Comparison of Hemogram Parameters in Febrile Seizures Types

Abstract

Aim: Febrile seizures (FS) are among the most common neurological emergencies during childhood and clinically classified into two types, being simple febrile seizures (SFS) and complicated febrile seizures (CFS). The differentiation between FS types is important, in that they are associated with different morbidity and mortality risks and it is based on the clinical characteristics of each seizure, however there is currently no laboratory test that can guide this differentiation. In this study, the relationship between FS types and hemogram parameters was evaluated and potential use of these parameters in differential diagnosis was investigated. Material and Methods: This retrospective study included a total of 133 patients whose first FS met the criteria of an FS, and whose hemogram results were available. The American Academy of Pediatrics criteria were used to confirm the diagnosis. The patients were divided into two groups as SFS and CFS. Results: Hemoglobin (Hb), hematocrit (HCT), mean platelet volume (MPV), neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) differed significantly between two groups (p<0.001, p=0.002, p=0.033, p<0.001, p<0.001, respectively), while no significant difference was identified in total blood count parameters. Moreover, MPV was significantly higher in CFS group than in SFS group. Conclusion: This is one of the few studies investigating the potential relationship between hemogram parameters and FS types in children. We believe that, although they do not ensure a clear differentiation, Hb, MPV, NLR and PLR may be useful to clinicians in differentiating between FS types, particularly in patients with an unclear seizure history.

The predictive role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in children with simple febrile seizures

“…Iron concentrations in blood could not be analyzed in the present study since the test was not routinely requested. One previous study comparing types of febrile seizure determined statistically significantly lower Hb, Htc and MCV values in patients with complex febrile seizure [19]. Similarly in the present study, we also observed significantly lower Hb, Htc and MCV values in the febrile convulsion group.…”

“…Türay et al observed significantly higher RDW in febrile seizure recurrence [21]. Örnek et al observed higher mean RDW in their complex febrile seizure group, but the difference was not statistically significant [19]. RDW was significantly higher in the simple febrile seizure group in the present study.…”

“…Studies have reported significantly higher NLR values in complex febrile seizure groups among patients with febrile seizures [8,26]. Another study reported significantly elevated NLR and PLR values [19]. NLR and PLR values were also significantly higher in the simple febrile seizure group in the present study.…”

The Impact of Neutrophil-Lymphocyte Ratio in Febrile Seizures: A Systematic Review and Meta-Analysis

“…Of the 17 studies, ten studies reported NLR levels in children with FS and compared them with that of controls [ 8 , 11 , 13 , 15 – 18 , 20 , 22 , 24 ], and 11 studies compared the NLR levels in children with simple FS with those of children with complex FS [ 8 – 10 , 12 – 14 , 16 , 19 – 21 , 23 ].…”

“…The NLR, which can be calculated by absolute neutrophil count divided by absolute lymphocyte count, assessed based on a complete blood count (CBC) differential test, has been investigated in a number of previous studies involving cardiovascular diseases, malignancies [5,6], and some neurologic disorders [7]; however, the relevance between NLR and FS is still unclear. Although the controversy about the association between NLR and FS has raged unabated for about a decade [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24], no systematic review has been reported. Therefore, our systematic review was conducted to determine whether NLR is associated with FS susceptibility and FS types in children.…”