Conductive poly(2-ethylaniline) dextran-based hydrogels for electrically controlled diclofenac release

Paradee, Nophawan; Thanokiang, Jirawat; Sirivat, Anuvat

doi:10.1016/j.msec.2020.111346

Cited by 19 publications

(11 citation statements)

References 36 publications

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“…The diffusion coefficient of the insulin increases from 4.99 × 1 0 −10 cm 2 /s to 5.93 × 1 0 −10 cm 2 /s as shown in Table 2 . The time to equilibrium decreases from 9 h to 3 h. Under electric field, it provides 2 main mechanisms: 1) the electro-repulsive force between the negative charge of insulin (pI of insulin 5.4) (Nadendla & Friedman, 2017 ; Zhang et al., 2019 ) and the negatively charged electrode (Paradee et al., 2021 ); and 2) the electro-repulsive force between negative charge of SF hydrogels and the negatively charged electrode inducing matrix expansion known as the ‘silk-expansion effect’ (Mongkolkitikul et al., 2017 ).…”

Section: Resultsmentioning

confidence: 99%

“…This was due to a longer time required to generate aqueous pathways or pores in the fluid lipid bilayer membrane during the ‘the pore formation period’ (Ruangmak et al., 2021 ). At a higher electric field, the amount of insulin released-permeation increases due to the ‘electro-repulsive force’ between the anionic drug (pI of insulin 5.4) (Nadendla & Friedman, 2017 ; Zhang et al., 2019 ) and the negatively charge electrode (Paradee et al., 2021 ), and the ‘silk-expansion effect’ (Mongkolkitikul et al., 2017 ).…”

Section: Resultsmentioning

confidence: 99%

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Enhanced transdermal insulin basal release from silk fibroin (SF) hydrogels via iontophoresis

2022

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Insulin is the peptide hormone used to treat the diabetes patient. The hormone is normally taken by injection. The transdermal drug delivery system (TDDS) is an alternative route. The silk fibroin (SF) hydrogels were fabricated via solution casting as the insulin matrix. The release and release-permeation experiments of the insulin loaded SF hydrogels were carried out using a modified Franz-diffusion cell at 37 °C for 36 h, under the effects of SF concentrations, pH, and electric field. The release-permeation mechanism through the pig skin was from the Case-II transport with the constant release rate. The diffusion coefficient (D) increased with decreasing SF concentration due to a larger mesh size, and with increasing electric field due to the electroreplusive forces between the insulin and the SF hydrogels against the negatively-charged electrode, and the induced SF hydrogel expansion. The rate and amount of insulin release-permeation became relatively lower as it required a longer time to generate aqueous pathways through the pig skin. The present SF hydrogels are demonstrated here deliver insulin with the required constant release rate, and the suitable amount within a prescribed duration.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Enhanced transdermal insulin basal release from silk fibroin (SF) hydrogels via iontophoresis

2022

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“…The results showed that the zeta potential of magnetosomes (À25.85 mV) was far less than that of BMDCs (À34.42 mV), suggesting that DOX might be coupled with the surface of magnetosomes. The negative charge of magnetosomes might be due to the presence of negatively charged groups on their surface, such as the carboxylate group and hydroxyl group, 59 which was characterized by FT-IR in the present work. The phenomenon in the obvious variation of zeta potential after coupling might be ascribed to the chemical reaction between the amino groups on the surface of magnetosomes and carbonyl groups in genipin, resulting in the reduction of positive charge.…”

Section: Discussionmentioning

confidence: 85%

Preparation, characterization, and in vitro release kinetics of doxorubicin-loaded magnetosomes

et al. 2021

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The doxorubicin (DOX) was successfully coupled to the magnetosomes from Acidithiobacillus ferrooxidans ( At. ferrooxidans) by genipin bridging. The parameters (magnetosome concentration, DOX concentration, genipin concentration-, and cross-link time) expected for temperature significantly influenced the coupling rate. Bacterial magnetosome-doxorubicin complexes (BMDCs) were characterized by transmission electron microscope (TEM), particle size analyzer and Fourier transform infrared spectroscopy. Results indicated that BMDCs exhibited a mean particle size of 83.98 mm and displayed a negative charge. The chemical reaction occurring between CO and NH group and the physical adsorption predominated by electrostatic interaction were found to involve in coupling. BMDCs can release 40% of DOX in simulated gastrointestinal conditions within 38 h. Kinetic models including Higuchi, Korsmeyer–Peppas, Zero order, First order, Hixon-Crowell, Baker-Lonsdale, and Weibull and Gompertz were utilized to explore the release mechanism of DOX from BMDCs. All models were found to fit well (r2 ≥ 0.8144) with the release data and the Gompertz was the best fit model (r2 = 0.9742), implying that the complex mechanisms involving Fickian and Gompertz diffusion contributed to the release. These findings suggested that magnetosomes from At. ferrooxidans have great potential applications in biomedical and clinical fields as the carrier of target drug delivery systems in the future.

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“…The application of an electrical stimulus results in drug release by Fickian diffusion combined with matrix swelling. [ 39 ]…”

Section: Externally Regulated Pulsatile Release Systemsmentioning

confidence: 99%

Recent advances in remotely controlled pulsatile drug delivery systems

Khalifa

Zyad

Mohammed

et al. 2022

J Adv Pharm Technol Res

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Pharmaceutical technology is drastically developing to enhance the efficacy and safety of drug therapy. Pulsatile delivery systems, in turn, gained attraction for their ability to deliver the right drug amount to the right body site, at the right time which is advantageous over conventional dosage forms. Their use is associated with increased patient compliance and allows on-demand drug delivery as well as customizable therapy. Recent technologies have been implemented to further develop pulsatile delivery systems for more precise determination of the dosage timing and duration as well as the location of drug release. Great interests are directed towards externally regulated pulsatile release systems which will be the focus of this review. The recent advances will be highlighted in remotely controlled delivery systems. This includes electro responsive, light-responsive, ultrasound responsive, and magnetically induced pulsatile systems as well as wirelessly controlled implantable systems. The current status of these technologies will be discussed as well as the recent investigations and future applications.

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Conductive poly(2-ethylaniline) dextran-based hydrogels for electrically controlled diclofenac release

Cited by 19 publications

References 36 publications

Enhanced transdermal insulin basal release from silk fibroin (SF) hydrogels via iontophoresis

Enhanced transdermal insulin basal release from silk fibroin (SF) hydrogels via iontophoresis

Preparation, characterization, and in vitro release kinetics of doxorubicin-loaded magnetosomes

Recent advances in remotely controlled pulsatile drug delivery systems

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