Comparative study of the speed of acid‐suppressing effects of oral administration of cimetidine and famotidine

Abstract

Background and Aim: H2 histamine receptor antagonists (H2RAs) are widely used in patients with acid-related diseases, and the onset of antisecretory activity of H2RAs is reported to be faster than that of proton pump inhibitors (PPIs). The aim of this study was to compare the rapidity of onset of antisecretory activity of cimetidine and famotidine when orally administered. Methods: Fifteen healthy male Japanese volunteers (five H. pylori-positive and 10 H. pylori-negative) participated in a randomized cross-over study. All subjects were examined three times by ambulatory 6-h pH monitoring (from 17:30 to 23:30) with no medication or oral administration of 400 mg of cimetidine or 20 mg of famotidine. Drugs were administered at 19:30 after eating a standard meal, and plasma concentrations were also examined for 4 h periods. Results: The plasma concentration of cimetidine increased rapidly after oral administration, while that of famotidine increased gradually. Intragastric pH was increased and percentage time with pH < 4.0 decreased significantly 2 h after administration of either cimetidine or famotidine. There was no statistically significant difference in acid-suppressing effect between cimetidine and famotidine during the short-term post-administration period. Conclusion: Rapidity of antisecretory activity did not differ between oral cimetidine and famotidine administered orally.

Immediate acid‐suppressing effects of ranitidine hydrochloride and rabeprazole sodium following initial administration and reintroduction: A randomized, cross‐over study using wireless pH monitoring capsules

“…Both drugs have potent acid‐suppressing effects, but they have different clinical characteristics. H 2 RA have a rapid onset of acid‐suppressing effects and are effective for acid control, particularly at night 1,2 . However, it has been reported that the long‐term administration of H 2 RA causes tolerance and attenuation of its acid‐suppressing effect 3,4 .…”

“…H2RA have a rapid onset of acid-suppressing effects and are effective for acid control, particularly at night. 1,2 However, it has been reported that the long-term administration of H2RA causes tolerance and attenuation of its acid-suppressing effect. 3,4 Also, a rebound phenomenon that causes symptom and ulcer recurrence after the cessation of medication has been reported as another weak point of H2RA.…”

A double-blind, controlled study comparing lafutidine with placebo and famotidine in Japanese patients with mild reflux esophagitis

“…Furthermore, placebo effect could be higher because we set the baseline symptoms of heartburn only once or more in the observation period in our study. H 2 RAs have been reported to inhibit gastric acid secretion more promptly than PPIs and are therefore expected to rapidly improve symptoms of heartburn [18][19][20][21].…”

Intra-gastric pH following single oral administrations of rabeprazole and esomeprazole: double-blind cross-over comparison

“…An intra-gastric pH monitoring sensor catheter (Zenetics Medical, Salt Lake City, UT) was introduced into the gastric body and monitoring was started at 17:00, as previously reported. (16,17) A single oral dose of the PPI was administered at 15 min before supper, at 18:45. The subjects started eating their supper (carbohydrates 112.8 g, protein 16.3 g, fat 27.3 g, calories 762 kcal) at 19:00 and were asked to finish within 30 min.…”