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Upadhyay, Prabhat Kumar

doi:10.22377/ijgp.v11i02.1033

Cited by 5 publications

(2 citation statements)

References 36 publications

(53 reference statements)

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“… Ferula asafoetida H. Karst. Apiaceae Asafoetida Resins Muscle relaxant Memory enhancer Digestive disorders Hypotensive and anthelmintic Hepatoprotective Antispasmodic Treatment of unwanted abortion, unusual pain, sterility, leucorrhea, excessive menstruation, loose stools, flatulence Upadhyay (2017) 36. Hyssopus officinalis L. Lamiaceae Hyssop Leaf Cough suppressant Gastrointestinal troubles Epilepsy Microbial infections Ulcers and spasm Antispasmodic Expectorant Tahir et al (2018) 37.…”

Section: Ethnomedicinal Uses Of Indian Spicesmentioning

confidence: 99%

Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways

Singh

Yadav

2022

Current Research in Food Science

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Section: Ethnomedicinal Uses Of Indian Spicesmentioning

confidence: 99%

Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways

Singh

Yadav

2022

Current Research in Food Science

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“…Instead of being an irreplaceable part of food accessories, they have their history in the field of folk medicine since they possess different phytochemicals (Amalraj and Gopi, 2017). These phytochemicals have long been used to cure several ailments, and they can be a promising alternative to conventional medical therapies (Upadhyay, 2017). The Apiaceae family consists of about 455 genera and 3,600-3,751 plants species that belong to this family are often used in the form of spices.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of the Ferula Genus (Apiaceae)

Sonigra

Meena

2021

Front. Pharmacol.

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The genus Ferula is the third largest and a well-known genus of the Apiaceae family. It is categorized in the Peucedaneae tribe and Ferulinae subtribe of the Apiaceae family. At present, about 180 Ferula species have been reported. The genus is mainly distributed throughout central and South-West Asia (especially Iran and Afghanistan), the far-East, North India, and the Mediterranean. The genus Ferula is characterized by the presence of oleo-gum-resins (asafoetida, sagapenum, galbanum, and ammoniacum) and their use in natural and conventional pharmaceuticals. The main phytochemicals present in the genus Ferula are as follows: coumarin, coumarin esters, sesquiterpenes, sesquiterpene lactones, monoterpene, monoterpene coumarins, prenylated coumarins, sulfur-containing compounds, phytoestrogen, flavonoids and carbohydrates. This genus is considered to be a valuable group of medicinal plants due to its many different biological and pharmacological uses as volatile oils (essential oils). Numerous biological activities are shown by the chemical components of the essential oils obtained from different Ferula species. Because this genus includes many bioactivities such as antimicrobial, insecticidal, antioxidant, cytotoxic, etc., researchers are now focusing on this genus. Several reviews are already available on this particular genus, including information about the importance and the uses of all the phytochemicals found in the species of Ferula. Despite this, no review that specifically provides information about the biological activities of Ferula-derived essential oils, has been published yet. Therefore, the present review has been conducted to provide important information about the chemical profile, factors affecting the chemical composition, and biological activities of essential oils of the Ferula species.

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Ferula haussknechtii Inhibits Acetylcholinesterase: In‐Vitro and In‐Silico Studies

Babaei,

Ebadi,

Dastan

2023

ChemistrySelect

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Alzheimer's disease (AD) is a destructive neurological disease. Approved therapies that target the cholinergic system to control the symptoms have various complications. Natural compounds that inhibit the acetylcholinesterase (AChE) enzyme can promote the development of new drugs. Nature‐derived compounds are more compatible with biological systems in comparison to synthetic library. Ferula haussknechtii is a native species of Iran. In study, we evaluated the effects of its essential oil and extracts on the inhibition of AChE through in vitro and in silico methods. The essential oil was extracted by Clevenger apparatus. Extracts were prepared by maceration for 72 hours. The Ellman's test was used to measure the inhibitory effects of the samples. The interaction of the main constituents of the essential oil with AChE was investigated by Coarse Grained molecular dynamics (CG‐MD) simulation. Essential oil inhibited the AChE with IC50: 44.6 μg/ml. Among different extracts, hydroalcoholic extract with IC50: 41.4 μg/ml exhibited the most potent inhibitory effect. Based on the results of 1 μs CG‐MD simulation, the major constituents of the essential oil inhibited the AChE by binding to the PAS site. The constituents of F. haussknechtii could be considered as a rich source for discovering and designing new AChE inhibitors.

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Untitled

Cited by 5 publications

References 36 publications

Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways

Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways

Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of the Ferula Genus (Apiaceae)

Ferula haussknechtii Inhibits Acetylcholinesterase: In‐Vitro and In‐Silico Studies

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