Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine

Szekalska, Marta; Amelian, Aleksandra; Winnicka, Katarzyna

doi:10.1515/acph-2015-0008

Cited by 24 publications

(14 citation statements)

References 24 publications

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“…Owing to mucoadhesive properties, ALG are regarded as proper polymer excipients to prepare buccal [97][98][99], nasal [100,101], ocular [102,103], and gastrointestinal dosage forms [104][105][106][107][108]. Recently, several studies have shown favourable mucoadhesiveness of ALG-based applications in contact with vaginal mucosa tissue [108,109].…”

Section: General Properties Of Algmentioning

confidence: 99%

Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications

Szekalska

Puciłowska

Szymańska

et al. 2016

International Journal of Polymer Science

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433

250

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Over the last decades, alginates, natural multifunctional polymers, have increasingly drawn attention as attractive compounds in the biomedical and pharmaceutical fields due to their unique physicochemical properties and versatile biological activities. The focus of the paper is to describe biological and pharmacological activity of alginates and to discuss the present use and future possibilities of alginates as a tool in drug formulation. The recent technological advancements with using alginates, issues related to alginates suitability as matrix for three-dimensional tissue cultures, adjuvants of antibiotics, and antiviral agents in cell transplantation in diabetes or neurodegenerative diseases treatment, and an update on the antimicrobial and antiviral therapy of the alginate based drugs are also highlighted.

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Section: General Properties Of Algmentioning

confidence: 99%

Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications

Szekalska

Puciłowska

Szymańska

et al. 2016

International Journal of Polymer Science

Self Cite

433

250

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“…peptides and proteins) (Coppi et al, 2002), A c c e p t e d M a n u s c r i p t small molecules (e.g. ranitidine) (Szekalska et al, 2015) and lipopolysaccharides (Jain et al, 2015).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Spray-dried alginate microparticles for potential intranasal delivery of ropinirole hydrochloride: development, characterization and histopathological evaluation

Hussein

Omer

Ismael

et al. 2019

Pharmaceutical Development and Technology

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Ropinirole hydrochloride (RH) is an anti-Parkinson drug with relativity low oral bioavailability owing to its extensive hepatic first pass metabolism. Spray-dried mucoadhesive alginate microspheres of RH were developed and characterized followed by histopathological evaluation using nasal tissue isolated from sheep. Spherical microparticles having high product yield (around 70%) were obtained when the inlet temperature of spray drying was 140°C. Fourier Transform Infrared (FTIR) studies revealed the compatibility of the drug with the polymer, and scanning electron microscopy (SEM) showed that drug-loaded microparticles were spherical, and the apparent surface roughness was inversely related to the ratio of polymer to drug. Furthermore, size of the spray-dried particles were in the range of 2.5-4.37 µm, depending on formulation. All formulations had high drug encapsulation efficiencies (101-106%). Drug loaded into the polymeric particles was in the amorphous state and drug molecules were molecularly dispersed in the polymeric matrix of the microparticles which were revealed by X-ray diffraction and differential scanning calorimetry (DSC), respectively. The in vitro drug release was influenced by polymer concentration. Histopathological study demonstrated that RH-loaded sodium alginate microparticles was safe to nasal epithelium. In conclusion, spray drying of RH using sodium alginate polymer has produced microparticles of suitable characteristics for potential intranasal administration.

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“…Mucoadhesive Microsphere of ALG have recently demostrated to be a unique "carrier system" for many pharmaceuticals preparation increasing oral iron bioavailability of many drugs such as metformin, amoxicillin, furosemide, ibuprofen, insulin, acyclovir, captopril, glipizide and dicumarol [9][10][11] resulting in a promising drug delivery system [12].…”

Section: Introductionmentioning

confidence: 99%

Iron deficiency anemia (ida) and iron deficiency (id): are alginates a good choise to improve oral iron bioavailability and safety?

Baldacci¹,

Gervasi²,

Bertini³

2018

J Transl Sci

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Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine

Cited by 24 publications

References 24 publications

Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications

Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications

Spray-dried alginate microparticles for potential intranasal delivery of ropinirole hydrochloride: development, characterization and histopathological evaluation

Iron deficiency anemia (ida) and iron deficiency (id): are alginates a good choise to improve oral iron bioavailability and safety?

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