Sulphur-containing compounds in the essential oil of<i>Ferula alliacea</i>roots and their mass spectral fragmentation patterns

Kasaian, Jamal; Asili, Javad; Iranshahi, Mehrdad

doi:10.3109/13880209.2016.1152279

Cited by 23 publications

(20 citation statements)

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“…Ferula spp. and essential oils derived from these species are another important source of unique organosulfur compounds [14,16,[43][44][45]. In the present study, we defined the chemical profile of essential oils extracted from different parts of F. iliensis and evaluated the effect of these oils on phagocyte functions in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 66 constituents were identified in the FEOs, with organosulfur compounds (E)-propenyl sec-butyl disulfide and (Z)-propenyl sec-butyl disulfide being the major components. Previously, sec-butyl disulfide derivatives of sulfur-containing compounds were found in essential oils and/or ole-gum resins obtained from various Ferula spp [14,16,[43][44][45]. It should be noted that the sec-butyl feature of sulfur-containing compounds is considered to be the chemotaxonomic marker of the family Apiaceae [44].…”

Section: Discussionmentioning

confidence: 99%

“…Previously, sec-butyl disulfide derivatives of sulfur-containing compounds were found in essential oils and/or ole-gum resins obtained from various Ferula spp [14,16,[43][44][45]. It should be noted that the sec-butyl feature of sulfur-containing compounds is considered to be the chemotaxonomic marker of the family Apiaceae [44]. All FEOs, with the exception of FEO Fr , also had reasonable levels of 10-epi-g-eudesmol (2.9-10.3%) and guaiol-type sesquiterpenes (up to 8.5%).…”

Section: Discussionmentioning

confidence: 99%

“…All FEOs, with the exception of FEO Fr , also had reasonable levels of 10-epi-g-eudesmol (2.9-10.3%) and guaiol-type sesquiterpenes (up to 8.5%). Among Ferula spp., eudesmane-type sesquiterpenes have been reported in essential oils of F. communis L., F. assa-foetida L., and F. alliacea Boiss [14,44,46].…”

Section: Discussionmentioning

confidence: 99%

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Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Özek

Schepetkin

Utegenova

et al. 2017

Journal of Leukocyte Biology

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Essential oil extracts from have been used traditionally in Kazakhstan for treatment of inflammation and other illnesses. Because little is known about the biologic activity of these essential oils that contributes to their therapeutic properties, we analyzed their chemical composition and evaluated their phagocyte immunomodulatory activity. The main components of the extracted essential oils were ()-propenyl -butyl disulfide (15.7-39.4%) and ()-propenyl -butyl disulfide (23.4-45.0%). essential oils stimulated [Ca] mobilization in human neutrophils and activated ROS production in human neutrophils and murine bone marrow phagocytes. Activation of human neutrophil [Ca] flux by essential oils was dose-dependently inhibited by capsazepine, a TRPV1 channel antagonist, indicating that TRPV1 channels mediate this response. Furthermore, essential oils stimulated Ca influx in TRPV1 channel-transfected HEK293 cells and desensitized the capsaicin-induced response in these cells. Additional molecular modeling with known TRPV1 channel agonists suggested that the active component is likely to be ()-propenyl -butyl disulfide. Our results provide a cellular and molecular basis to explain at least part of the beneficial therapeutic properties of FEOs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Özek

Schepetkin

Utegenova

et al. 2017

Journal of Leukocyte Biology

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“…Ferula spp. are a good source of biologically active compounds, such as sesquiterpenes, terpenoid coumarins, and sulfur containing compounds [ 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. The genus Ferula (Apiaceae) comprises ∼185 species distributed throughout Central Asia, the Mediterranean, and northern Africa, and many species of Ferula L. have been used in traditional medicine [ 13 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antibacterial Activity of Essential Oils from Ferula L. Species against Methicillin-Resistant Staphylococcus aureus

et al. 2018

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Essential oils (EOs) were obtained by hydrodistillation of various parts of Ferula ovina (Boiss.) Boiss., Ferula iliensis Krasn. ex. Korovin, and Ferula akitschkensis B. Fedtsch. ex Koso-Pol., collected in the flowering/budding and fruiting stages. Eight samples of EOs isolated from F. ovina and four samples from F. akitsckensis were analyzed by gas chromatography–mass spectrometry (GC-MS). The major constituents of F. ovina EOs were α-pinene (6.9–47.8%), β-pinene (1.5–7.1%), sabinene (0.1–20.5%), β-phellandrene (0–6.5%), trans-verbenol (0.9–7.4%), eremophilene (3.1–12%), and 6Z-2,5,5,10-tetramethyl-undeca-2,6,9-trien-8-one (0–13.7%). The major constituents of F. akitsckensis EOs were α-pinene (0–46.2%), β-pinene (0–47.9%), sabinene (0–28.3%), eremophilene (0–10.6), β-caryophyllene (0–7.5%), himachalen-7-ol (0–28.2%), and an himachalol derivative (0–8.3%). Samples of EOs from F. ovina, F. iliensis, and F. akitsckensis were evaluated for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) pulse-field gel electrophoresis type USA300 (LAC). EOs from F. ovina exhibited the highest antibacterial activity compared to samples from other Ferula spp., with the most potent EOs being isolated from roots at the flowering and fruiting stages and stems at the fruiting stage (IC50 values of 19.1, 20.9, and 22.9 µg/mL, respectively). Although EOs demonstrated concentration-dependent inhibition of MRSA growth, analysis of the major constituents (α-pinene, β-pinene, and sabinene) showed that they had low activity, suggesting that other components were likely responsible for the observed bioactivity of the unfractionated EOs. Indeed, correlation of the GC-MS data with antibacterial activity suggested that the putative components responsible for antibacterial activity were, either individually or in combination, eremophilene and trans-verbenol. Overall, these results suggest that the EOs from F. ovina could have potential for use as alternative remedies for the treatment of infectious diseases caused by MRSA.

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Chemical characterization and biological activity of essential oils from the aerial part and root ofFerula haussknechtii

Arjmand

Dastan

2019

Flavour & Fragrance J

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Ferula genus belongs to Umbelliferae family. Plants with this kind of genus are distributed in an extended region such as central Asia and Mediterranean area. Ferula species are used in traditional medicine as a remedy in different kinds of illnesses and also in different kinds of industries. The Ferula haussknechtii H. Wolff ex Rech. f. is one of the flora species in Iran which in this research the essential oil of its aerial parts and root was extracted by Clevenger apparatus. After that, theirs compounds were recognized using gas chromatography methods (GC‐MS and GC‐FID) and their amount was determined. Antibacterial activity of essential oils was examined, and phytochemical screening on the plant's extracts was done too. GC‐MS/FID method identified 62 compounds in root and 64 compounds in aerial parts of this plant which were 94.6 and 92.8 percent of their respective whole essential oil. Camphene, α‐pinene, and isoverbanol had the most percent in both essential oils. Antibacterial tests on root and aerial parts of plant essential oils on 4 g‐negative and 5 g‐positive bacteria were done. Results concluded that essential oils were effective on the Bacillus pumilus, Staphylococcus epidermidis, and Staphylococcus aureus (17‐18mm, 7.5 mg/mL); therefore, this plant can be useful in medicine and food industry as an antibacterial agent.

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Sulphur-containing compounds in the essential oil ofFerula alliacearoots and their mass spectral fragmentation patterns

Cited by 23 publications

References 24 publications

Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Chemical Composition and Antibacterial Activity of Essential Oils from Ferula L. Species against Methicillin-Resistant Staphylococcus aureus

Chemical characterization and biological activity of essential oils from the aerial part and root ofFerula haussknechtii

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