Comparative study of metallic biomaterials toxicity: a histochemical and immunohistochemical demonstration in mouse spleen

Ferreira, Maria Eduarda; Pereira, Maria de Lourdes; Costa, Fernando Garcia e; Sousa, João Paulo Barreto de; Carvalho, Graça Simões de

doi:10.1016/s0946-672x(03)80045-7

Cited by 42 publications

(25 citation statements)

References 21 publications

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“…64 These effects have not been recreated in experimental animals exposed to metal alloy solutions, although lymphoid populations were significantly altered. 65 The liver. Hepatocellular necrosis often occurs in response to very high levels of metal in the body, as observed after acute ingestion of Cr(VI) in humans.…”

Section: Systemic Toxicologymentioning

confidence: 99%

Orthopaedic metals and their potential toxicity in the arthroplasty patient

Keegan

Learmonth

Case

2007

The Journal of Bone and Joint Surgery. British volume

293

196

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The long-term effects of metal-on-metal arthroplasty are currently under scrutiny because of the potential biological effects of metal wear debris. This review summarises data describing the release, dissemination, uptake, biological activity, and potential toxicity of metal wear debris released from alloys currently used in modern orthopaedics. The introduction of risk assessment for the evaluation of metal alloys and their use in arthroplasty patients is discussed and this should include potential harmful effects on immunity, reproduction, the kidney, developmental toxicity, the nervous system and carcinogenesis.

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Section: Systemic Toxicologymentioning

confidence: 99%

Orthopaedic metals and their potential toxicity in the arthroplasty patient

Keegan

Learmonth

Case

2007

The Journal of Bone and Joint Surgery. British volume

293

196

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“…Implantation of PLA as well as magnesium-containing resorbable materials induced the insignificant non-specific inflammation in surrounding tissues and demonstrated a moderate level of neutrophilic and macrophage infiltration, presence of giant foreign-body cells and small amount of T-lymphocytes with a decrease tendency of these parameters from three to six months of implantation period [4,5]. Unfortunately, just a few of contemporary studies described morphological changes in the regional lymph nodes after the intraosseous implantation of PLA [31] and in spleen after the drainage of different metal ions [32], though it is well known that any inflammatory stimuli involve the lymph nodes, which act as defensive barriers [33]. Thus, any immune response against foreign antigens is often associated with lymph node enlargement (lymphadenopathy) [33].…”

Section: Introductionmentioning

confidence: 99%

Comparison of morphological changes in efferent lymph nodes after implantation of resorbable and non-resorbable implants in rabbits

et al. 2011

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BackgroundMagnesium alloys as biodegradable implant materials received much interest in recent years. It is known that products of implant degradation can induce several types of immune response. Hence, the aim of this study was to examine the morphological changes of efferent lymph nodes after implantation of different resorbable magnesium alloys (MgCa0.8, LAE442) in comparison to commercially available resorbable (PLA) and non-resorbable (titanium) implant materials as well as control groups without implant material.MethodsThe different implant materials were inserted intramedullary into the rabbit tibia. After postoperative observation periods of three and six months, popliteal lymph nodes were examined histologically and immunhistologically and compared to lymph nodes of sham operated animals and animals without surgery. Haematoxylin and eosin staining was performed for cell differentiation. Mouse anti-CD79α and rat anti-CD3 monoclonal primary antibodies were used for B- and T-lymphocyte detection, mouse anti-CD68 primary antibodies for macrophage detection. Evaluation of all sections was performed applying a semi quantitative score.ResultsThe histological evaluation demonstrated low and moderate levels of morphological changes for both magnesium alloys (LAE442 and MgCa0.8). Higher than moderate values were reached for titanium in sinus histiocytosis and histiocytic apoptosis (3 months) and for PLA in histiocytic apoptosis (3 and 6 months). The immune response to all investigated implants had a non-specific character and predominantly was a foreign-body reaction. LAE442 provoked the lowest changes which might be due to a lower degradation rate in comparison to MgCa0.8. Therewith it is a promising candidate for implants with low immunogenic potential.ConclusionBoth examined magnesium alloys did not cause significantly increased morphological changes in efferent lymph nodes in comparison to the widely used implant materials titanium and PLA. LAE442 induced even lower immunological reactions. Therewith MgCa0.8 and especially LAE442 are appropriate candidates for biomedical use.

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“…This consideration arises from the concern that active corrosive processes may lead to the release of metallic products into the vicinity of implants, accumulate in tissues and trigger host response. Potentially, such response can be chronic and lead to various adverse effects on human health [15][16][17]. It has been shown that corrosion processes may be accelerated in samples subjected to loading through the facilitation of crack initiation and propagation [18,19], which deteriorate the mechanical performance of an implant.…”

Section: Resultsmentioning

confidence: 99%

Non‐Conventional Fatigue Testing of CP Titanium for Medical Implants

Medvedev¹,

Lapovok²,

Estrin³

et al. 2016

Proceedings of the 13th World Conference on Titanium

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A major requirement on Ti-based surgical implants is high fatigue strength. In the present work it has been demonstrated that nanostructuring by equal channel angular pressing results in a marked improvement of the fatigue performance of CP Ti, leading to levels of fatigue strength that are on par with that of the Ti-6Al-4V alloy. The fatigue strength under conventional load control tension-compression testing was more than doubled. In addition, an implant is exposed to cyclic loading and its fatigue endurance may be compromised by corrosive bodily fluids. In this work non-conventional fatigue testing (bending-unbending of plate-shaped specimens) in air and in simulated body fluid has been carried out for coarse grained and ultrafine grained CP titanium. The outcomes of the study will be presented vis-à-vis results of conventional tension-compression fatigue testing of CP titanium.

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Comparative study of metallic biomaterials toxicity: a histochemical and immunohistochemical demonstration in mouse spleen

Cited by 42 publications

References 21 publications

Orthopaedic metals and their potential toxicity in the arthroplasty patient

Orthopaedic metals and their potential toxicity in the arthroplasty patient

Comparison of morphological changes in efferent lymph nodes after implantation of resorbable and non-resorbable implants in rabbits

Non‐Conventional Fatigue Testing of CP Titanium for Medical Implants

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