Comparison of the Osteogenic Potential of Titanium- and Modified Zirconia-Based Bioceramics

Abstract

Zirconia is now favored over titanium for use in dental implant materials because of its superior aesthetic qualities. However, zirconia is susceptible to degradation at lower temperatures. In order to address this issue, we have developed modified zirconia implants that contain tantalum oxide or niobium oxide. Cells attached as efficiently to the zirconia implants as to titanium-based materials, irrespective of surface roughness. Cell proliferation on the polished surface was higher than that on the rough surfaces, but the converse was true for the osteogenic response. Cells on yttrium oxide (Y2O3)/tantalum oxide (Ta2O5)- and yttrium oxide (Y2O3)/niobium oxide (Nb2O5)-containing tetragonal zirconia polycrystals (TZP) discs ((Y, Ta)-TZP and (Y, Nb)-TZP, respectively) had a similar proliferative potential as those grown on anodized titanium. The osteogenic potential of MC3T3-E1 pre-osteoblast cells on (Y, Ta)-TZP and (Y, Nb)-TZP was similar to that of cells grown on rough-surface titanium. These data demonstrate that improved zirconia implants, which are resistant to temperature-induced degradation, retain the desirable clinical properties of structural stability and support of an osteogenic response.

Osteogenic Responses to Zirconia with Hydroxyapatite Coating by Aerosol Deposition

“…The zirconia discs were polished and finished with diamond pastes to generate a mirror-like surface. After being polished, the (Y, Nb)-TZP and (Y, Ta)-TZP surfaces were roughened by sandblasting with 50 μm Al 2 O 3 at 2 bar and 1 bar pressure, respectively, as we previously reported (Cho et al 2014).…”

“…However, reports of clinical failures caused by low-temperature degradation (LTD) indicated a need to improve the structural stability of this material (Gremillard and Chevalier 2008;Lughi and Sergo 2010). Modifications of zirconia with tantalum oxide (Ta [(Y, Ta)-TZP and (Y, Nb)-TZP, respectively] had osteogenic potential similar to that of those grown on anodized titanium, which is widely used as a dental implant material (Cho et al 2014). Material composition and surface topography are critical modulators of osseointegration.…”

Ceramic Dental Implants: A Literature Review

“…Y2O3-stabilized tetragonal zirconia polycrystals (Y-TZP) have high strength, toughness, and biocompatibility, and elicit biological responses that are similar to those induced by titanium. Therefore, Y-TZP is considered as a potential titanium alternative [11,17]. One unique feature of zirconia is its crack resistance, also called transformation toughening.…”

“…Where carved seashells and/or stones were placed into human jaw bone to replace missing teeth [11]. With the 18th century being the start of Endosseous oral implantology [10].…”

Avaliação histológica e histomorfométrica da energia superficial e molhabilidade em implantes de titânio grau IV e grau V: estudo experimental em coelhos

“…A zircônia tetragonal policristalina contendo ítrio (Y-TZP) é considerada como uma alternativa ao titânio pelo seu potencial de osseointegração, melhor biocompatibilidade, melhor resistência, bem como uma elevada resistência à flexão (800 a 1000 MPa) se comparada com outra cerâmica e a resistência à flexão da zircônia pode aumentar se haver modificação mecânica em sua superfície. Porém, a maioria dos estudos em implantes de zircônia é de curto prazo, sendo necessários novos estudos com ampla investigação (CHO et al, 2014;APRATIM et al, 2015).…”