Comparison of two different optical coherence tomography angiography devices in detecting healthy versus glaucomatous eyes – an observational cross-sectional study

Abstract

Background To understand the differences between two different optical coherence tomography angiography (OCTA) devices in detecting glaucomatous from healthy eyes by comparing their vascular parameters, diagnostic accuracy and test-retest reliability. Methods A cross-sectional observational study was performed on healthy and glaucoma subjects, on whom two sets of OCTA images of optic disc and macula were acquired using both AngioVue (Optovue, USA) and Swept Source (Topcon, Japan) OCTA devices during one visit. A novel in-house software was used to calculate the vessel densities. Diagnostic accuracy of the machines in differentiating healthy versus glaucomatous eyes was determined using area under the receiver operating characteristic curve (AUROC) and test-retest repeatability of the machines was also evaluated. Results A total of 80 healthy and 38 glaucomatous eyes were evaluated. Glaucomatous eyes had reduced mean vessel density compared to healthy controls in all segmented layers of the optic disc and macula using AngioVue (p ≤ 0.001). However, glaucomatous eyes had higher mean vessel density on optic disc scans using Swept Source, with lack of statistically significant difference between healthy and glaucomatous eyes. The AUROC showed better diagnostic accuracy of AngioVue (0.761–1.000) compared to Swept Source (0.113–0.644). The test-retest reliability indices were generally better using AngioVue than Swept Source. Conclusions AngioVue showed better diagnostic capability and test-retest reliability compared to Swept Source. Further studies need to be undertaken to evaluate if there is any significant difference between the various machines in diagnosing and monitoring glaucoma.

Beetroot juice: effects on blood pressure, intraocular pressure, and ocular vessel density in healthy adults

“…Optical coherence tomography angiography has been shown to be capable of reproducible and repeatable measurements of retinal vessel density in both healthy subjects and in ocular disease 22,23 .…”

Addressing inter-device variations in optical coherence tomography angiography: will image-to-image translation systems help?

“…First, although data from different OCTA devices are not directly interchangeable [ 3 , 5 – 7 , 36 ], this may not necessarily imply that the inter-domain variations are very large. Indeed, there may be many shared features among different OCTA domains, and as a downside, such overlapping features can interfere with competent learning of the model – because it tries to learn features that do not help transform one domain to another (see Fig.…”

A comparison of two optical coherence tomography angiography devices in healthy eyes

“…B-taraması konumlarının her biri, tekrarlı olarak 4 defa taranmaktadır. 4,6 AngioVue OKTA cihazı 840 nm dalga boylu bir ışık kaynağı ve 50 nm bant genişliği kullanarak saniyede 70.000 A-tarama hızına sahiptir. Her OKTA volümü bir sonraki örnekleme konumuna geçmeden önce her sabit konumda iki ardışık B-tarama ile 304x304 A-tarama içerir.…”

“…Her OKTA volümü bir sonraki örnekleme konumuna geçmeden önce her sabit konumda iki ardışık B-tarama ile 304x304 A-tarama içerir. 5,6 Yapılan görüntülemelerin sinyal gücü ve kalitesi 6/10'nın üzerinde olanlar değerlendirmeye alınmıştır. Yüzeyel…”