Comparison of triamcinolone acetonide mucoadhesive film with licorice mucoadhesive film on radiotherapy‐induced oral mucositis: A randomized double‐blinded clinical trial

Ghalayani, Parichehr; Emami, Hamid; Pakravan, Fahimeh; Isfahani, Mehdi Nasr

doi:10.1111/ajco.12295

Cited by 36 publications

(33 citation statements)

References 23 publications

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“…Triamcinolone is commonly used in clinical dentistry because of its analgesic effects on oral ulcers. It has a potent anti-inflammatory effect and is effective in reducing oral scores of mucositis and pain in patients undertaking radiotherapy 12 . But corticoids used in treatment of inflammatory conditions not only inhibit the symptoms of acute inflammation but also retard wound healing 1 , 12 .…”

Section: Introductionmentioning

confidence: 99%

TNF-alpha expression, evaluation of collagen, and TUNEL of Matricaria recutita L. extract and triamcinolone on oral ulcer in diabetic rats

et al. 2016

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Diabetes mellitus (DM) is a disease associated with delayed wound healing of oral ulcers by increased expression of proinflammatory cytokines and cellular apoptosis. Objective to evaluate the influence of Tumor Necrosis Factor alpha (TNF-α) and apoptosis in rats with DM treated with chamomile extract or triamcinolone.Material and Methods Wistar male rats (210.0±4.2 g) were divided into five groups: negative control group (NCG) without diabetes; positive control group (PCG) with DM (alloxan, 45 mg/kg); and groups treated with chamomile extract (normoglycemic= NCG group and diabetic= DCG group) and with triamcinolone (TG). Traumatic ulcers were performed on all animals that received topical triamcinolone, chamomile extract or saline 12/12 hours for ten days.Results On days five and ten the animals were euthanized and the ulcers were analyzed by light microscopy, TUNEL assay, and immunohistochemically (TNF-α). The NCG (p=0.0062), PCG (p=0.0285), NCG (p=0.0041), and DCG (p<0.0001) groups were completely healed on the 10th day, however, there was no healing on the TG (p=0.5127) group. The TNF-α expression showed a significant reduction from the 5th to the 10th day in NCG (p=0.0266) and DCG (p=0.0062). In connective tissue, the TUNEL assay showed a significant reduction in the number of positive cells in NCG (p=0.0273) and CNG (p=0.0469) and in the epithelium only in CDG (p=0.0320).Conclusions Chamomile extract can optimize the healing of traumatic oral ulcers in diabetic rats through the reduction of apoptosis in the epithelium and TNF-α expression.

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Section: Introductionmentioning

confidence: 99%

TNF-alpha expression, evaluation of collagen, and TUNEL of Matricaria recutita L. extract and triamcinolone on oral ulcer in diabetic rats

et al. 2016

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“…Sigara bırakımını takiben kullanılan meyan kökü içerikli çiğneme tütünü ve benzeri maddeler dişlerin kole bölgelerinde boyanmalara ve mukozada kalınlaşma ile gelişen hiperkeratozlara neden olabilmektedir. Diş hekimleri, yaptıkları ağız içi muayenelerde aşırı derecede lekeli diş, lekeli bir dil ve tütün kullanımına ait diğer orodental bulgularla birlikte hastada yüksek kan basıncı varlığında gelişen MK toksisitesine karşı dikkatli olmalıdır (42).…”

Section: Sonuçunclassified

Diş Hekimliğinde Tamamlayıcı Bitkisel Tedaviler

Ergün¹,

Şahin²,

Kara³

2019

Akd Med J

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Bu derlemenin amacı, diş hekimliği alanındaki bitkisel tedavilerin modern bilimin ışığında kullanılabilirliğini irdeleyerek, alternatif tedavi yöntemlerinin klinik kullanım alanlarını araştırmaktır. Gereç ve Yöntemler: PubMed, Cochrane Library, Evidence-Based Dentistry ve Google Scholar'da 2008-2018 yılları arasında yapılan uluslararası yayın taramasında; bitkisel tedaviler, ağız sağlığı, diş hekimliği, sarı kantaron, meyan kökü, sumak, karadut, aloe vera ve bu anahtar kelimelerin farklı kombinasyonları kullanılarak 179 yayına ulaşıldı. Bu yayınlardan, özetlerin okunması sonrasında belirlenen limitler dahilinde antimikrobiyal, antiinflamatuar, analjezik ve antiplak özelliklerinden herhangi birine sahip bitkilerle ilgili olan 50 yayın konu kapsamı içinde incelenmeye uygun görüldü. Bulgular: İncelenen yayınlarda, diş hekimliğinde bitkisel tedavi uygulamalarında analjezik ve antiinflamatuar özellikleri nedeniyle akut ağrıda sarı kantaron, antibakteriyel etkisiyle biyofilm oluşumunu azaltmak için sumak, avülse dişlerde taşıma ortamı olarak karadut, ağız ve diş enfeksiyonlarında karyojenik bakteriler ve perio-patojenlere karşı antimikrobiyal özelliğiyle aloe vera ve meyan kökü kullanıldığı tespit edildi. Sonuç: Tamamlayıcı ve alternatif bitkisel tedavi uygulamalarının, diş hekimliğinde kullanımının yaygınlaşması amacıyla konuya ilişkin bilimsel çalışmaların desteklenmesi gerekmektedir.

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“…The formation of mucosal ulcers is an end result of epithelial damage, and it occurs due to some specific causes, such as trauma, aphthous stomatitis, lichen planus and lichenoid reactions, cytotoxic effects of chemotherapy and radiation, and drug-induced hypersensitivity reactions and malignant settings [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…However, until the present moment, the precise role of the cytokines has not been clearly defined [5]. This process results in the development of erythematous, atrophic, and ulcerative lesions as a consequence of epithelial damage and death mediated through a complex series of molecular and cellular events that impede the quality of life of individuals with buccal mucositis [2,4,6].…”

Section: Introductionmentioning

confidence: 99%

Bilayer Mucoadhesive Buccal Film for Mucosal Ulcers Treatment: Development, Characterization, and Single Study Case

et al. 2020

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The formation of mucosal ulcers is an end result of epithelial damage, and it occurs due to some specific causes, such as trauma, aphthous stomatitis, lichen planus and lichenoid reactions, cytotoxic effects of chemotherapy and radiation, and drug-induced hypersensitivity reactions and malignant settings. This study focused on films for target drug delivery with respect to the treatment of the diseases of the oral mucosa, specifically mucositis. The results of a single clinical study as a pre-experimental design was performed and followed up to the outcome until 30 days. The polymeric film was prepared in a mucoadhesive bilayer structure: the basal layer with lidocaine HCl had a faster release than the apical layer with benzydamine HCl and N-acetyl-cysteine. Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), and SEM characterized the physical–chemical and morphological properties. The cell viability and cytotoxicity were evaluated in cell line MCF7. The transport mechanism of the solvent (swelling) and the drugs in the basal or apical layer (drug release) was explained with mathematical models. To evaluate the effect of movement inside the mouth, the folding endurance was determined. The mucoadhesive bilayer film is biologically safe and stimulates cellular proliferation. A single study in vivo demonstrated the therapeutic effect of the mucoadhesive bilayer film in buccal mucositis.

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Comparison of triamcinolone acetonide mucoadhesive film with licorice mucoadhesive film on radiotherapy‐induced oral mucositis: A randomized double‐blinded clinical trial

Cited by 36 publications

References 23 publications

TNF-alpha expression, evaluation of collagen, and TUNEL of Matricaria recutita L. extract and triamcinolone on oral ulcer in diabetic rats

TNF-alpha expression, evaluation of collagen, and TUNEL of Matricaria recutita L. extract and triamcinolone on oral ulcer in diabetic rats

Diş Hekimliğinde Tamamlayıcı Bitkisel Tedaviler

Bilayer Mucoadhesive Buccal Film for Mucosal Ulcers Treatment: Development, Characterization, and Single Study Case

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