Intra-gastric pH following single oral administrations of rabeprazole and esomeprazole: double-blind cross-over comparison

Furuta, K.; Kohata, Yukie; Fujiwara, Yasuhiro; Sugimoto, Mitsushige; Uotani, Takahiro; Yamade, Mihoko; Sahara, Shu; Ichikawa, Hitomi; Furuta, Takahisa; Nio, Kenta; Iwakiri, Ryuichi; Inamori, Masahiko; Kawamura, Osamu; Kusano, Motoyasu; Kato, Mototsugu; Kawami, Noriyuki; Iwakiri, Katsuhiko; Takeuchi, Toshihisa; Higuchi, Kazuhide; Aimi, Masahito; Naora, Kohji; Fujimoto, Kazuma; Kinoshita, Yoshikazu

doi:10.3164/jcbn.14-41

Cited by 13 publications

(17 citation statements)

References 29 publications

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“…(12,13) When patients had no history of eradication therapy, H. pylori infection was confirmed when any one of these tests was positive. After eradication therapy, cured status was confirmed via a 13 C-urea breath test.…”

Section: Methodsmentioning

confidence: 99%

Characteristics of gastric cancer detected within 1 year after successful eradication of <i>Helicobacter pylori</i>

Nishizawa

Suzuki

Arano

et al. 2016

J. Clin. Biochem. Nutr.

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Gastric cancers are sometimes diagnosed in patients who have successfully undergone Helicobacter pylori (H. pylori) eradication. We analyzed the clinicopathological features of gastric cancers detected after eradication to clarify their characteristics. We reviewed 31 patients with 34 cases of gastric cancer detected after successful H. pylori eradication. Clinicopathological characteristics analyzed included interval since eradication, interval since last endoscopy, tumor size, and depth of invasion. Patients were classified into two groups: early detection (<1 year since eradication) and delayed detection (≥1 year since eradication). The interval since last endoscopy was significantly shorter in the early detection group than in the delayed detection group. However, gastric cancers were significantly larger and more invasive in the early detection group than in the delayed detection group. In conclusion, diligent endoscopy is necessary during the first year after successful H. pylori eradication. (The University Hospital Medical Information Network clinical trial registration number is UMIN000018541.)

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Section: Methodsmentioning

confidence: 99%

Characteristics of gastric cancer detected within 1 year after successful eradication of <i>Helicobacter pylori</i>

Nishizawa

Suzuki

Arano

et al. 2016

J. Clin. Biochem. Nutr.

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“…In consideration of these results, the control of reflux symptoms that impair the quality of life [4] is of utmost importance when treating patients with mild RE. Although on-demand therapy with proton pump inhibitors (PPIs), has been reported as effective for patients with PPI-responsive non-erosive reflux disease and mild RE [1, 5, 6], it is impossible to obtain a gastric pH of 4 or above in a short time after administration of PPI [7, 8], and 3–5 days are necessary for consistent acid suppressive effects [9, 10]. Moreover, as the time of occurrence of reflux symptoms is unpredictable, continued PPI therapy is often indicated.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of On-Demand Therapy Using 20-mg Vonoprazan for Mild Reflux Esophagitis

Umezawa¹,

Kawami²,

Hoshino³

et al. 2018

Digestion

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Background: The study aimed to evaluate the efficacy of on-demand therapy using 20-mg vonoprazan for mild reflux esophagitis (RE). Methods: On-demand therapy by taking one 20-mg tablet of vonoprazan only when reflux symptoms occurred was performed for 24 weeks using 30 patients with mild RE who were receiving maintenance therapy with proton pomp inhibitors (PPIs). The presence or absence of RE, degree of overall satisfaction with the treatment, score of symptoms, and fasting gastrin level before breakfast were examined before and after on-demand therapy. The number of tablets taken during the 24-week period was also noted. Results: One of the 30 patients dropped out of on-demand therapy 1 week after its initiation. Remission was maintained in 25 (86.2%) of the 29 patients (all 10 [100%] Los Angeles classification grade A patients and 15 (78.9%) of the 19 grade B patients). However, 4 grade B patients exhibited grade B relapse. There were no differences in the degree of overall satisfaction, score of symptoms or the gastrin level between PPI and on-demand therapies. The number of vonoprazan tablets taken during the observation period was 33 tablets (median)/24 weeks. Conclusion: On-demand therapy using 20-mg vonoprazan tablets is an effective alternative maintenance therapy for mild RE.

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“…In our previous study, which utilized a single PPI administration, we found that the acid suppressing effect of esomeprazole tended to be stronger than that of rabeprazole with preprandial administration, whereas the acid suppressing effect of rabeprazole tended to be stronger than that of esomeprazole with postprandial administration [14]. In the present study, we compared the acid suppressing effects between pre- and postprandial administrations of esomeprazole and rabeprazole after a 7-day period.…”

Section: Discussionmentioning

confidence: 99%

“…Such postprandial administration may present problems for difficult cases, as all PPIs available in Japan are thought to show a suboptimal acid suppressing effect with that administration protocol. However, few reports have noted a lowered acid suppressing effect with postprandial PPI administration [14,15,16]. In addition, esomeprazole is the only PPI for which plasma concentration and area under the curve (AUC) have been shown to be reduced after postprandial as compared to preprandial administration [15], and there is no known report that compared the acid suppressing effects of pre- and postprandial administrations of rabeprazole.…”

Section: Introductionmentioning

confidence: 99%

Effect of Timing of Proton Pump Inhibitor Administration on Acid Suppression

Furuta

Adachi²,

Aimi³

et al. 2015

Digestion

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Background: Esomeprazole has been reported to show a strong acid suppression following preprandial as compared to postprandial administration, though no known study has compared the acid suppressing effects of other proton pump inhibitors between those administrations. The aim of this study was to compare intragastric pH levels following pre- and postprandial administrations of rabeprazole and esomeprazole. Methods: In 15 Helicobacter pylori-negative healthy volunteers, we measured intragastric pH after 7 days of pre- and postprandial administrations of rabeprazole (10 mg) or esomeprazole (20 mg) using a 5-way crossover design. Results: Preprandial administration of esomeprazole showed stronger acid suppression than postprandial administration. The values for percent time at pH >4.0 over a 24-hour period increased from 45.3% with postprandial administration of esomeprazole to 54.4% with preprandial administration, while the percent time at pH >4.0 during daytime was increased to a greater extent from 51.4 to 66.5% with preprandial administration (p = 0.05). On the other hand, the acid suppressing effect of rabeprazole was not influenced by the timing of administration. Conclusions: The acid suppressing effect of esomeprazole is influenced by administration timing. In contrast, the acid suppressing effect of rabeprazole is not augmented by preprandial administration.

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Intra-gastric pH following single oral administrations of rabeprazole and esomeprazole: double-blind cross-over comparison

Cited by 13 publications

References 29 publications

Characteristics of gastric cancer detected within 1 year after successful eradication of <i>Helicobacter pylori</i>

Characteristics of gastric cancer detected within 1 year after successful eradication of <i>Helicobacter pylori</i>

Efficacy of On-Demand Therapy Using 20-mg Vonoprazan for Mild Reflux Esophagitis

Effect of Timing of Proton Pump Inhibitor Administration on Acid Suppression

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