Comparative “in vitro” evaluation of the antiresorptive activity residing in four Ayurvedic medicinal plants. Hemidesmus indicus emerges for its potential in the treatment of bone loss diseases

Pompo, Gemma Di; Poli, Ferruccio; Mandrone, Manuela; Lorenzi, Beatrice; Roncuzzi, Laura; Baldini, Nicola; Granchi, Donatella

doi:10.1016/j.jep.2014.04.033

Cited by 21 publications

(15 citation statements)

References 42 publications

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“…Phenolic compounds like flavonoids, steroids, and tannins are the major source of antioxidants, which are highly present in medicinal plants. [ 23 ] Plant phenols are widely distributed in the tissue of plants as well as exposed a vital role in the free radical scavenging activity. Antioxidant activity of the phenols is mainly due to their redox, hydrogen donor and singlet oxygen quenching ability.…”

Section: Discussionmentioning

confidence: 99%

Assessment of antioxidant potential and acute toxicity studies of whole plant extract of pergularia daemia (Forsk)

Vaithiyanathan

Mirunalini

2015

Toxicol Int

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Background:Pergularia daemia (Asclepiadacea) is a fetid- smelling perennial herb growing well along the river bang and road sides of India. Naturally the plant has powerful antioxidants including polyphenols, flavanoids, steroids and terpenoids.Objective:The aim of this study is to evaluate the in vitro antioxidant potential and to determine the median lethal dose (LD50) of crude ethyl acetate and methanol extracts of Pergularia daemia. The plant Pergularia daemia possess effective scavenging activity against 2, 2' azino bis (3 ethylbenzothiazoline 6 sulfonic acid (ABTS), nitric oxide and reducing power radicals at different concentrations (100, 200, 300, 400 & 500 µg/mL) of both extracts.Results:From the above in vitro assay we have exposed that the methanolic extract exert higher antioxidant activity at 400 µg/mL than ethyl acetate extract. Acute toxicity study revealed that the extracts showed no signs of toxicity upto a dose level of 2500 mg/kg b.wt.Conclusion:Thus our findings provide that both extracts of Pergularia daemia possess a strong antioxidant capacity and are relatively has high margin of safety.

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Section: Discussionmentioning

confidence: 99%

Assessment of antioxidant potential and acute toxicity studies of whole plant extract of pergularia daemia (Forsk)

Vaithiyanathan

Mirunalini

2015

Toxicol Int

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“…Samanga [45] -In vitro study was done on four medicinal plants for evaluation of antiresorptive activity in the treatment of bone loss disease. All the four drug decoction inhibited osteoclastogenesis similarly to standard alendronate at the highest doses, but Hemidesmus indicus was found effective at lower concentrations also.…”

Section: Managementmentioning

confidence: 99%

Ayurveda medicinal plants for Asthikshaya (Osteoporosis): A review

Dipti¹,

Khandelwal²,

Aggarwal³

et al. 2016

J. Ayu. Her. Med.

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Ayurveda is an ancient science of life deals with the preventive as well as curative aspect. It explains human body as a ‘congenial homeostasis’ of doṣa, dhatuand mala. The function of dhatu is dharaṇa (maintain the structure) of the sharira (body). Among the dhatu, asthidhatu is responsible for maintenance of structural frame work of the body. It gives shape to the body and protects the vital organs. Concept of osteoporosis has explained under 18 types of kṣhaya by Acharya Carakain sutra sthan kiyantahshirasiya adhyaya. Asthikṣhaya pathogenesis can be explained in many ways in Ayurveda. According to the principles of ashrayaashrayibhava, asthidhatu is the seat of vata doṣa and inversely related to each other. Increase of vata is the main factor responsible for asthikṣhaya. Acharya Caraka has opined increase of vata may follow two patterns; one is from margavaraṇa and another is from dhatukṣhaya which can further lead to asthikṣhaya. Osteoporosis or porous bone is a global problem characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility and an increased risk of fractures of the hip, spine and wrist. Men as well as women are affected by osteoporosis but females are at higher risk. This risk even increases at the time of menopause, which is the period of hormonal imbalance. Treatment available in modern science is mainly symptomatic and not devoid of adverse effects. Ayurveda treatment visualizes the human body as a single unit and this approach has opened many innovative approaches for treatment. On this background present study was taken to analyze the fundamental concept of asthikshaya and to find out single herbs beneficial for it. Drugs from classical texts along with commonly used in practice have been analyzed in context of asthikshaya. Study reveals that drugs like guduchi, ashwagandha, prishnaparni, samanga, vacha etc. possess kaphavatashamak properties which helps in breaking the pathogenesis by clearing and nourishing the srotas (channels). Drugs like madhuyasti, priyangu, vidarikanda, shatavari etc. have vatapittashamak, balya (tonic), brimhan (nourishing) properties works directly on dhatukshaya.

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“…9 Ayurveda recommends many plant based preparations for management of several diseases. 10 In fact there is a growing acceptance of traditional medicines all over the world, for being a rich bio resource of therapeutic leads for pharmaceutical companies. However, without proper standardization and validation on effectiveness and the possible risks, these traditional medicines cannot be used.…”

Section: It Ismentioning

confidence: 99%

Effects of a standardized Ayurvedic formulation on diabetes control in newly diagnosed Type-2 diabetics; a randomized active controlled clinical study

Awasthi¹,

Nath²,

Usman³

et al. 2015

Complementary Therapies in Medicine

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Comparative “in vitro” evaluation of the antiresorptive activity residing in four Ayurvedic medicinal plants. Hemidesmus indicus emerges for its potential in the treatment of bone loss diseases

Cited by 21 publications

References 42 publications

Assessment of antioxidant potential and acute toxicity studies of whole plant extract of pergularia daemia (Forsk)

Assessment of antioxidant potential and acute toxicity studies of whole plant extract of pergularia daemia (Forsk)

Ayurveda medicinal plants for Asthikshaya (Osteoporosis): A review

Effects of a standardized Ayurvedic formulation on diabetes control in newly diagnosed Type-2 diabetics; a randomized active controlled clinical study

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