Perfusion Scintigraphy for the Evaluation of Patients with Raynaud’s Phenomenon

Chong, Ari

doi:10.1007/s13139-020-00671-6

Cited by 4 publications

(5 citation statements)

References 24 publications

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“…These methods are more sensitive to vascular feature information, more reliable, and stable, and they have great advantages over unsupervised learning methods [ 7 ]. Traditional supervised learning methods are based on the manual extraction of the multidimensional features of retinal vessels and the subsequent selection of a suitable classifier for classification.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Fundus Blood Flow Perfusion in Patients with Diabetic Retinopathy after PPV with Fundus Color Doppler Based on Big Data Mining

Wang

Zhao³

2022

Journal of Healthcare Engineering

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In this paper, we have carefully investigated the clinical phenotype and genotype of patients with Johanson-Blizzard syndrome (JBS) with diabetes mellitus as the main manifestation. Retinal vessel segmentation is an important tool for the detection of many eye diseases and plays an important role in the automated screening system for retinal diseases. A segmentation algorithm based on a multiscale attentional resolution network is proposed to address the problem of insufficient segmentation of small vessels and pathological missegmentation in existing methods. The network is based on the encoder-decoder architecture, and the attention residual block is introduced in the submodule to enhance the feature propagation ability and reduce the impact of uneven illumination and low contrast on the model. The jump connection is added between the encoder and decoder, and the traditional pooling layer is removed to retain sufficient vascular detail information. Two multiscale feature fusion methods, parallel multibranch structure, and spatial pyramid pooling are used to achieve feature extraction under different sensory fields. We collected the clinical data, laboratory tests, and imaging examinations of JBS patients, extracted the genomic DNA of relevant family members, and validated them by whole-exome sequencing and Sanger sequencing. The patient had diabetes mellitus as the main manifestation, with widened eye spacing, low flat nasal root, hypoplastic nasal wing, and low hairline deformities. Genetic testing confirmed the presence of a c.4463 T > C (p.Ile1488Thr) pure missense mutation in the UBR1 gene, which was a novel mutation locus, and pathogenicity analysis indicated that the locus was pathogenic. This patient carries a new UBR1 gene c.4463 T > C pure mutation, which improves the clinical understanding of the clinical phenotypic spectrum of JBS and broadens the genetic spectrum of the UBR1 gene. The experimental results showed that the method achieved 83.26% and 82.56% F1 values on CHASEDB1 and STARE standard sets, respectively, and 83.51% and 81.20% sensitivity, respectively, and its performance was better than the current mainstream methods.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Fundus Blood Flow Perfusion in Patients with Diabetic Retinopathy after PPV with Fundus Color Doppler Based on Big Data Mining

Wang

Zhao³

2022

Journal of Healthcare Engineering

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“…Different protocols exist, with or without cooling the fingers. However, the one-hand-chilling method is often preferred [ 56 , 57 ]. Regardless of the protocol, perfusion scintigraphy has proven effective in distinguishing between normal and RP, as well as between primary and secondary RP [ 56 , 57 ].…”

Section: Diagnosismentioning

confidence: 99%

“…However, the one-hand-chilling method is often preferred [ 56 , 57 ]. Regardless of the protocol, perfusion scintigraphy has proven effective in distinguishing between normal and RP, as well as between primary and secondary RP [ 56 , 57 ]. Dynamic blood flow studies measure finger-to-palm ratios, helping differentiate healthy individuals from those with RP.…”

Section: Diagnosismentioning

confidence: 99%

“…Dynamic blood flow studies measure finger-to-palm ratios, helping differentiate healthy individuals from those with RP. Static blood pool phase studies, on the other hand, aid in discriminating between primary and secondary RP [ 41 , 56 ]. Fig.…”

Section: Diagnosismentioning

confidence: 99%

“…Perfusion scintigraphy may be done with or without cold stimulation. The one-hand chilling method is widely used for cold stimulation, wherein the non-dominant hand or the hand with more severe symptoms is dipped in cold water (4°C) and the ratio of the finger blood-pool count of the chilled hand to that of the ambient hand (normal>0.8) is calculated [ 56 ]. (A) Negative result of perfusion scintigraphy: the ratio of the finger blood-pool count of the chilled hand to that of the ambient hand was 0.98.…”

Section: Figmentioning

confidence: 99%

See 2 more Smart Citations

Raynaud’s Phenomenon: A Current Update on Pathogenesis, Diagnostic Workup, and Treatment

Ture,

Lee,

Kim

et al. 2024

Vasc Specialist Int

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Dynamic blood flow imaging with 99mTc-hydroxymethylene diphosphonate as a therapeutic response marker in patients with Raynaud’s phenomenon

Yoo,

Cheon

2023

Sci Rep

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We evaluated the predictive value of dynamic blood flow scintigraphy with 99mTc-HDP (hydroxymethylene diphosphonate) for therapeutic response in patients with Raynaud’s phenomenon (RP). Eighty patients who underwent dynamic blood flow scintigraphy using the one-hand chilling method were enrolled. We analyzed the quantitative variables as the ratio of chilled fingers to ambient fingers (CAfinger), that of the chilled hand to ambient hand (CAhand), and that of chilled fingers to ambient palm (FPR) (CAFPR) at 15 and 30 s after 99mTc-HDP bolus injection. Total cumulative radioactivity counts for 180 s were obtained. We evaluated the clinical utility of these quantitative parameters with other clinical variables, including RP severity, therapeutic compliance, types of RP, and scintigraphic interpretation of findings in patients with RP. Fifty-two patients showed poor therapeutic response. There were significant differences between good- and poor-therapeutic responder groups in RP intensity (p = 0.003), CAfinger15s (p = 0.008), CAfinger30s (p = 0.002), CAfinger180s (p = 0.011), CAhand15s (p = 0.008), CAhand30s (p = 0.007), CAhand180s (p = 0.017), CAFPR30s (p = 0.004), and CAFPR180s (p = 0.002). After multivariate logistic regression analysis, only CAfinger30s (p = 0.002) had an independent predictive value of the therapeutic response. 99mTc-HDP dynamic blood flow scintigraphy could be helpful in predicting the therapeutic response in patients with RP.

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Perfusion Scintigraphy for the Evaluation of Patients with Raynaud’s Phenomenon

Cited by 4 publications

References 24 publications

Evaluation of Fundus Blood Flow Perfusion in Patients with Diabetic Retinopathy after PPV with Fundus Color Doppler Based on Big Data Mining

Evaluation of Fundus Blood Flow Perfusion in Patients with Diabetic Retinopathy after PPV with Fundus Color Doppler Based on Big Data Mining

Raynaud’s Phenomenon: A Current Update on Pathogenesis, Diagnostic Workup, and Treatment

Dynamic blood flow imaging with 99mTc-hydroxymethylene diphosphonate as a therapeutic response marker in patients with Raynaud’s phenomenon

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