Comparison of the diagnostic performances of two protocols of hand perfusion scintigraphy for Raynaud’s phenomenon

Abstract

Although both protocols for hand perfusion scintigraphy showed high specificity for diagnosing RP, the protocol with one-hand chilling showed higher diagnostic ability compared with that without one-hand chilling.

Perfusion Scintigraphy for the Evaluation of Patients with Raynaud’s Phenomenon

“…RP is common, ranging between 4 and 15% of the general population [2]. Incidence is known to be higher in colder climates, and it predominantly affects young women [1,[3][4][5].…”

“…There are many potential causes of secondary RP, including autoimmune or connective tissue disease (such as systemic sclerosis), arterial disease, frostbite, neoplasms, coagulation disorders, infection, medications, and activities that cause repeated vibration or pressure in the extremities [7]. RP can be an early symptom of connective tissue disorders; these include scleroderma (> 90%), mixed connective tissue disease (85%), and systemic lupus erythematosus (40%) [3,8,9]. Therefore, early diagnosis of RP is important, and careful follow-up of the patient is needed [3,10].…”

“…RP can be an early symptom of connective tissue disorders; these include scleroderma (> 90%), mixed connective tissue disease (85%), and systemic lupus erythematosus (40%) [3,8,9]. Therefore, early diagnosis of RP is important, and careful follow-up of the patient is needed [3,10].…”

Conversion to Paradoxical Finding on Technetium-99m-labeled RBC Scintigraphy after Treatment for Secondary Raynaud’s Phenomenon

“…Raynaud's phenomenon (RP) is characterized by episodic vasospasm and ischemia of the extremities in response to stress or exposure to cold [1]. There have been several studies of RP using perfusion scintigraphy [2][3][4][5][6]. After cold challenge, patients with RP show two types of findings on perfusion scintigraphy [4,5]: (1) decreased perfusion or blood pool activity or (2) increased perfusion or blood pool activity [4].…”

The own method and program of isotopic quantitative assessment of perfusion in muscles of upper limbs

“…Our researches have been published many times [11,12]. All scientific and clinical studies that deal with the issues of muscle perfusion are worth attention [13][14][15][16][17][18][19][20][21][22][23]. There are still trials to find safe and highly sensitive diagnostic tests that would assess muscle perfusion quantitatively not only in the area of lower limbs.…”