Bu derlemenin amacı, diş hekimliği alanındaki bitkisel tedavilerin modern bilimin ışığında kullanılabilirliğini irdeleyerek, alternatif tedavi yöntemlerinin klinik kullanım alanlarını araştırmaktır. Gereç ve Yöntemler: PubMed, Cochrane Library, Evidence-Based Dentistry ve Google Scholar'da 2008-2018 yılları arasında yapılan uluslararası yayın taramasında; bitkisel tedaviler, ağız sağlığı, diş hekimliği, sarı kantaron, meyan kökü, sumak, karadut, aloe vera ve bu anahtar kelimelerin farklı kombinasyonları kullanılarak 179 yayına ulaşıldı. Bu yayınlardan, özetlerin okunması sonrasında belirlenen limitler dahilinde antimikrobiyal, antiinflamatuar, analjezik ve antiplak özelliklerinden herhangi birine sahip bitkilerle ilgili olan 50 yayın konu kapsamı içinde incelenmeye uygun görüldü. Bulgular: İncelenen yayınlarda, diş hekimliğinde bitkisel tedavi uygulamalarında analjezik ve antiinflamatuar özellikleri nedeniyle akut ağrıda sarı kantaron, antibakteriyel etkisiyle biyofilm oluşumunu azaltmak için sumak, avülse dişlerde taşıma ortamı olarak karadut, ağız ve diş enfeksiyonlarında karyojenik bakteriler ve perio-patojenlere karşı antimikrobiyal özelliğiyle aloe vera ve meyan kökü kullanıldığı tespit edildi. Sonuç: Tamamlayıcı ve alternatif bitkisel tedavi uygulamalarının, diş hekimliğinde kullanımının yaygınlaşması amacıyla konuya ilişkin bilimsel çalışmaların desteklenmesi gerekmektedir.

No abstract

Ankylosing Spondylitis is an autoimmune disease leading to inflammation in the joints and ligaments of the spine. ERAP1 is a major risk factor for AS and ERAP1 mutations may result in structural changes that alter the trimming efficiency, thereby altering the immune response. The underlying structural mechanisms of AS pathogenesis have not yet been fully elucidated. This study investigated ERAP1/ERAP2 allotypes using Molecular Dynamics in both monomeric and dimeric forms. ERAP1's domain IV has been found to be a favorable region for dimerization. Different allotype dimers exhibited different stability characteristics. Furthermore, the effects of allotypic variation were more pronounced in Hap2-/Hap8-coupled dimer structures and were more distinct in heterodimers. An analysis of the interchain region revealed that both H-bonding and electrostatic interactions between chains of Hap2–N392 heterodimer structures were lower than those between Hap2–Hap2 revealing that allotypic variations played a significant role in stabilizing and destabilizing dimer structures.

In this study, we aimed to evaluate the effects of four different photoactive dyes on the dentin adhesion of an epoxy resin-based root canal sealer. Methods: Sixty maxillary central incisors were used. Root canals were prepared up to the size Reciproc #40, and 2.5 mL of 5% NaOCl was used between each file. The teeth were divided into six groups: Group 1, distilled water (the control group); Group 2, methylene blue; Group 3, toluidine blue; Group 4, indocyanine green; Group 5, Congo red; and Group 6, diode laser. After final irrigation, each canal was irrigated with 2.5 mL of photoactive dye. Laser irradiation was applied for 1 min (940 nm wavelength, continuous mode, 1W). The canals were obturated with epoxy resin-based sealer and gutta-percha. Sections measuring 2 mm in thickness were taken from the apical, middle, and coronal thirds of the roots for the push-out test. Results: Although the photoactive dyes caused a decrease in the sealer bond strength values, there was no statistically significant difference from the control group or between the dyes. Diode laser irradiation increased bond strength, but there was again no significant difference. Bond strength values decreased from the coronal to the apical region (5.89±1.19, 3.93±0.76, and 3.18±0.63 MPa, respectively). Conclusion:We observed that the use of photoactive dyes to support root canal disinfection had no negative effect on the bond strength of a resin-based sealer.