR experiments (typically 20 mins -16 h) and resulted in a significantly improved signal-to-noise WET-1D 1 H NMR spectrum for the major flavonoid glycoside trans-tiliroside (16), as well as allowing for the detection of two additional flavonoid glycosides suggested to be cis-tiliroside (17) and 4′-Omethoxy-cis-tiliroside (18), as illustrated in Figure 2. All WET-1D 1 H NMR spectra exhibited resonances consistent with the presence of olefinic and aromatic methines, along with signals associated with a sugar moiety.…”