Recent advances in remotely controlled pulsatile drug delivery systems

Abstract

Pharmaceutical technology is drastically developing to enhance the efficacy and safety of drug therapy. Pulsatile delivery systems, in turn, gained attraction for their ability to deliver the right drug amount to the right body site, at the right time which is advantageous over conventional dosage forms. Their use is associated with increased patient compliance and allows on-demand drug delivery as well as customizable therapy. Recent technologies have been implemented to further develop pulsatile delivery systems for more precise determination of the dosage timing and duration as well as the location of drug release. Great interests are directed towards externally regulated pulsatile release systems which will be the focus of this review. The recent advances will be highlighted in remotely controlled delivery systems. This includes electro responsive, light-responsive, ultrasound responsive, and magnetically induced pulsatile systems as well as wirelessly controlled implantable systems. The current status of these technologies will be discussed as well as the recent investigations and future applications.

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

“…54,55 PDDS are available based on time-controlled (erodible coating: bulk, surface, rupturable, and capsule shaped), stimuli-sensitive (thermoresponsive and chemical), and externally regulated (electro-responsive, ultrasonically stimulation, and magnetic induction) approaches. 53,55 Technologies such as 3D printing, Diffucap, Pulsincap, CODAS, IPDAS, OROS, GEOCLOCK, Opana ER, Unipyl, and Ritalina are currently well-known marketed PDDS. Pulsatile release of drugs entails a cyclic pattern of drug liberation occurring at different time intervals.…”

“…Pulsatile drug delivery systems (PDDS)-based tablets have additional benefits over conventional tablet (dosage) forms . The PDDS-based tablets maintain constant drug concentration(s) in the blood and tissues at the right time and amount, and site of action, thereby enhancing the therapeutic efficacy and patient compliance. , PDDS are available based on time-controlled (erodible coating: bulk, surface, rupturable, and capsule shaped), stimuli-sensitive (thermoresponsive and chemical), and externally regulated (electro-responsive, ultrasonically stimulation, and magnetic induction) approaches. , Technologies such as 3D printing, Diffucap, Pulsincap, CODAS, IPDAS, OROS, GEOCLOCK, Opana ER, Unipyl, and Ritalina are currently well-known marketed PDDS. Pulsatile release of drugs entails a cyclic pattern of drug liberation occurring at different time intervals.…”

An Overview of the Circadian Clock in the Frame of Chronotherapy: From Bench to Bedside

“…Porous beads have thus been investigated for their potential to offer a pulsatile drug delivery [ 122 ], still to be adapted for long periods. About circadian interventions, the development of delivery systems that can be implanted and remotely controlled [ 123 ] should be of great interest for daily administrations at specific times.…”

Drug delivery via a 3D electro-swellable conjugated polymer hydrogel

“…Moreover, many diseases affecting high percentages of population require a specific temporal pattern of drug dosing, such as hormonal regulation, pain relief control or chemotherapy (Table ST1, ESI †). However, conventional system do not provide the required specific temporal pattern for the drug dosing, [2][3][4] All these reasons motivate the need for local drug delivery, in a temporally and spatially controlled manner.…”