Compatibility studies of nateglinide with excipients in immediate release tablets

Pani, Nihar Ranjan; Nath, Lila Kanta; Acharya, S.

doi:10.2478/v10007-011-0016-4

Cited by 44 publications

(18 citation statements)

References 12 publications

(10 reference statements)

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“…Differential scanning calorimetry (DSC) can successfully evaluate the drug-excipient compatibility and consequently offer valuable information about the properties of materials such as stability, polymorphism, kinetic analysis and phase transitions [24][25][26].…”

Section: Dscmentioning

confidence: 99%

DSC kinetic study of the incompatibility of doxepin with dextrose

Ghaderi

Nemati

Siahi-Shadbad

et al. 2015

J Therm Anal Calorim

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In the present paper, the physicochemical incompatibility of doxepin with dextrose was evaluated in solid-state mixtures. The compatibility was evaluated using different physicochemical methods such as differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy and mass spectrometry. Non-isothermally stressed physical mixtures were used to study the solidstate kinetic parameters. Different thermal models such as Friedman, Flynn-Wall-Ozawa and Kissinger-AkahiraSunose were used for the characterization of the drugexcipient mixtures. Overall, the incompatibility of doxepin as a tertiary amine with dextrose as a reducing carbohydrate was successfully assessed. DSC-based kinetic analysis is a simple and fast method in evaluation of different drug-excipient mixtures incompatibility. Finally, it can be recommended to exclude dextrose from doxepin pharmaceutical formulations and also to apply the easy and versatile DSC method in kinetic study of drug-excipient incompatibility.

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Section: Dscmentioning

confidence: 99%

DSC kinetic study of the incompatibility of doxepin with dextrose

Ghaderi

Nemati

Siahi-Shadbad

et al. 2015

J Therm Anal Calorim

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“…The thermogram of formulation F6 shows the RNT peak at 142.90 °C, which demonstrates the presence of form 2. Moreover, reduction of the RNT melting point in formulation F6 might be due to its mixing with ALG, which lowered the purity of each component (29). Melting peak of ALG (119.27 °C) was not detected in F6, which might suggest that ALG had dehydrated during the spray drying process (30).…”

Section: Dsc Studiesmentioning

confidence: 97%

Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine

2015

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Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidineThe present study is aimed at formulation of alginate (ALG) microspheres with ranitidine (RNT) by the spray drying method. Obtained microspheres were characterized for particle size, surface morphology, entrapment efficiency, drug loading, in vitro drug release and zeta potential. Mucoadhesive properties were examined by a texture analyser and three types of adhesive layers -gelatine discs, mucin gel and porcine stomach mucosa. Microspheres showed a smooth surface with narrow particle size distribution and RNT loading of up to 70.9 %. All formulations possessed mucoadhesive properties and exhibited prolonged drug release according to the first-order kinetics. DSC reports showed that there was no interaction between RNT and ALG. Designed microspheres can be considered potential carriers of ranitidine with prolonged residence time in the stomach.

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“…[34,35,41] The data analyzed of K, n, and r 2 of this study baclofen release from the transdermal films are shown in Table 4. The values of n were in the range of 0.45 and 0.89 for all formulations except for F8, indicating anomalous (non-Fickian) release kinetics.…”

Section: Kinetic Analysis Of Baclofen Released From Different Patchesmentioning

confidence: 99%

“…To determine the release mechanism of baclofen from the formulated transdermal patches, the data for the first 70% of the released drug were plotted using Peppas and Korsmeyer equation (3): [16,34,35] …”

Section: Study Of Release Mechanismsmentioning

confidence: 99%

Untitled

Ali

2017

AJP

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Aim: The aim of this study is to formulate and evaluate of baclofen transdermal patches using different polymers, penetration enhancers, and plasticizers. A drug with different film forming polymers was subjected to compatibility study. In addition, in-vitro permeation across animal skin for the best formulation was investigated. Materials and Methods: After studying the incompatibility of baclofen and other polymers used, the pure drug baclofen was formulated as transdermal patches composed of different polymers by solvent evaporation method and the formulations were 16. Then, the physicochemical properties of formulated patches were evaluated to determine the best optimum formula to be examined in-vitro release. Results and Discussion: The drug excipient compatibility study revealed no interaction between baclofen and polymers used. All the physicochemical studies of formulated patches were satisfactory except the formulation. The best-chosen formula was F13 that composed of polyvinyl alcohol as film-forming polymer and Carbopol 940 as bioadhesive polymer with propylene glycol as plasticizer and dimethyl sulfoxide as penetration enhancer. Conclusion: Study indicates that baclofen can be formulated as transdermal patches of acceptable appearance and suitable drug release through 24 h.

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Compatibility studies of nateglinide with excipients in immediate release tablets

Cited by 44 publications

References 12 publications

DSC kinetic study of the incompatibility of doxepin with dextrose

DSC kinetic study of the incompatibility of doxepin with dextrose

Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine

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