Drug delivery <i>via</i> a 3D electro-swellable conjugated polymer hydrogel

Abdel Aziz, Ilaria; Gladisch, Johannes; Griggs, Sophie; Moser, Maximilian; Biesmans, Hanne; Beloqui, Ana; McCulloch, Iain; Berggren, Magnus; Stavrinidou, Eleni

doi:10.1039/d3tb02592f

J. Mater. Chem. B

2024

DOI: 10.1039/d3tb02592f

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Drug delivery via a 3D electro-swellable conjugated polymer hydrogel

Ilaria Abdel Aziz,

Johannes Gladisch,

Sophie Griggs

et al.

Abstract: Spatiotemporal controlled drug delivery minimizes side-effects and enable therapies that require specific dosing patterns. Conjugated polymers (CP) can be used for electrically controlled drug delivery; however so far, most demonstrations...

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Conducting Polymers for In Situ Drug Release Triggered via Electrical Stimulus

Pérez-Nava,

González-Campos,

Frontana-Uribe

2024

ACS Appl. Polym. Mater.

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Conducting polymers (CPs) are a unique type of polymer that exhibit metal-like features. Their ability to undergo reversible redox conversion, in addition to their optical and electronic properties, have enhanced the use of CPs in the development of advanced materials for technological applications, mainly focused on the energy field. However, during the last 15 years, increasing interest has been focused on biomedical and pharmaceutical applications of CPs. The development of CPs-based biocomposites for drug release takes advantage of the reversible redox behavior of CPs, allowing an accurate control of therapeutic agents and other bioactive molecule release profiles, triggered by an external stimulus. This Review discusses the development of drug delivery systems based on CPs. Encompassing intrinsic features, such as physicochemical aspects, electrical ability, and conducting mechanism involved in the release of therapeutic agents driven by electrochemical stimuli. A detailed description of the electrochemical drug-loading, methods of fabrication, and characterization of innovative CPs-based drug delivery platforms is provided. A comparative analysis of polymerization methods is presented to guide researchers in the method selection. Finally, application of CPs on drug release, and cell response, is discussed in terms of their intrinsic properties, which enhance their pharmaceutical applications.

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Conducting Polymers for In Situ Drug Release Triggered via Electrical Stimulus

Pérez-Nava,

González-Campos,

Frontana-Uribe

2024

ACS Appl. Polym. Mater.

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show abstract

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Drug delivery via a 3D electro-swellable conjugated polymer hydrogel

Abstract: Spatiotemporal controlled drug delivery minimizes side-effects and enable therapies that require specific dosing patterns. Conjugated polymers (CP) can be used for electrically controlled drug delivery; however so far, most demonstrations...

Cited by 1 publication

References 50 publications

Conducting Polymers for In Situ Drug Release Triggered via Electrical Stimulus

Conducting Polymers for In Situ Drug Release Triggered via Electrical Stimulus

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