Comparative osteoradionecrosis rates in bony reconstructions for head and neck malignancy

Head and neck radiotherapy-induced changes in dentomaxillofacial structures detected on panoramic radiographs: A systematic review

“…A total of 13,261 research articles were initially found in the databases after searching for all keywords. After applying the eligibility criteria and removing overlapping studies, 13,228 investigations were excluded, and a total of 33 studies 5 , 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 on the oral and maxillofacial effects of radiotherapy, as assessed by panoramic radiographs, were included. Table 1 summarizes the details of the selected studies.…”

“… 38 39 Some studies were exclusively dedicated to patients with oral squamous cell carcinomas, 21 25 32 rhabdomyosarcoma survivors, 10 14 22 patients with osteoradionecrosis, 17 36 40 and patients in whom the outcomes of surgical procedures such as mandibulotomy 11 19 34 or the use of mandible reconstruction methods were investigated. 13 15 26 27 …”

“… 17 31 The effects on oral structures such as teeth in children survivors of head and neck rhabdomyosarcoma was the subject of 4 investigations. 10 14 22 33 Surgical outcomes or complications in patients who received radiotherapy were evaluated in 10 studies, 9 11 13 15 19 25 26 27 34 37 while changes in marginal bone levels or survival rates of implants were investigated in 2 studies. 21 24 Lastly, the appearance of the mandible, 20 29 apical periodontitis, 5 and dental abnormalities or dental status alterations due to radiotherapy 18 23 28 30 32 33 were also assessed using panoramic radiographs.…”

“…Four studies included patients with benign lesions in their samples; 15 24 26 27 in these studies, evaluating the effects of radiotherapy was a secondary objective, and the studies focused on post-surgical calcification of the pedicle in cases of mandibulotomy 26 and a broad range of surgical outcomes, 13 27 as well as on implant placement or survival. 15 24 …”

“… 12 18 23 27 33 40 Regarding studies where the type of radiotherapy was missing, we assumed that conventional radiotherapy had been used. 10 12 13 16 18 19 23 24 25 26 27 28 29 33 35 37 38 39 40 Nevertheless, the radiation dose was essential information that could not be deduced. The assessment results of the risk of bias are presented in Table 3 .…”