Immediate acid‐suppressing effects of ranitidine hydrochloride and rabeprazole sodium following initial administration and reintroduction: A randomized, cross‐over study using wireless pH monitoring capsules

Abstract

In view of our observations, we expect symptoms associated with gastric acidity to be more adequately controlled with rabeprazole sodium in the short term when compared to ranitidine hydrochloride.

Lack of incremental effect of histamine receptor antagonists over proton pump inhibitors on the risk of neoplastic progression in patients with Barrett's esophagus: a cohort study

“…The reason for the lack of effect of H 2 RA on BE progression may be the lack of a sustained acid suppression effect with H 2 RA. Tachyphylaxis is a well‐known phenomenon associated with H 2 RA and is observed as early as day 2 . This effect can persist for as long as 3 days after a single dose and further increase in dose does not improve the anti‐secretory effect .…”

Usefulness of catheterless radiotelemetry pH monitoring system to examine the relationship between duodenal acidity and upper gastrointestinal symptoms

“…A future large‐scale study will be needed to determine the usefulness of our method, because the number of the present study subjects was relatively small. However, our method for examining intraluminal pH in the duodenal second portion can be easily and repeatedly carried out, as shown in the report of the intragastric pH measurement by using the Bravo capsule 21–24 . In addition, the inhibitory effect of anti‐secretory therapy on intraduodenal pH could be consecutively measured using our method, because the Bravo system can measure pH continuously for as long as 48 h 22,23 .…”

“…These limitations are largely eliminated by radiotelemetry‐based pH monitoring 19,20 . Recently, intragastric and intraduodenal acidity has been investigated using the Bravo capsule pH monitoring system after endoscopic fixation of the capsule to the gastroduodenal wall using an endoscopic hemoclip 21–25 . Bratten et al .…”

“…The Bravo pH monitoring system (Medtronic; Minneapolis, MN, USA) is a catheterless radiotelemetry pH monitoring system, which has been shown to be useful for recording intraesophageal pH without disturbing the normal daily activities of the study subjects 19,20 . Recently, it was reported that intragastric and intraduodenal acidity could be investigated using this system by endoscopic fixation of a Bravo pH capsule to the mucosa of the stomach and duodenum 21–25 . In the present study, we investigated the usefulness of a newly designed method for measuring intraduodenal pH to examine the relationship between duodenal acidity and upper gastrointestinal symptoms during intragastric acid infusion test.…”

Evidence-based treatment of frequent heartburn: The benefits and limitations of over-the-counter medications

“…OTC H 2 RAs are indicated for treatment of heartburn and prevention of heartburn associated with eating food or drinking beverages that cause heartburn. A single dose of an H 2 RA can be effective for relieving and/or preventing heartburn, but repeat dosing can lead to rapid development of tolerance (tachyphylaxis; Figure ; Bardhan et al., ; Fackler, Ours, Vaezi, & Richter, ; Fandricks, Lönroth, Pettersson, & Vakil, ; Furuta et al., ; Gillen & McColl, ; Hsu et al., ; Huang & Hunt, ; Hurlimann, Abbüh, Inauen, & Halter, ; Komazawa et al., ; Lanzon‐Miller et al., ; Merki et al, ; Merki & Wilder‐Smith, ; Miner, Allgood, & Grender, ; Nwokolo, Smith, Gavey Sawyerr, & Pounder, ; Ono et al., ; Shimatani et al., ; Wilder‐Smith & Merki, ).…”