Complete resolution of laryngeal amyloidosis with radiation treatment

Abstract

Recent pathologic studies suggest that localized amyloidosis of the larynx is caused by a localized, nonmalignant plasma cell disorder. Because full resection is difficult, we recommend a combination of surgery and radiation therapy to cure this disease.

Intensity-modulated radiotherapy for localized nasopharyngeal amyloidosis

“…Then, a second treatment with an additional 20 Gy resulted in an outcome qualified as a "partial success" [30]. Correspondingly, Geoffrey et al [31] concluded that patients diagnosed with laryngeal amyloidosis should be treated with a total dose of 45 Gy. Moreover, Kitaevich et al [32] reported the case of a patient with laryngeal amyloidosis who initially received 44.62 Gy, but experienced disease relapse at 2.25 years after therapy.…”

Tracheobronchial amyloidosis managed with multimodality therapies

“…Radiation esophagitis was the most common complication [NebenWittich et al 2007;Truong et al 2011]. Treatment with low dose radiation therapy has been reported with similar efficacy by others in the literature [Monroe et al 2004;Neben-Wittich et al 2007;Neuner et al 2010].…”

Primary Laryngeal Amyloidosis: A Case Report

“…The cause for localized laryngeal amyloidosis is unknown, it is hypothesized that it may be because of an inflammatory cell reaction of plasma cells to the antigens present [6] or the inability of the body to clear the monoclonal light chains produced by the mucosa associated lymphoid tissue [4]. The amyloid deposition leads to an alteration of the structure and hampers the function of the organ [7].…”