Comparison of osteointegration property between PEKK and PEEK: Effects of surface structure and chemistry

Yuan, Bo; Qian, Cheng; Zhao, Rui; Zhu, Xiangdong; Yang, Xiao; Yang, Xi; Zhang, Kai; Song, Yueming; Zhang, Xingdong

doi:10.1016/j.biomaterials.2018.04.014

Cited by 146 publications

(94 citation statements)

References 54 publications

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“…To quantify the bone formation at the bone–implant interface, the bone–implant contact ratio (BICR) was calculated as the proportion of the bone contact length to the total perimeter of the specimen using an analytical method similar to that described in previous studies. 31 , 32…”

Section: Methodsmentioning

confidence: 99%

<p>Electrochemical Deposition of Nanostructured Hydroxyapatite Coating on Titanium with Enhanced Early Stage Osteogenic Activity and Osseointegration</p>

Lu¹,

Chen²,

Yuan³

et al. 2020

IJN

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Purpose The aim of research is to fabricate nanostructured hydroxyapatite (HA) coatings on the titanium via electrochemical deposition (ED). Additionally, the biological properties of the ED-produced HA (EDHA) coatings with a plate-like nanostructure were evaluated in vitro and in vivo by undertaking comparisons with those prepared by acid/alkali (AA) treatment and by plasma spray-produced HA (PSHA) nanotopography-free coatings. Materials and Methods Nanoplate-like HA coatings were prepared through ED, and nanotopography-free PSHA coatings were fabricated. The surface morphology, phase composition, roughness, and wettability of these samples were investigated. Furthermore, the growth, proliferation, and osteogenic differentiation of MC3T3-E1 cells cultured on each sample were evaluated via in vitro experiments. Histological assessment and push-out tests for the bone–implant interface were performed to explore the effect of the EDHA coatings on the interfacial osseointegration in vivo. Results XRD analysis showed that the strongest intensity for the EDHA coatings was at the (002) plane rather than at the regular (211) plane. Relatively higher surface roughness and greater wettability were observed for the EDHA coatings. Cellular experiments revealed that the plate-like nanostructured EDHA coatings not only possessed an ability, similar to that of PSHA coatings, to promote the adhesion and proliferation of MC3T3-E1 cells but also demonstrated significantly enhanced early or intermediate markers of osteogenic differentiation. Significant osseointegration enhancement in the early stage of implantation period and great bonding strength were observed at the interface of bone and EDHA samples. In comparison, relatively weak osseointegration and bonding strength of the bone–implant interface were observed for the AA treatment. Conclusion The biological performance of the plate-like nanostructured EDHA coating, which was comparable with that of the PSHA, improves early-stage osteogenic differentiation and osseointegration abilities and has great potential for enhancing the initial stability and long-term survival of uncemented or 3D porous titanium implants.

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Section: Methodsmentioning

confidence: 99%

<p>Electrochemical Deposition of Nanostructured Hydroxyapatite Coating on Titanium with Enhanced Early Stage Osteogenic Activity and Osseointegration</p>

Lu¹,

Chen²,

Yuan³

et al. 2020

IJN

Self Cite

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“…The recent abutment material Pekkton ® is a polyetherketoneketone (PEKK) belonging to the material group of polyaryletherketone and differs from polyetheretherketone (PEEK) materials through replacement of one ether group with a second ketone group. Both PEKK and PEEK are promising alternative materials for dental implants that have good surface modification properties with high mechanical stability and sufficient osseointegration, with PEKK performing better than PEEK (El Awadly et al., 2020; Knaus, Schaffarczyk, & Colfen, 2020; Mishra & Chowdhary, 2019; Yuan et al., 2018). PEKK manufactured to possess nanostructured surface features has demonstrated superior antibacterial properties to standard PEEK in orthopaedic implant applications (Wang, Bhardwaj, & Webster, 2017).…”

Section: Introductionmentioning

confidence: 99%

Biofilm formation on metal alloys, zirconia and polyetherketoneketone as implant materials in vivo

Zeller

Stöckli

Zaugg

et al. 2020

Clinical Oral Implants Res

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Objectives This study investigated biofilm formation on discs of metal alloys, zirconia and polyetherketoneketone in vivo. Material and Methods Sixteen healthy volunteers conducted two runs of 24 hr each wearing an intraoral splint with 15 discs representing five different materials (gold‐based [EL] and silver‐based [PA] noble metal alloys; zirconia [ZR]; polyetherketoneketone [PEKK]; titanium zirconium alloy [TiZr]). Safranin staining assays and colony‐forming unit (CFU) counts were conducted. Linear mixed‐effects models were used to compare materials, and geometric mean ratios with 95% confidence interval were calculated with the level of significance set at α = 0.05. Results Less biofilm mass and lower CFU counts were found on PA and EL, while ZR and PEKK developed similar levels as the reference material TiZr alloy. Compared with PA, biofilm mass was 1.5 times higher for EL (p = .004), 1.7 times higher for PEKK (p < .001), 2.2 times higher for TiZr (p < .001) and 2.4 times higher for ZR (p < .001). The culturing method confirmed these results for EL and PA with lower CFU compared to TiZr. The biomass staining technique and cell culturing correlated for EL and PA. Conclusion Silver‐based noble alloy and gold‐based high noble alloy demonstrated the least biofilm formation indicating a potential clinical use as material for implant components in the transmucosal compartment. Zirconia and Polyetherketoneketone revealed similar results as the reference material titanium zirconium alloy used in commercially available titanium dental implant.

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“…Furthermore, the scaffold should trigger the formation of new bones or osteogenic differentiation via biomolecular signaling and promoting osteodifferentiation (osteoinduction) [ 61 , 62 ]. The scaffolds should enhance cellular activity towards scaffolds-host tissue integration that integrates with native tissue and fills the void or defect (osteointegration) [ 63 , 64 ]. The schematic representation of osteoinduction, osteoconduction and osteointegration is shown in Figure 2 .…”

Section: Native Bone Structure and Compositionmentioning

confidence: 99%

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

2018

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Bone tissue engineering is an interdisciplinary field where the principles of engineering are applied on bone-related biochemical reactions. Scaffolds, cells, growth factors, and their interrelation in microenvironment are the major concerns in bone tissue engineering. Among many alternatives, electrospinning is a promising and versatile technique that is used to fabricate polymer fibrous scaffolds for bone tissue engineering applications. Copolymerization and polymer blending is a promising strategic way in purpose of getting synergistic and additive effect achieved from either polymer. In this review, we summarize the basic chemistry of bone, principle of electrospinning, and polymers that are used in bone tissue engineering. Particular attention will be given on biomechanical properties and biological activities of these electrospun fibers. This review will cover the fundamental basis of cell adhesion, differentiation, and proliferation of the electrospun fibers in bone tissue scaffolds. In the last section, we offer the current development and future perspectives on the use of electrospun mats in bone tissue engineering.

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Comparison of osteointegration property between PEKK and PEEK: Effects of surface structure and chemistry

Cited by 146 publications

References 54 publications

<p>Electrochemical Deposition of Nanostructured Hydroxyapatite Coating on Titanium with Enhanced Early Stage Osteogenic Activity and Osseointegration</p>

<p>Electrochemical Deposition of Nanostructured Hydroxyapatite Coating on Titanium with Enhanced Early Stage Osteogenic Activity and Osseointegration</p>

Biofilm formation on metal alloys, zirconia and polyetherketoneketone as implant materials in vivo

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

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