Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Abstract

Essential oil extracts from have been used traditionally in Kazakhstan for treatment of inflammation and other illnesses. Because little is known about the biologic activity of these essential oils that contributes to their therapeutic properties, we analyzed their chemical composition and evaluated their phagocyte immunomodulatory activity. The main components of the extracted essential oils were ()-propenyl -butyl disulfide (15.7-39.4%) and ()-propenyl -butyl disulfide (23.4-45.0%). essential oils stimulated [Ca] mobilization in human neutrophils and activated ROS production in human neutrophils and murine bone marrow phagocytes. Activation of human neutrophil [Ca] flux by essential oils was dose-dependently inhibited by capsazepine, a TRPV1 channel antagonist, indicating that TRPV1 channels mediate this response. Furthermore, essential oils stimulated Ca influx in TRPV1 channel-transfected HEK293 cells and desensitized the capsaicin-induced response in these cells. Additional molecular modeling with known TRPV1 channel agonists suggested that the active component is likely to be ()-propenyl -butyl disulfide. Our results provide a cellular and molecular basis to explain at least part of the beneficial therapeutic properties of FEOs.

Chemical Composition and Antibacterial Activity of Essential Oils from Ferula L. Species against Methicillin-Resistant Staphylococcus aureus

“…Hydrodistillation of the umbels with seeds and stems produced 0.7 and 0.02% EOs, respectively [ 12 ]. The chemical composition of all EOs from F. iliensis were reported recently, and yields of their EOs varied from 0.4 to 1.1% [ 19 ].…”

“…ex. Korovin, is a native plant of Kazakhstan that is widely used by the local population as an anti-inflammatory treatment [ 19 ]. The main constituents of most reported EOs from Ferula spp.…”

“…Monoterpenes and sesquiterpenes are a frequently occurring group of compounds in EOs and have a broad spectrum of pharmacological properties, including antimicrobial activity [ 24 , 25 , 26 , 27 , 28 ]. Previously, we reported the chemical composition and immunomodulatory activity of EOs isolated from Ferula iliensis and Ferula akitschkensis [ 12 , 19 ]. Likewise, several sulfur compounds, including sec-butyl disulfide derivatives, were found in EOs and/or ole-gum resins obtained from various Ferula spp.…”

Much More Than a Pleasant Scent: A Review on Essential Oils Supporting the Immune System

“…Allium sativum (garlic) [22] Eucalyptus globulus (eucalyptus) [23,24] eugenol (from Syzygium aromaticum, clove) [25,26] Ferula iliensis [27] frankincense EO (derived from Boswellia carterii) [28] Lavandula angustifolia (lavender) [29] Pituranthos tortuosus [30] Schinus molle [31] Syzygium cumini (jambolão) [32] Thymus vulgaris (thyme) [33] In Vivo Pre-Clinical Studies…”

“…EO extracts from various parts of Ferula iliensis dose-dependently enhanced superoxide anion production in isolated human neutrophils and bone marrow leukocytes from mice. The EOs stimulated calcium influx by activation of TRPV1 channels since capsazepine, a TRPV1 channel antagonist was found to inhibit its activation [27]. Garlic (Allium sativum) EO and some of its pure organosulfur compounds augmented functional responses in isolated human neutrophils, resulting in increased calcium flux and/or reactive oxygen species (ROS) production [22].…”