DSC kinetic study of the incompatibility of doxepin with dextrose

Abstract

In the present paper, the physicochemical incompatibility of doxepin with dextrose was evaluated in solid-state mixtures. The compatibility was evaluated using different physicochemical methods such as differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy and mass spectrometry. Non-isothermally stressed physical mixtures were used to study the solidstate kinetic parameters. Different thermal models such as Friedman, Flynn-Wall-Ozawa and Kissinger-AkahiraSunose were used for the characterization of the drugexcipient mixtures. Overall, the incompatibility of doxepin as a tertiary amine with dextrose as a reducing carbohydrate was successfully assessed. DSC-based kinetic analysis is a simple and fast method in evaluation of different drug-excipient mixtures incompatibility. Finally, it can be recommended to exclude dextrose from doxepin pharmaceutical formulations and also to apply the easy and versatile DSC method in kinetic study of drug-excipient incompatibility.

Investigation of Possible Maillard Reaction Between Acyclovir and Dextrose upon Dilution Prior to Parenteral Administration

“…All the maillard reaction tracking was done qualitatively and the reason for this was because of the identity of the maillard product reported as an unstable intermediate agent resulting from condensation of ACV with DEX and, thus, cannot be synthesized as a pure material to be used for accurate qualitative calculations. Similar researches have reported the maillard reaction in a similar way (5,41) as well as we have done previously (9,13,28,29,31,42).…”

“…Thus, physicochemical evaluations have been performed on solid materials in a concentrated condition to force the chemical reaction to take place. DSC DSC has been widely used in monitoring the presence of incompatibility in pharmaceutical preparations (22)(23)(24)(25)(26)(27)(28)(29)(30)(31). Compatibility data should be interpreted carefully as lots of deviations from principal laws can be explained.…”

Evaluation the Effect of Amine Type on the Non-isothermally Derived Activation Energy for the Interaction of 3 Antidepressant Drugs with Lactose

“…8,11,12 While increasing heating rate DSC thermograms were shifted to higher temperature and this issue was used to calculation of kinetic parameters. 14,15 DSC thermograms of FLM-lactose, SER-lactose and DOX-lactose 1:1 binary mixtures at different heating rates are presented in Figure 3.…”

Analytical Investigation of the Possible Chemical Interaction of Methyldopa with Some Reducing Carbohydrates Used as Pharmaceutical Excipients

“…After incubation, the sample showed 1522 cm -1 absorption peak, but the absorption at 1610 cm -1 was eliminated 3-A-c, and new and strong absorptions in 1622 and 1719 cm -1 occurred, which may be to loss of type one amine as the result of conversion to type 2 and carboxylic acid functionality, respectively. 27-29 The shift observed for the absorption wave number of the carboxylic acid may be due to adjacent amine change and subsequent reduced bond electro negativity.…”