Comparison of essential oils compositions of Ferula assa-foetida obtained by supercritical carbon dioxide extraction and hydrodistillation methods

Chemotaxonomic Significance of the Essential Oils of 18 Ferula Species (Apiaceae) from Iran

“…While the leave essential oils of F. latisecta characterized by Iranshahi et al [17] exhibited similarity to the present oil, the oil extracted from the aerial parts of this species by Habibi et al [18] showed a different general oil profile. In the essential oil of F. assa-foetida reported by Khajeh et al [29] and our present oil, 1-methylpropyl (1E)-prop-1-en-1-yl disulfide (3) was detected as the main constituent. In the essential oil of F. foetida, which has been reported here for the first time, 14 compounds, comprising 97.3% of the total oil, were detected.…”

Sulphur-containing compounds in the essential oil ofFerula alliacearoots and their mass spectral fragmentation patterns

“…Other analytical settings were: oven temperature: 50 C (5 min), 50-250 C (3 C/min), 250 C (10 min); injector temperature 250 C; injection volume: 0.1 L; split ratio: 1:50; carrier gas: helium at 1.1 mL/min; ionization potential: 70 eV; ionization current: 150 A; and mass range: 35-465 mui. Identification of individual compounds was made by comparison of their mass spectra and retention indices (RI) with those of authentic samples and those given in the literature (Khajeh et al 2005;Adams 2007). Quantification of the relative amount of each individual component was performed according to the area percentage method without consideration of calibration factor.…”

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“…It has been recently published that the plant has essential oil components. [29] In this study, antioxidant activity of the essential oil components from the F. asafoetida was examined by in vitro 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) and nitric oxide radical scavenging assay, reducing power, linoleic acid and iron ion chelation power, and establishing usefulness of this plant. The extract from aerial parts of F. asafoetida showed good but different levels of antioxidant activity in all the models studied.…”

“…Many studies stated about tumor reducing activity of Asafoetida using oral administration of the extracts in mice by intraperitoneal transplantation in Ehrlich ascites tumor. [31] The cytotoxicity may be due to the high contents of essential oils in F. asafoetida which are toxic for biological systems [29,32,33] [34] The sesquiterpene prenylated coumarin derivative ferulenol of Asafoetida, which cause toxicity to the plant and responsible for antibacterial properties as well as cytotoxicity toward human tumor cell lines. The most of the sesquiterpene coumarins were stored in the root part [35] which may be deliberated as potential biological compounds for the treatment of malignancies.…”